Nutritional Supplementation for Bruising

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: Standard Process Inc.

Must not be taking: Aluminum, Iron, PPIs, Retinol

Disqualifiers: Allergies, Liver disease, Cancer, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 3

Duration: 8 weeks

30 Participants Needed

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial aims to test a nutritional supplement called Cyruta Plus and compare its effects to low and high doses of Vitamin C in reducing bruising from actinic purpura, a condition where blood spots appear on the skin, common in older adults. Researchers seek to determine if these supplements can improve skin condition over an 8-week period. Individuals with actinic purpura who are not using certain topical or oral products may be suitable candidates for this trial. As an unphased trial, this study provides participants the opportunity to contribute to understanding potential new treatments for skin conditions.

Will I have to stop taking my current medications?

The trial does not specify if you need to stop taking your current medications, but you must not use products containing aluminum, iron, proton pump inhibitors, or topical retinol. If you are on other medications, you need to have been on a stable dose for the last 3 months before starting the trial.

Is there any evidence suggesting that this trial's treatments are likely to be safe?

Research has shown that Cyruta Plus is generally safe. This supplement is often used to improve blood vessel health and circulation. Although specific safety data for humans is limited, it is typically used without major issues.

Studies have found vitamin C to be mostly safe when taken in recommended amounts. The low-dose vitamin C in this trial is unlikely to cause problems. Even high doses are safe for most people, though very high amounts can sometimes lead to stomach upset or kidney stones. However, the doses in this trial are much lower than those levels.

Overall, both treatments have a good safety record in general use. Participants should still consult their doctor if they have any concerns. ^{1 2 3 4 5}

Why are researchers excited about this trial's treatments?

Unlike the standard of care for bruising, which typically involves topical treatments and lifestyle changes, Cyruta Plus offers a unique nutritional approach. Cyruta Plus is derived from a specific combination of plant-based compounds that aim to improve capillary integrity and reduce bruising from within. Researchers are excited about this treatment because it represents a shift from external applications to a systemic solution, potentially offering a more comprehensive way to manage and prevent bruising. Additionally, its plant-based composition may provide a natural alternative for those seeking non-pharmaceutical options.

What evidence suggests that this trial's treatments could be effective for actinic purpura?

This trial will compare the effects of Cyruta Plus with both high-dose and low-dose Vitamin C on bruising. Studies have shown that Cyruta Plus, a natural supplement, may address issues like easy bruising and weak blood vessels. It is believed to improve blood flow and support healthy blood vessels, potentially benefiting skin conditions such as actinic purpura. Some users have reported improved skin health soon after starting it.

Participants in another arm of this trial may receive high doses of Vitamin C, which are known to aid healing and reduce bruising, particularly in those with insufficient dietary Vitamin C. Research has shown that Vitamin C can help with conditions like pressure sores, which resemble bruises. This suggests it might also assist with actinic purpura by promoting skin repair and reducing the size of skin lesions. ^{1 2 3 6 7}

Are You a Good Fit for This Trial?

This trial is for healthy adults aged 55 and older who experience actinic purpura, commonly known as skin bruising due to aging. Participants should be seeing bruises on their skin but otherwise feel well.

Inclusion Criteria

Not concomitantly participating in a study involving nutritional products

I am 55 years old or older.

I have or had skin bruises due to sun damage.

Exclusion Criteria

Having a known allergy or intolerance to nuts, seeds, fruits, vegetables, oils, and fish

Not complying with the study protocol

Having a known allergy, intolerance, or dietary restriction to any of the study ingredients (Vitamin C, organic buckwheat (aerial parts) juice powder, organic buckwheat flour, bovine adrenal Cytosol™ extract, oat flour, honey, ascorbic acid, and calcium stearate)

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive an 8-week nutritional supplement intervention or vitamin C supplements

8 weeks

3 visits (in-person): baseline, 4-week, and 8-week

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

• Cyruta Plus
• High Dose Vitamin C
• Low Dose Vitamin C

Trial Overview The study tests if a nutritional supplement called Cyruta Plus can improve skin health compared to regular vitamin C. Over 8 weeks, changes in the participants' skin will be monitored through questionnaires, photos, and clinical evaluations.

How Is the Trial Designed?

Group I: Cyruta Plus Experimental Treatment 1 Intervention

Total of 27 mg daily

Group II: Low-dose Vitamin C Active Control 1 Intervention

Total of 27 mg daily

Group III: High-dose Vitamin C Active Control 1 Intervention

Total of 500 mg daily

Who Is Running the Clinical Trial?

Standard Process Inc.

Lead Sponsor

Trials

15

Recruited

680+

Published Research Related to This Trial

In a review of 13 randomized controlled trials involving 650 patients with head and neck cancer, antioxidants like vitamin E and zinc significantly reduced the severity of oral mucositis compared to placebo, with vitamin E reducing the risk of severe mucositis by 60% and zinc by 95%.

Despite these promising results, the overall quality of evidence is low due to the limited number of studies and potential biases, indicating a need for larger, more rigorous trials to confirm the effectiveness of these antioxidants.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Efficacy of oral and topical antioxidants in the prevention and management of oral mucositis in head and neck cancer patients: a systematic review and meta-analyses. Raza, A., Karimyan, N., Watters, A., et al.[2022]

Citations

1. clinicaltrials.gov clinicaltrials.gov/study/NCT06840574

The Effect of Nutritional Supplementation on Actinic ... Dietary Supplement : Cyruta Plus: A Whole-Food Based Vitamin C supplement containing organic buckwheat (aerial parts) juice powder, organic buckwheat flour, ...

2. withpower.com withpower.com/trial/phase-purpura-2-2025-79c55

Nutritional Supplementation for Bruising Trial Overview The study tests if a nutritional supplement called Cyruta Plus can improve skin health compared to regular vitamin C. Over 8 weeks, changes in ...

3. standardprocess.com standardprocess.com/products/cyruta-plus

Cyruta® Plus Supports circulatory cholesterol transport* · Supports healthy cellular glucose handling to help maintain blood sugar levels already within normal range* ...

4. nhc.com nhc.com/cyruta-plus-by-standard-process?srsltid=AfmBOor3wltitVprPEQlPgRiFrKEAjg6jvL4aSHvKdgLkEjl2pg8FQl2

Standard Process Cyruta Plus The overall improvement was rapid - within days I could feel a difference. I might be over-reacting here, but I can only imagine how close I might have been to ...

5. welladjustedinc.com welladjustedinc.com/about-us/what-we-do/standard-process-nutrition.html

Standard Process Nutrition It helps with bleeding gums or people who bruise easily. Cyruta® Plus: This product is good for bleeding gums, bruising, capillary weakness, gingivitis, ...

6. amazon.com amazon.com/Standard-Process-Supports-Peripheral-Circulation/dp/B012YIAOGU

Standard Process Cyruta Plus - Capillary & Circulation ... Capillary Care Support: Cyruta Plus is a nutritional supplement that supports circulatory cholesterol transport and aids healthy peripheral circulation* ...

7. perfectlyhealthy.com perfectlyhealthy.com/products/standardprocess-cyruta-plus-3325?srsltid=AfmBOopizsNZVvOVar3zTKiMuDkPvH4GO0SxjBjJHjdYPv-J31qISOvn

Cyruta® Plus, 90 Tablets Cyruta® Plus supports capillary integrity and function.* Supports circulatory cholesterol transport* Supports healthy cellular glucose handling to help ...