IgY Supplement for Immune System Support

Overseen By Isaac Wong, MBT

Age: 18+

Sex: Any

Trial Phase: Phase 1

Sponsor: Nimble Science Ltd.

Must not be taking: Antidepressants, Antipsychotics, Antihypertensives, others

Disqualifiers: Gastrointestinal disease, Cancer, Immunological disease, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: Unknown

Duration: 6 weeks

20 Participants Needed

Trial Summary

Will I have to stop taking my current medications?

Yes, if you are using regular prescription medications like antihypertensives or antidepressants, you may not be eligible for the trial. Also, if you are taking proton pump inhibitors, you need a 48-hour break before taking the study capsules.

What data supports the effectiveness of the IgY supplement treatment for immune system support?

Research on similar treatments, like immunonutrition, shows that adding certain nutrients to diets can help reduce infections, especially in patients undergoing surgery for gastrointestinal cancer. Although the studies have some flaws, they suggest that enhancing immunity through diet can be beneficial. ^{1 2 3 4 5}

Is the IgY supplement generally safe for humans?

Research suggests that IgY, derived from egg yolk, is considered safe for use in humans. It is cost-effective, minimizes animal harm, and has reduced reactivity with human factors, making it a promising option for health products. ^{6 7 8 9 10}

How is the IgY supplement treatment different from other treatments for immune system support?

The IgY supplement is unique because it uses antibodies extracted from egg yolks, which are cost-effective and ethically produced without harming animals. Unlike traditional antibiotics, IgY can be used continuously without causing resistance and supports the body's natural microbiome, making it a natural and non-toxic option for immune system support. ^{7 9 11 12 13}

What is the purpose of this trial?

This study is to evaluate whether Muno-IgY is effective in enhancing immune health among adults over a six week period.

Eligibility Criteria

Adults aged 18-65 who can swallow a capsule and are willing to keep their diet and exercise the same during the study. They must not be on medications that affect the trial, planning pregnancy, have egg allergies or certain diets, substance abuse issues, serious health conditions, recent cancer treatments, antibiotic use, pregnant or breastfeeding.

Inclusion Criteria

Signed Informed Consent; willing and able to comply with study procedures

I can swallow a large capsule.

Willing to maintain their diet and physical activity levels during the study

Exclusion Criteria

I am not on any medications that could harm me during the study.

Planning to become pregnant

Scheduled for an MRI at any time during the study

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive the Muno-IgY supplement daily and are monitored for safety and effectiveness

6 weeks

Daily ingestion, regular monitoring

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

Treatment Details

Interventions

• IgY supplement

Trial Overview The trial is testing Muno-IgY supplement's effectiveness in boosting immune health over six weeks. Participants will take this supplement to see if it has positive effects on their gut microbiome and overall immunity.

Participant Groups

Group I: IgY Supplement Experimental Treatment 1 Intervention

Participants will ingest the IgY supplement on a daily basis

Who Is Running the Clinical Trial?

Nimble Science Ltd.

Lead Sponsor

Trials

11

Recruited

570+

IGY Immune Technologies & Life Sciences Inc.

Collaborator

Trials

1

Recruited

20+

Findings from Research

Immunonutrition, which includes nutrients like glutamine, omega-3 fatty acids, and arginine, has been studied for its potential to influence immune responses, but individual supplements generally showed no significant clinical efficacy in randomized controlled trials.

Commercial immunonutrition formulas have demonstrated better outcomes compared to standard nutrition support in some trials, but design flaws in these studies make it unclear whether the benefits are due to the immunonutrients themselves or the overall nutrition regimen.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Immunonutrition: can you be what you eat? Koretz, RL.[2019]

Many dietary supplements claiming to boost the immune system have misleading labels that do not meet FDA standards, raising concerns about their reliability.

Quality control for these supplements is generally inadequate, which could affect their safety and effectiveness for consumers.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Dietary Supplement Labels May Be Inaccurate and Misleading. Rosenberg, K.[2022]

References

1. Russia (Federation) pubmed.ncbi.nlm.nih.gov

[Immuno-nutrition in intensive care and emergency surgery]. [2015]

2. United States pubmed.ncbi.nlm.nih.gov

Immunodeficiency associated with lymphosarcoma in a horse. [2007]

3. United States pubmed.ncbi.nlm.nih.gov

The immunologic role of the gastrointestinal tract. [2004]

4. United States pubmed.ncbi.nlm.nih.gov

Immunonutrition: can you be what you eat? [2019]

5. United States pubmed.ncbi.nlm.nih.gov

Immunonutrition: problematic or problem solving? [2022]

6. United States pubmed.ncbi.nlm.nih.gov

Use of egg yolk-derived immunoglobulin as an alternative to antibiotic treatment for control of Helicobacter pylori infection. [2019]

7. Netherlands pubmed.ncbi.nlm.nih.gov

IgY-technology (egg yolk antibodies) in human medicine: A review of patents and clinical trials. [2021]

8. Germany pubmed.ncbi.nlm.nih.gov

Effectivity of Alternative Adjuvants in Comparison to Freund's Complete Adjuvant. [2019]

9. Korea (South) pubmed.ncbi.nlm.nih.gov

Effect of microencapsulation of egg yolk immunoglobulin Y by sodium alginate/chitosan/sodium alginate on the growth performance, serum parameters, and intestinal health of broiler chickens. [2023]

10. United States pubmed.ncbi.nlm.nih.gov

Dietary Supplement Labels May Be Inaccurate and Misleading. [2022]

11. England pubmed.ncbi.nlm.nih.gov

Use of chicken immunoglobulin Y in general virology. [2018]

12. China pubmed.ncbi.nlm.nih.gov

[Chicken egg yolk immunoglobulin and its application in medicine]. [2015]

13. Switzerland pubmed.ncbi.nlm.nih.gov

IgYs: on her majesty's secret service. [2023]