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Sildenafil administration for Patent Foramen Ovale

Phase < 1
Waitlist Available
Led By Andrew Lovering, PhD
Research Sponsored by University of Oregon
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 1 hour post intervention
Awards & highlights

Study Summary

This trial will study Croatian breath-hold and SCUBA divers to see if there is a relationship between PFO and IPAVA blood flow and to test if a placebo-controlled intervention (sildenafil) can reduce pulmonary arterial pressure.

Eligible Conditions
  • Patent Foramen Ovale
  • Intrapulmonary Arteriovenous Anastomosis

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~1 hour post intervention
This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 hour post intervention for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in Q-IPAVA
Concentration Of CRP
Concentration Of MMP-2
+11 more

Trial Design

2Treatment groups
Active Control
Placebo Group
Group I: Sildenafil administrationActive Control1 Intervention
Administration of 50mg sildenafil one time, one hour prior to measurements
Group II: Placebo administrationPlacebo Group1 Intervention
Administration of 50mg placebo one time, one hour prior to measurements

Find a Location

Who is running the clinical trial?

University of OregonLead Sponsor
80 Previous Clinical Trials
46,677 Total Patients Enrolled
Andrew Lovering, PhDPrincipal InvestigatorUniversity of Oregon
1 Previous Clinical Trials
10 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Is Blood Flow Through IPAVA and PFO Related to Breath-hold and SCUBA Diving-induced Pulmonary Hypertension?
2019. "Is Blood Flow Through IPAVA and PFO Related to Breath-hold and SCUBA Diving-induced Pulmonary Hypertension?". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03945643.
~14 spots leftby Apr 2025
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