Depression Prevention Programs for Adolescents
(P2P Trial)

Recruiting in Palo Alto (17 mi)

Overseen byTracy RG Gladstone, PhD

Age: < 65

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: University of Illinois at Chicago

No Placebo Group

Trial Summary

What is the purpose of this trial?PATH (Promoting AdolescenT Health) 2 Purpose is a two-arm comparative effectiveness research trial to that will evaluate the ability of the interventions, Competent Adulthood Transition with Cognitive-behavioral \& Interpersonal Training (CATCH-IT) and Teens Achieving Mastery over Stress (TEAMS), to intervene early to prevent depressive illness and potentially other common mental health disorders. Using cluster randomization, 564 participants eligible for the study will be offered one of two different depression prevention programs in multiple sites in Chicagoland, Rockford, Illinois; Dixon, Illinois; and Louisville, Kentucky. In response to the Coronavirus Disease 2019 (COVID-19) pandemic, we will employ a public health media campaign to recruit a second cohort of 100 adolescents state-wide in Illinois, Kentucky, and Massachusetts individually randomized to either intervention. The study will also assess teens', parents' and providers' experiences with each intervention approach. Finally, we will examine the impact of the COVID-19 pandemic on adolescents at-risk for depression who are enrolled in our study.

Eligibility Criteria

This trial is for teens aged 13-19 with a history of depression but not currently depressed, showing elevated depressive symptoms without severe drug/alcohol abuse or high-risk psychiatric conditions. They shouldn't be on recent medication for mood disorders or engaged in cognitive therapy.

Inclusion Criteria

I am between 13 and 19 years old.

Adolescent must be experiencing an elevated level of depressive symptoms (Patient Health Questionnaire-9 Score = 5-18)

I am a teenager who has had depression in the past but not now.

Exclusion Criteria

Did not complete phone assessment with MINI Kid

I am not interested in participating in the trial anymore.

I am not comfortable being audio recorded during group sessions.

+15 more

Participant Groups

The PATH 2 Purpose study compares two programs: CATCH-IT and TEAMS, aimed at preventing depression among adolescents. Participants are randomly assigned to one of the interventions across various locations, assessing their effectiveness and experiences during COVID-19.

2Treatment groups

Experimental Treatment

Active Control

Group I: CATCH-ITExperimental Treatment1 Intervention

Competent Adulthood Transition with Cognitive-behavioral \& Interpersonal Training (CATCH-IT) is an internet-based depression prevention program that targets decreasing modifiable risk factors while enhancing protective factors in at-risk adolescents, and that includes a parent program. It has been shown to be safe, feasible, and efficacious.

Group II: TEAMSActive Control1 Intervention

Teens Achieving Mastery over Stress (TEAMS) is an 8-session group depression prevention program teaching teens how to deal with stress and negative moods, and ways to manage low mood based on cognitive-behavioral therapy (CBT) principles and strategies. Efficacy has been demonstrated by several trials over time.