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Brain Stimulation for Episodic Memory Improvement (BNI Trial)

N/A

Recruiting

Led By Rodrigo M Braga, PhD

Research Sponsored by Northwestern University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Participants will be inpatients of the Northwestern Memorial Hospital Comprehensive Epilepsy Center undergoing intracranial electroencephalography for presurgical planning as part of their routine care for epilepsy

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up immediate during procedure

Awards & highlights

BNI Trial Summary

This trial will use MRI to map brain networks involved in episodic memory, to guide the placement of electrodes for brain stimulation during a memory task.

Who is the study for?

This trial is for adult epilepsy patients at Northwestern Memorial Hospital who are undergoing routine presurgical planning with intracranial EEG, which includes electrode placement in specific brain regions. It's not for minors, pregnant women, prisoners, those unable to consent, or anyone with MRI contraindications like metal implants.Check my eligibility

What is being tested?

The study tests if using individual brain network maps from advanced imaging can guide precise brain stimulation during memory tasks. This could improve understanding of episodic memory and refine brain stimulation therapies for mental health disorders.See study design

What are the potential side effects?

While the description doesn't list specific side effects, general risks may include discomfort at the electrode sites, potential headaches or dizziness post-stimulation, and typical MRI-related issues such as claustrophobia.

BNI Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I am an inpatient at Northwestern Memorial Hospital for epilepsy surgery planning.

BNI Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ immediate during procedure

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~immediate during procedure

This trial's timeline: 3 weeks for screening, Varies for treatment, and immediate during procedure for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Accuracy

Reaction Time

BNI Trial Design

1Treatment groups

Experimental Treatment

Group I: Intervention and Control groupExperimental Treatment1 Intervention

Each patient will receive electrical and sham stimulation, meaning that each patient will act as their own control.

0 / 1Eligibility criteria met

Find a Location

Who is running the clinical trial?

Northwestern UniversityLead Sponsor

1,585 Previous Clinical Trials

916,943 Total Patients Enrolled

Rodrigo M Braga, PhDPrincipal InvestigatorNorthwestern University

Media Library

Brain stimulation (Other) Clinical Trial Eligibility Overview. Trial Name: NCT04748146 — N/A

Episodic Memory Research Study Groups: Intervention and Control group

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does this medical study have recruitment opportunities available?

"Affirmative. ClinicalTrials.gov hosts data that verifies this clinical trial is actively searching for participants, with an initial posting date of February 1st 2023 and the latest update being June 30th 2022. This study requires 20 individuals to be enrolled from a single location."

Answered by AI

How many total individuals are participating in this experiment?

"Affirmative. Information on clinicaltrials.gov demonstrates that this medical trial, initially announced on February 1st 2023, is actively recruiting patients. Approximately 20 individuals are desired to be sourced from a single site."

Answered by AI

Recent research and studies

NeurologyJournal

Direct Cortical Stimulation of Human Posteromedial Cortex

Foster, Brett L., and Josef Parvizi. 2017. “Direct Cortical Stimulation of Human Posteromedial Cortex”. Neurology. Ovid Technologies (Wolters Kluwer Health). doi:10.1212/wnl.0000000000003607.

NeuropsychopharmacologyJournal

The Episodic Memory System: Neurocircuitry and Disorders

Dickerson, Bradford C, and Howard Eichenbaum. 2009. “The Episodic Memory System: Neurocircuitry and Disorders”. Neuropsychopharmacology. Springer Science and Business Media LLC. doi:10.1038/npp.2009.126.

New England Journal of MedicineJournal

Memory Enhancement and Deep-brain Stimulation of the Entorhinal Area

Suthana, Nanthia, Zulfi Haneef, John Stern, Roy Mukamel, Eric Behnke, Barbara Knowlton, and Itzhak Fried. 2012. “Memory Enhancement and Deep-brain Stimulation of the Entorhinal Area”. New England Journal of Medicine. Massachusetts Medical Society. doi:10.1056/nejmoa1107212.

Journal of NeurophysiologyJournal