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Proton Beam Therapy
Proton Beam radiation for Germ Cell Tumors
N/A
Waitlist Available
Led By Shannon MacDonald, MD
Research Sponsored by Massachusetts General Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Histologically confirmed germ cell tumor or elevated AFP or B-HCG in the setting of radiographic disease consistent with a germ cell tumor. Disease must be confined to the central nervous system.
Participants do not need to have measurable disease. Most patients will not have measurable disease at the time of treatment.
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 3 years
Awards & highlights
Study Summary
This study is evaluating whether proton beam radiation therapy will kill the germ cell tumor in the participant's central nervous system.
Eligible Conditions
- Germ Cell Tumors
- Central Nervous System Tumor
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 3 years
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~3 years
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
To describe late complications of craniospinal, whole ventricle, and involved field radiation therapy delivered with proton radiotherapy in place of photon radiation for this patient population.
To evaluate acute and subacute toxicities of craniospinal, whole ventricle, and involved field radiation therapy delivered with proton radiotherapy in place of photon radiation in this patient population.
Secondary outcome measures
To determine 3 year progression free survival rate of patients with pure germ cell tumors and non-germinomatous germ cell tumors treated with proton radiation.
Trial Design
1Treatment groups
Experimental Treatment
Group I: Proton beam radiationExperimental Treatment1 Intervention
Radiation therapy with proton beam
Find a Location
Who is running the clinical trial?
Massachusetts General HospitalLead Sponsor
2,923 Previous Clinical Trials
13,193,348 Total Patients Enrolled
Dana-Farber Cancer InstituteOTHER
1,076 Previous Clinical Trials
340,288 Total Patients Enrolled
1 Trials studying Germ Cell Tumors
500 Patients Enrolled for Germ Cell Tumors
National Institutes of Health (NIH)NIH
2,682 Previous Clinical Trials
6,930,753 Total Patients Enrolled
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