8 Participants Needed

Haskap for Digestion

(PHMTiming Trial)

MS
Overseen ByMeghan Spears, MSc
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

Trial Summary

What is the purpose of this trial?

Diet is a key factor in managing health and individuals at risk of developing metabolic syndrome or other chronic diseases have the opportunity to use diet as a tool to improve their health. This can be complicated when considering the numerous variables that impact digestion and absorption of key health-promoting compounds in foods. One of these variables is the gut microbiome, a microbial community in the digestive tract that interacts with the foods we consume. The mechanisms the microbiome uses to interact with bioactive compounds in foods, like polyphenols, can modulate the health-promoting benefits of polyphenols. Polyphenols are secondary plant metabolites, commonly found in fruit, legumes, chocolate, coffee, and nuts among other foods that have been shown to improve cardiovascular and metabolic health, as well as reduce inflammation and oxidative stress.

Will I have to stop taking my current medications?

If you take medication to lower cholesterol, inflammation, or lipids, you will need to stop taking them to participate in this trial.

Research Team

MP

Mary P Miles, PhD

Principal Investigator

Montana State University

Eligibility Criteria

This trial is for individuals at risk of metabolic syndrome or other chronic diseases, who are interested in using diet to improve their health. It focuses on how the gut microbiome interacts with polyphenols from foods like fruit and nuts.

Inclusion Criteria

Body mass index (BMI) between 18-30 kg/m^2
I am between 18 and 45 years old.

Exclusion Criteria

I have taken antibiotics within the last 3 months.
I take medication for cholesterol, inflammation, or lipids.
Smoke cigarettes
See 6 more

Timeline

Screening

Participants are screened for eligibility to participate in the trial

1-2 weeks

Treatment

Participants consume Haskap puree after a fasting blood sample is collected

48 hours
1 visit (in-person)

Follow-up

Participants are monitored for metabolite identity and abundance after Haskap consumption

1 week

Treatment Details

Interventions

  • Haskap
Trial OverviewThe study tests the effects of Haskap, a berry rich in polyphenols, on microbial colonization and metabolism. The goal is to understand how timing affects the absorption and benefits of these compounds.
Participant Groups
1Treatment groups
Experimental Treatment
Group I: HaskapExperimental Treatment1 Intervention
Haskap puree will be consumed by all participants after a fasting blood sample is collected

Find a Clinic Near You

Who Is Running the Clinical Trial?

Montana State University

Lead Sponsor

Trials
47
Recruited
1,044,000+