Vitamin C for Metabolic Changes
What You Need to Know Before You Apply
What is the purpose of this trial?
The goals of this clinical trial are to determine whether or not vitamin C is able to: (1) increase the body heat generated by the sympathetic nervous system; and, (2) increase circulating vitamin D concentration during sympathetic nervous system stimulation in adult humans aged 18-40 years who meet the criteria for overweight based on body mass index. The main question it aims to answer are:
1. By how much does body temperature increase during stimulation of beta-adrenergic receptors when vitamin C is given.
2. By how much does circulating vitamin D concentration increase during stimulation of beta-adrenergic receptors when vitamin C is given.
Participants will will be asked to:
* undergo measures of body temperature
* have blood sampled on two separate occasions: once during stimulation of beta adrenergic receptors, and once during stimulation of beta-adrenergic receptors while also been given vitamin C.
Who Is on the Research Team?
Christopher Bell, PhD
Principal Investigator
Colorado State University
Are You a Good Fit for This Trial?
This trial is for adults aged 18-40 who are slightly overweight, with a BMI of 25-30 kg/m2 and stable weight. Participants must avoid caffeine and alcohol before study visits and speak English well due to the need for clear communication during invasive procedures.Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo two lab visits where beta-adrenergic receptors are stimulated with isoproterenol, once with saline and once with vitamin C
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Vitamin C
Trial Overview
The trial tests if vitamin C can increase body heat generated by the nervous system and raise vitamin D levels when the sympathetic nervous system is stimulated. It involves measuring body temperature and taking blood samples under two conditions: with stimulation alone, and with both stimulation and vitamin C.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Active Control
Isoproterenol will be infused with vitamin C
Isoproterenol will be infused with saline only
Find a Clinic Near You
Who Is Running the Clinical Trial?
Colorado State University
Lead Sponsor
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