Geranylgeraniol for Sexual Wellness
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests whether a supplement called Geranylgeraniol, derived from Annatto, can improve sexual health in men and women. Participants will take either the supplement or a placebo (a non-active substance) for eight weeks, with a gradual dose increase halfway through. It targets individuals aged 30 to 49 experiencing symptoms affecting sexual health. As an unphased trial, it provides a unique opportunity to contribute to research that could enhance sexual health solutions.
Will I have to stop taking my current medications?
Yes, you will need to stop taking certain medications. The trial excludes those using drugs that are anti-diabetic, anti-platelet, anti-coagulant, beta blockers, or used to treat erectile dysfunction (ED).
Is there any evidence suggesting that Geranylgeraniol supplementation is likely to be safe?
Research has shown that Geranylgeraniol (GG) is generally safe for people. One study found that GG did not cause significant changes in blood tests or hormone levels in men and women, indicating no major changes in important blood markers—a positive sign for safety.
Although detailed safety studies are not widely available, GG is often used as a supplement for healthy aging and energy, suggesting it is well-tolerated.
Overall, GG from Annatto appears safe, with no major safety concerns reported.12345Why are researchers excited about this trial?
Unlike standard treatments for sexual health that often involve pharmaceuticals like PDE5 inhibitors (such as Viagra or Cialis), this new approach uses geranylgeraniol (GG) sourced from annatto, a natural product. Researchers are excited about GG because it offers a potential alternative with a different mechanism of action, possibly interacting with the body's natural processes in a novel way. Additionally, GG is derived from a plant source, which may appeal to those seeking more natural treatment options.
What evidence suggests that Geranylgeraniol might be an effective treatment for sexual health function?
Research suggests that Geranylgeraniol (GG) might improve sexual health by balancing hormones. Although studies have not shown major changes in blood tests or hormone levels, GG is being explored for its unique mechanism. Early signs indicate it could positively affect sexual health. Participants in this trial will receive either Geranylgeraniol or a placebo. GG has a strong safety record, as it is considered safe even at much higher doses than those being tested. This treatment remains under study, so results are not yet confirmed, but the potential benefits make it worth exploring.13467
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Baseline Assessment
Participants are baseline assessed on sexual health function, body composition, blood chemistry, and grip strength
Treatment
Participants receive Geranylgeraniol or placebo supplementation with dose escalation over 8 weeks
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Geranylgeraniol (GG) sourced from Annatto
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Placebo Group
From weeks 1-4, participants will consume 150mg daily of a Geranylgeraniol (GG). For weeks 5-8, the dose will be escalated as participants will consume 300mg daily of GG.
From weeks 1-4, participants will consume 150mg daily of a visually identical placebo. For weeks 5-8, the dose will be escalated as participants will consume 300mg daily of placebo supplementation.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Applied Science & Performance Institute
Lead Sponsor
Citations
A 12-week evaluation of annatto tocotrienol supplementation ...
Annatto-derived tocotrienol up to 600 mg per day for 12 weeks appeared to be safe in postmenopausal osteopenic women, particularly in terms of liver and kidney ...
The Effects of Geranylgeraniol (GG) Sourced From Annatto ...
This study examines the effectiveness of Geranylgeraniol on sexual health in males and females, using an 8-week dose escalation, with a placebo group.
The Effects of Geranylgeraniol on Blood Safety and Sex ...
This study demonstrates that GG does not significantly change the composition of blood chemistry, hematology, or sex hormone profiles in adult males or females.
The Effects of Geranylgeraniol (GG) Sourced From Annatto ...
This trial tests Geranylgeraniol (GG) to improve sexual health in males and females, potentially by balancing hormones and using a unique mechanism.
A toxicological evaluation of geranylgeraniol
The no observed adverse effect level for systemic toxicity in the 90-day study was 725 mg/kg bw/day. Abstract. Geranylgeraniol (GGOH) is an isoprenoid compound ...
In Silico Studies with Geranylgeraniol and Tocotrienols
Annatto compounds, geranylgeraniol and tocotrienols, show potential against hyperlipidemia and chronic diseases, with anti-inflammatory and ...
Designs for Health Annatto-GG 300 - Geranylgeraniol ...
This supplement supports healthy aging, bone, muscle, and cellular energy, and promotes GG replenishment, with 300mg of trans-geranylgeraniol per serving.
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