Non-invasive Esophageal Testing for Swallowing Disorders
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores new methods to study esophageal motility issues using non-invasive tests. It employs two techniques, EESG (a type of non-invasive esophageal testing) and MESG, to measure electrical activity in the esophagus. Researchers are studying individuals with swallowing disorders such as achalasia and hypercontractile or spastic disorders, along with healthy individuals without gastrointestinal issues. The trial suits adults who have undergone standard tests for esophageal motility and have no known gut problems. As an unphased trial, it offers participants the chance to contribute to innovative research that could improve diagnostic methods for esophageal disorders.
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but if you are taking anticoagulants (blood thinners), you will not be able to participate.
What prior data suggests that these non-invasive esophageal testing methods are safe?
Studies have shown that both multichannel electroesophagogram (EESG) and magnetoesophagogram (MESG) provide safe and non-invasive ways to test esophageal function. These methods measure electrical and magnetic signals in the esophagus without requiring surgery or inserting anything into the body.
Because EESG and MESG do not involve cutting or entering the body, they are generally easy for people to tolerate. Research has not reported any negative effects from these tests, indicating their safety. Their non-invasive nature means they carry less risk compared to procedures involving direct contact with body tissues.
These methods are similar to other non-invasive tests like electrocardiograms (EKG) for the heart, which are widely used and have a proven safety record.12345Why are researchers excited about this trial?
Researchers are excited about the non-invasive esophageal testing techniques, EESG and MESG, because they offer a potential game-changer for diagnosing swallowing disorders like achalasia and hypercontractile/spastic disorders. Unlike traditional methods such as high-resolution manometry, which can be uncomfortable and invasive, EESG and MESG use electrical and magnetic signals to assess esophageal function in a much less intrusive way. This could lead to quicker, more comfortable, and perhaps more accurate diagnoses, making the patient's experience significantly better.
What evidence suggests that EESG and MESG are effective for swallowing disorders?
This trial will evaluate the use of electroesophagogram (EESG) and magnetoesophagogram (MESG) in diagnosing swallowing disorders. Participants with achalasia or hypercontractile/spastic disorders, along with healthy controls, will undergo testing with both EESG and MESG. Studies have shown that EESG helps understand esophageal movement issues in conditions like achalasia and hypercontractile disorders. Research indicates that these tests can complement standard assessments, offering a more complete picture of esophageal behavior. MESG is still under study, and data on its effectiveness for these conditions remains limited. Like EESG, MESG aims to assess esophageal movement non-invasively. Early findings suggest it could provide useful insights, but further research is needed to confirm its effectiveness.678910
Who Is on the Research Team?
Dhyanesh Patel, MD
Principal Investigator
Vanderbilt University Medical Center
Are You a Good Fit for This Trial?
This trial is for adults over 18 with no gastrointestinal issues, or those getting routine checks for esophageal motility. It's not for people with MRI contraindications like pacemakers, severe obesity, heart rhythm problems, anticoagulant use, or claustrophobia.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Testing
Participants undergo EESG and MESG testing to assess esophageal function and motility disorders
Follow-up
Participants are monitored for safety and effectiveness after testing
What Are the Treatments Tested in This Trial?
Interventions
- EESG
- High resolution manometry (HRM)
- MESG
Trial Overview
The study tests noninvasive methods to record esophageal activity in adults using EESG and MESG alongside High resolution manometry (HRM), which are techniques to measure muscle function and movements of the esophagus.
How Is the Trial Designed?
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Treatment groups
Active Control
Subjects who have undergone standard of care high resolution manometry that results in a diagnosis of achalasia will be given questionnaires and testing by electroesophagogram (EESG) and magnetoesophagogram (MESG).
Subjects who have undergone standard of care high resolution manometry that results in a diagnosis of hypercontractile/spastic disorder will be given questionnaires and testing by electroesophagogram (EESG) and magnetoesophagogram (MESG).
Healthy volunteers with no known gastrointestinal complications will be given questionnaires and testing by electroesophagogram (EESG) and magnetoesophagogram (MESG).
Find a Clinic Near You
Who Is Running the Clinical Trial?
Vanderbilt University Medical Center
Lead Sponsor
Citations
Management of Spastic Disorders of the Esophagus - PMC
In total, 13 of the 14 patients had LES dysfunction evident either on barium swallow or manometry, suggesting that the 2 techniques were complementary in ...
POEM for non-achalasia spastic oesophageal motility ...
The study reported a success rate of 58.3%, comparable to that observed in achalasia patients. Notably, symptom relief was more sustained in OGJOO patients when ...
Presence of esophageal contractility after achalasia ...
In a study of 122 achalasia patients, we found post-treatment contractile activity in 50% cases, facilitated when adequate EGJ opening was achieved.
Hypercontractile Esophagus: Clinical and Manometric ...
This study aims to investigate the clinical and manometric features of HE and evaluate treatment outcomes in a multicenter Korean cohort.
Hypercontractile esophageal motility disorder or functional ...
The surprising outcome of the study was that both active botulinum toxin treatment and sham treatment resulted in a significant reduction in ...
Use and Safety of Per-Oral Endoscopic Myotomy for Achalasia ...
This cohort study investigates the use, safety, and costs associated with the use of per-oral endoscopic myotomy for achalasia in the US.
7.
gastroenterologyadvisor.com
gastroenterologyadvisor.com/news/in-older-patients-with-achalasia-minimally-invasive-poem-is-very-successful/In Older Patients With Achalasia, Minimally Invasive POEM ...
In older patients with achalasia, peroral endoscopic myotomy was safe and effective, with success rates comparable to those in younger ...
Peroral endoscopic myotomy: 10-year outcomes from a ...
POEM is exceptionally safe and highly effective on long-term follow-up, with >90% clinical success at ≥5 years.
9.
researchgate.net
researchgate.net/publication/229433709_Progression_of_diffuse_esophageal_spasm_to_achalasia_Incidence_and_predictive_factorsProgression of diffuse esophageal spasm to achalasia
One study performed during the era of conventional manometry found that DES progresses to achalasia in 8% (1/12) of patients after a mean follow ...
Achalasia - Symptoms, diagnosis and treatment
Achalasia is an esophageal motor disorder characterized by a loss of esophageal peristalsis and failure of the lower esophageal sphincter to relax in response ...
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