Mango Intake for Immunity and Cognition

Overseen By Amandeep Wright, MPH

Age: 18 - 65

Sex: Any

Trial Phase: Academic

Sponsor: Loma Linda University

Must not be taking: Antibiotics, Corticoids

Disqualifiers: Mango allergy, Chronic diseases, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: Unknown

Duration: 12 weeks

54 Participants Needed

Trial Summary

Do I need to stop taking my current medications to join the trial?

The trial does not specify if you need to stop taking your current medications, but you cannot participate if you are using cognition or immune-boosting supplements, have recently taken antibiotics or corticoids, or have uncontrolled chronic diseases.

What data supports the effectiveness of the treatment Mango, Mangifera indica, Tommy Atkins mango for immunity and cognition?

Research shows that extracts from mango leaves, which are rich in a compound called mangiferin, can improve cognitive function in healthy adults. This suggests that mango components might have potential benefits for brain health. ^{1 2 3 4 5}

Is mango safe for human consumption?

Research shows that mango extracts, including those from leaves and immature fruits, are generally safe for consumption in humans and animals. Studies in rats and humans have not reported any significant adverse effects, indicating that mango is safe to consume. ^{1 2 6 7 8}

How does mango intake differ from other treatments for immunity and cognition?

Mango intake is unique because it uses natural bioactive compounds found in the fruit, such as mangiferin, which have antioxidant properties and may enhance cognitive function and immunity. Unlike conventional treatments, it focuses on dietary intake of whole fruit or extracts, offering a natural approach to improving health. ^{1 2 6 9 10}

What is the purpose of this trial?

The main objectives of our proposed study are to determine the effects of mango consumption on immune and cognitive functions in free-living college going young adults aged 18-30 years

Research Team

Sujatha Rajaram, PhD

Principal Investigator

Loma Linda University

Eligibility Criteria

This trial is for college students aged 18-30 years who don't regularly eat mangos or similar fruits like peaches and papayas. They shouldn't be taking supplements for cognition or immunity, have had recent antibiotics or steroids, suffer from uncontrolled chronic diseases, mental illnesses, clinical depression, or have a compromised immune system.

Inclusion Criteria

I am a college student between 18 and 30 years old.

Exclusion Criteria

I have recently taken antibiotics or steroids.

I am taking supplements for brain health or to boost my immune system.

Known intolerance or allergy to mangos

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants in the Mango group consume 1.5 cups of mangos daily for 12 weeks, while the control group abstains from eating mangos

12 weeks

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

Treatment Details

Interventions

• Mango

Trial Overview The study aims to see if eating mangos affects the immune system and brain function in young adults. Participants will include mango as part of their regular diet and researchers will monitor changes in their immunity and cognitive abilities.

Participant Groups

Group I: control group Active Control 1 Intervention

The control group will receive no dietary intervention. they will follow usual diet and abstain from eating mangos

Group II: Mango Group Active Control 1 Intervention

Participants in the Mango group will consume 1.5 cups of mangos for 12 weeks

Who Is Running the Clinical Trial?

Loma Linda University

Lead Sponsor

Trials

322

Recruited

267,000+

National Mango Board

Collaborator

Trials

7

Recruited

300+

Findings from Research

A 90-day toxicity study in Sprague Dawley rats showed that a hot-water extract of thinned immature mango fruits (TIMEx) is safe for consumption, with no deaths or significant behavioral changes observed at doses up to 2500 mg/kg body weight/day.

The study established a no-observed-adverse-effect level (NOAEL) of 2500 mg/kg/day for TIMEx, suggesting it could be a viable candidate for food applications.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Subchronic safety evaluation of hot-water extract from thinned immature mangos (Mangifera indica 'Irwin'): 90-days oral toxicity study in rats. Tajiri, H., Tanaka, W., Takashima, M., et al.[2021]

In a pilot study of 20 obese adults over 12 weeks, supplementation with 10 g/day of freeze-dried mango significantly reduced fasting blood glucose levels in both males and females, indicating potential benefits for blood sugar management.

While there were no significant changes in overall body weight or composition, males experienced a notable reduction in hip circumference, suggesting that mango supplementation may help with specific body measurements without negatively affecting weight.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Mango supplementation improves blood glucose in obese individuals. Evans, SF., Meister, M., Mahmood, M., et al.[2022]

References

1. Switzerland pubmed.ncbi.nlm.nih.gov

Acute Effects of a Polyphenol-Rich Leaf Extract of Mangifera indica L. (Zynamite) on Cognitive Function in Healthy Adults: A Double-Blind, Placebo-Controlled Crossover Study. [2021]

2. India pubmed.ncbi.nlm.nih.gov

Effects of Mangifera indica fruit extract on cognitive deficits in mice. [2022]

3. United States pubmed.ncbi.nlm.nih.gov

Multifunctional Effects of Mangosteen Pericarp on Cognition in C57BL/6J and Triple Transgenic Alzheimer's Mice. [2022]

4. United States pubmed.ncbi.nlm.nih.gov

Effects of water-soluble mangosteen extract on cognitive function and neuropsychiatric symptoms in patients with mild to moderate Alzheimer's disease (WECAN-AD): A randomized controlled trial. [2022]

5. Netherlands pubmed.ncbi.nlm.nih.gov

Alpha-mangostin attenuates brain inflammation induced by peripheral lipopolysaccharide administration in C57BL/6J mice. [2017]

6. England pubmed.ncbi.nlm.nih.gov

Mangos and their bioactive components: adding variety to the fruit plate for health. [2018]

7. Ireland pubmed.ncbi.nlm.nih.gov

Subchronic safety evaluation of hot-water extract from thinned immature mangos (Mangifera indica 'Irwin'): 90-days oral toxicity study in rats. [2021]

8. United States pubmed.ncbi.nlm.nih.gov

Mango supplementation improves blood glucose in obese individuals. [2022]

9. England pubmed.ncbi.nlm.nih.gov

Neuroprotective effects of mango cv. 'Ataulfo' peel and pulp against oxidative stress in streptozotocin-induced diabetic rats. [2021]

10. Switzerland pubmed.ncbi.nlm.nih.gov

Prospective Evaluation of Mango Fruit Intake on Facial Wrinkles and Erythema in Postmenopausal Women: A Randomized Clinical Pilot Study. [2021]