Mango Intake for Immunity and Cognition

SR
AW
Overseen ByAmandeep Wright, MPH
Age: 18 - 65
Sex: Any
Trial Phase: Academic
Sponsor: Loma Linda University
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores whether eating mangos can boost immune health and brain function. Participants will be divided into two groups: one will eat mangos regularly, while the other will not change their diet. College students who do not typically eat mangos or similar fruits and are not on special supplements are ideal candidates. As an unphased trial, this study provides a unique opportunity to contribute to new insights in nutrition and health.

Do I need to stop taking my current medications to join the trial?

The trial does not specify if you need to stop taking your current medications, but you cannot participate if you are using cognition or immune-boosting supplements, have recently taken antibiotics or corticoids, or have uncontrolled chronic diseases.

Is there any evidence suggesting that consuming mango is safe for young adults?

Research has shown that mango extracts, including mango leaves and unripe fruits, are generally safe for humans and animals. Mangoes contain important nutrients and antioxidants that protect cells.

Studies have not identified any serious side effects from consuming mangoes, suggesting that most people can eat them without issues. Including mangoes in the diet can help meet daily vitamin needs. Overall, mangoes are safe and offer health benefits, such as reducing inflammation and potentially helping to fight cancer.12345

Why are researchers excited about this trial?

Unlike typical treatments for boosting immunity and cognitive function, which often involve supplements or medications, this trial explores the potential benefits of simply consuming mangos. Researchers are excited about this approach because mangos are a natural source of vitamins, antioxidants, and fiber, which might enhance immune response and brain health without the side effects associated with pharmaceutical options. This treatment's uniqueness lies in its simplicity and accessibility, offering a delicious and holistic way to potentially improve health.

What evidence suggests that mango consumption might be effective for improving immunity and cognition?

Research suggests that eating mangos might improve the immune system and brain function. Some studies have found that mango leaf extract benefits brain function in both animals and people. Although specific information about how mango fruit directly affects immunity and cognition in humans is limited, mangos contain nutrients that could support a healthy immune system. In this trial, participants in the Mango group will consume 1.5 cups of mangos for 12 weeks to evaluate these potential benefits. The vitamins and antioxidants in mangos may boost overall health, possibly enhancing the immune system and brain function. Further research is underway to confirm these effects in young adults.13678

Who Is on the Research Team?

SR

Sujatha Rajaram, PhD

Principal Investigator

Loma Linda University

Are You a Good Fit for This Trial?

This trial is for college students aged 18-30 years who don't regularly eat mangos or similar fruits like peaches and papayas. They shouldn't be taking supplements for cognition or immunity, have had recent antibiotics or steroids, suffer from uncontrolled chronic diseases, mental illnesses, clinical depression, or have a compromised immune system.

Inclusion Criteria

I am a college student between 18 and 30 years old.

Exclusion Criteria

I have recently taken antibiotics or steroids.
I am taking supplements for brain health or to boost my immune system.
Known intolerance or allergy to mangos
See 2 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants in the Mango group consume 1.5 cups of mangos daily for 12 weeks, while the control group abstains from eating mangos

12 weeks

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Mango
Trial Overview The study aims to see if eating mangos affects the immune system and brain function in young adults. Participants will include mango as part of their regular diet and researchers will monitor changes in their immunity and cognitive abilities.
How Is the Trial Designed?
2Treatment groups
Active Control
Group I: control groupActive Control1 Intervention
Group II: Mango GroupActive Control1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Loma Linda University

Lead Sponsor

Trials
322
Recruited
267,000+

National Mango Board

Collaborator

Trials
7
Recruited
300+

Published Research Related to This Trial

In a pilot study of 20 obese adults over 12 weeks, supplementation with 10 g/day of freeze-dried mango significantly reduced fasting blood glucose levels in both males and females, indicating potential benefits for blood sugar management.
While there were no significant changes in overall body weight or composition, males experienced a notable reduction in hip circumference, suggesting that mango supplementation may help with specific body measurements without negatively affecting weight.
Mango supplementation improves blood glucose in obese individuals.Evans, SF., Meister, M., Mahmood, M., et al.[2022]
A 90-day toxicity study in Sprague Dawley rats showed that a hot-water extract of thinned immature mango fruits (TIMEx) is safe for consumption, with no deaths or significant behavioral changes observed at doses up to 2500 mg/kg body weight/day.
The study established a no-observed-adverse-effect level (NOAEL) of 2500 mg/kg/day for TIMEx, suggesting it could be a viable candidate for food applications.
Subchronic safety evaluation of hot-water extract from thinned immature mangos (Mangifera indica 'Irwin'): 90-days oral toxicity study in rats.Tajiri, H., Tanaka, W., Takashima, M., et al.[2021]

Citations

Mango Immunity and Cognition StudyThe primary goal of this study is to determine whether eating Mango daily for 12 weeks can improve immunity and cognition.
Mango Intake for Immunity and CognitionTrial Overview The study aims to see if eating mangos affects the immune system and brain function in young adults. Participants will include mango as part of ...
Immune and Cognitive Benefits of Mango Intake in Young ...The main objectives of our proposed study are to determine the effects of mango consumption on immune and cognitive functions in free-living college going young ...
Acute effects of mango leaf extract on cognitive function in ...Previous research has demonstrated that mango leaf extract (MLE) can beneficially modulate cognitive function in both animals and humans. This ...
The contribution of mango fruit (Mangifera indica L.) to ...The beneficial effects of mango fruit and its components have been studied on different non-communicable diseases such as obesity, type 2 diabetes mellitus, ...
Biological Active Ecuadorian Mango 'Tommy Atkins ...Other health-promoting compounds like tocopherols and polyphenols were also evaluated, as well as the in vitro antioxidant capacity of mango by-products.
Chemical Composition of Mango (Mangifera indica L.) FruitMango fruit has a high nutritional value and health benefits due to important components. The present manuscript is a comprehensive update on the composition of ...
Multifaceted Health Benefits of Mangifera indica L. (Mango)This review provides an overview of the antioxidant, anti-inflammatory, and anticancer properties of mango, a fruit that should be included in everyone's diet.
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