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MR Evaluation for Brain Health

N/A
Recruiting
Led By Petrice Cogswell, MD
Research Sponsored by Mayo Clinic
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
A healthy control will be defined as an otherwise healthy person who does not have a medical condition that affects brain function or have problems with concentration, memory, balance, or coordination.
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up at the time of mr exam, approximately one hour
Awards & highlights

Study Summary

This trial is testing a new way to detect Cerebral Spinal Fluid (CSF) flow in the brain to help with diagnosis and understanding of diseases that affect brain function.

Who is the study for?
This trial is for healthy individuals and those with suspected altered CSF dynamics, such as hydrocephalus or cognitive impairments like Alzheimer's. Participants should not have conditions affecting brain function or memory issues. Pregnant women, people needing sedation for MRI, or those with non-MRI compatible devices cannot join.Check my eligibility
What is being tested?
The study is testing a new MR imaging method to observe the flow of cerebrospinal fluid (CSF) in the brain. This could improve diagnosis and understanding of conditions like Alzheimer's Disease and Hydrocephalus that impact brain function.See study design
What are the potential side effects?
As this trial involves standard MRI procedures, side effects are minimal but may include discomfort from lying still during the scan or reactions to contrast agents if used—like mild pain, coldness at the injection site, or light-headedness.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am healthy with no brain function issues or problems with concentration, memory, balance, or coordination.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~at the time of mr exam, approximately one hour
This trial's timeline: 3 weeks for screening, Varies for treatment, and at the time of mr exam, approximately one hour for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
CSF flow measurement
Secondary outcome measures
Volume of CSF spaces
White matter disease

Trial Design

1Treatment groups
Experimental Treatment
Group I: MR brainExperimental Treatment3 Interventions
Participants will be asked to complete a MRI screening form to check for the presence of metallic implants and materials. People with pacemakers, aneurysm clips, and cochlear implants, or metal/foreign objects in their eyes cannot have an MRI and will not be able to participate in the study. Pre-menopausal females will be asked if they think they may be pregnant. If yes, a urine pregnancy test will be performed. Those who meet eligibility criteria for the study and have agreed to participate will be taken to the MRI suite when MR imaging of the brain will be performed.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Urine pregnancy test
2006
Completed Phase 3
~120

Find a Location

Who is running the clinical trial?

Mayo ClinicLead Sponsor
3,207 Previous Clinical Trials
3,767,090 Total Patients Enrolled
1 Trials studying Hydrocephalus
2 Patients Enrolled for Hydrocephalus
Petrice Cogswell, MDPrincipal InvestigatorMayo Clinic

Media Library

MR brain Clinical Trial Eligibility Overview. Trial Name: NCT04099823 — N/A
Hydrocephalus Clinical Trial 2023: MR brain Highlights & Side Effects. Trial Name: NCT04099823 — N/A
Hydrocephalus Research Study Groups: MR brain
MR brain 2023 Treatment Timeline for Medical Study. Trial Name: NCT04099823 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
MR Evaluation of Cerebrospinal Fluid (CSF) Dynamics
Petrice M. Cogswell 2019. "MR Evaluation of Cerebrospinal Fluid (CSF) Dynamics". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04099823.
All > Alzheimer Disease > Alzheimers Disease
~14 spots leftby Jan 2026
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