PRP in Hiatal Hernia Repair
(PPR-HHR Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial is testing whether using platelet rich plasma (PRP) with mesh in hiatal hernia surgery can improve healing and reduce hernia recurrence. The study involves adults with large hernias and looks at the effects of PRP on healing and recurrence rates. PRP is believed to enhance tissue healing, making the repair stronger. Platelet-rich plasma (PRP) has been underinvestigated for improving hernia repair outcomes, but it may enhance healing and reduce recurrence rates.
Are You a Good Fit for This Trial?
This trial is for adults with large hiatal hernias over 5cm, confirmed by specific imaging tests. It's not suitable for non-English speakers, those who've had previous antireflux surgery, diabetics, recent steroid users or cancer patients, pregnant or breastfeeding women, smokers, and people with low platelet counts or platelet dysfunction.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Patients undergo hiatal hernia repair with or without PRP application to the mesh
Follow-up
Participants are monitored for hernia recurrence and quality of life improvements
What Are the Treatments Tested in This Trial?
Interventions
- Platelet Rich Plasma
Platelet Rich Plasma is already approved in United States, European Union for the following indications:
- Facet-mediated lumbar low back pain
- Degenerative joint disease
- Chronic pain
- Orthopedic conditions
- Musculoskeletal disorders
- Pain management
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Southern California
Lead Sponsor