Total-Body PET Scan for Head and Neck Cancer
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial aims to understand the behavior of a radioactive sugar, called FDG, in people with head and neck cancer using a new whole-body scanner (Total Body PET/CT Imaging). Participants will undergo two sets of scans: one before starting their cancer treatment and another about 12 weeks after. This trial suits individuals with stage II-IVa head and neck cancer who can remain still for up to an hour during the scans. As an unphased trial, it offers a unique opportunity to contribute to innovative imaging research that could enhance future cancer diagnostics.
Do I need to stop my current medications for the trial?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the study team or your doctor.
What prior data suggests that this total-body PET/CT imaging is safe for head and neck cancer patients?
Research has shown that total-body PET/CT scans are safe and generally well-tolerated. These scans use a very small amount of radioactive material, which keeps the risk low. Current evidence suggests that PET/CT scans are low-risk procedures commonly used in medical settings for diagnosis.
The use of FDG, a type of radioactive sugar, in these scans is standard and has been shown to be very safe. Although there is some exposure to a small amount of radiation, the risks are considered minimal.
Overall, total-body PET/CT imaging is viewed as a safe option for patients, with few reports of side effects.12345Why are researchers excited about this trial?
Researchers are excited about total-body PET/CT imaging for head and neck cancer because it offers a comprehensive view of the entire body, potentially improving the detection of cancer spread compared to standard imaging techniques. Unlike traditional scans that focus on specific areas, this method captures detailed images of the whole body at multiple time points, allowing for better monitoring of how the cancer responds to treatment. This could lead to more personalized and effective treatment plans, ultimately enhancing patient outcomes.
What evidence suggests that total-body PET/CT imaging is effective for head and neck cancer?
Research has shown that a special type of scan called PET/CT, which uses a substance known as FDG, detects head and neck cancer more effectively than regular CT scans. Studies indicate that PET scans can detect cancer 87% of the time, compared to 62% for CT scans, making PET scans more effective at spotting cancer. In this trial, participants will undergo a total-body PET/CT scan, which reduces radiation exposure while still providing clear images. Overall, PET/CT is a powerful tool for detecting cancer and aiding doctors in planning effective treatments.678910
Who Is on the Research Team?
Tokihiro Yamamoto, PhD
Principal Investigator
University of California, Davis
Are You a Good Fit for This Trial?
This trial is for adults over 18 with Stage II-IVa head and neck cancer who are set to receive radiation therapy. Participants must be able to lie still for up to an hour, give informed consent, follow the study schedule, and fast as required. It's not for those who've had prior radiation or chemo that overlaps with this treatment area, have severe claustrophobia, are pregnant or breastfeeding, prisoners, children under 18, weigh over 240 kg, or have a medical condition that could affect their safety in the study.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Pre-Treatment PET Scan
Participants undergo a total-body PET/CT scan before treatment, involving FDG injection and three scans at different time points post-injection
Post-Treatment PET Scan
Participants undergo a total-body PET/CT scan 12 +/- 2 weeks after treatment, involving FDG injection and three scans at different time points post-injection
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Total Body PET/CT Imaging
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of California, Davis
Lead Sponsor
National Cancer Institute (NCI)
Collaborator
Colorado SPORE Developmental Research Program
Collaborator