Alpha Lipoic Acid to Decrease Pain and Side Effects in Concurrent Treatment of HNSCC
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial is testing alpha lipoic acid, an antioxidant supplement, in patients with head and neck cancer who are receiving treatment. The goal is to find the safest dose that helps protect cells and reduce inflammation. This could make the cancer treatment more effective and less harmful.
Will I have to stop taking my current medications?
The trial requires that you stop taking gabapentin, pregabalin, amitriptyline, nortriptyline, or duloxetine if you are currently using them.
Is Alpha Lipoic Acid safe for humans?
How does alpha-lipoic acid differ from other treatments for its condition?
Alpha-lipoic acid is unique because it acts as a powerful antioxidant, helping to neutralize harmful molecules in the body and regenerate other antioxidants like vitamins C and E. Unlike many treatments, it is both water and fat soluble, allowing it to work throughout the body, and it has potential benefits for a wide range of conditions, including diabetes, cardiovascular diseases, and neurodegenerative disorders.56789
What data supports the effectiveness of the drug Alpha Lipoic Acid?
Who Is on the Research Team?
Jessica McDermott
Principal Investigator
University of Colorado, Denver
Are You a Good Fit for This Trial?
Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive alpha lipoic acid during concurrent chemoradiation therapy, with dose escalation in a 3+3 design
Follow-up
Participants are monitored for safety and effectiveness after treatment, including progression-free survival and overall survival assessments
Long-term follow-up
Participants are monitored for overall survival and long-term safety
What Are the Treatments Tested in This Trial?
Interventions
- Alpha Lipoic Acid
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Colorado, Denver
Lead Sponsor
National Cancer Institute (NCI)
Collaborator
Cancer League of Colorado
Collaborator