Mango for Gut Microbiome

Age: 18 - 65

Sex: Any

Trial Phase: Academic

Sponsor: San Diego State University

Must not be taking: Antibiotics, Dietary supplements, others

Disqualifiers: Smoker, Pregnant, Mango allergy, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 4

Duration: 4 weeks

60 Participants Needed

Trial Summary

Will I have to stop taking my current medications?

If you need to take medications for metabolic disorders, mental health, or sexual health, you cannot participate in this trial. Otherwise, the protocol does not specify if you need to stop other medications.

Is mango consumption safe for humans?

A study on mango consumption for 6 weeks in healthy lean and obese individuals found it to be safe, as it focused on how mango affects gut bacteria without reporting any safety concerns. ^{1 2 3 4 5}

How does mango consumption affect gut health compared to other treatments?

Mango consumption is unique because it naturally enhances gut microbiome diversity and specific beneficial bacteria, which may improve gut health and offer potential benefits for chronic diseases. Unlike other treatments, mango's effects are linked to its polyphenols and dietary fiber, which act as prebiotics (substances that promote the growth of beneficial gut bacteria). ^{2 6 7 8 9}

What is the purpose of this trial?

The objective of the proposed research is to determine the effects of fresh mango consumption on gut microbiome, and its relationship with skin health, sexual and mental health in relatively healthy adults.

Eligibility Criteria

This trial is for generally healthy adults with a BMI between 20-40 kg/m2. It's not suitable for those allergic to mango or wheat, smokers, pregnant women, individuals on antibiotics, dietary supplements, or medications for metabolic, mental health and sexual health issues.

Inclusion Criteria

Generally healthy subjects

BMI 20-40 kg/m2

Exclusion Criteria

Allergy to mango or wheat

I am currently taking antibiotics.

Smoker

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants consume 100 kcal of either mango or low-fat cookies daily

4 weeks

Baseline and week 4 visits

Follow-up

Participants are monitored for changes in microbiome diversity, skin hydration, sexual health, and depression scores

4 weeks

Treatment Details

Interventions

• Low fat cookies
• Mango

Trial Overview The study aims to understand how eating fresh mangos affects the gut microbiome and its connection to skin health as well as mental and sexual wellbeing. Participants will consume either low-fat cookies or mangos to see the differences these foods make.

Participant Groups

Group I: Mango Experimental Treatment 1 Intervention

Subjects consume 100 kcal of mango daily for 4 weeks.

Group II: Low fat cookies Active Control 1 Intervention

Subjects consume 100 kcal of low-fat cookies daily for 4 weeks.

Who Is Running the Clinical Trial?

San Diego State University

Lead Sponsor

Trials

182

Recruited

119,000+

Findings from Research

The review highlights 14 successful case studies demonstrating how microbiome research has positively impacted the agrifood system, including disease management, soil fertilization, and food fermentation processes.

Microbiome applications are crucial for enhancing human and environmental health, with potential benefits such as improving food safety, developing probiotics, and preventing chronic diseases like obesity.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Microbiome Research as an Effective Driver of Success Stories in Agrifood Systems - A Selection of Case Studies. Olmo, R., Wetzels, SU., Armanhi, JSL., et al.[2022]

Daily consumption of mango for 6 weeks significantly increased the levels of gallotannin-metabolites in healthy lean individuals, suggesting enhanced absorption and potential health benefits from mango consumption.

The study also indicated that while both lean and obese participants showed increased urinary excretion of these metabolites, only lean individuals experienced a notable increase in beneficial short-chain fatty acids, highlighting a possible difference in health benefits based on body mass index (BMI).

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Body Mass Index as a Determinant of Systemic Exposure to Gallotannin Metabolites during 6-Week Consumption of Mango (Mangifera indica L.) and Modulation of Intestinal Microbiota in Lean and Obese Individuals. Barnes, RC., Kim, H., Fang, C., et al.[2019]

In a study of 31 healthy adults, recent consumption of high-intensity sweeteners like aspartame and acesulfame-K did not show significant differences in bacterial abundance in the gut microbiome.

However, there was a notable difference in bacterial diversity between consumers and nonconsumers of aspartame and acesulfame-K, suggesting that while sweeteners may not affect the quantity of gut bacteria, they could influence the variety of bacterial species present.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

High-intensity sweetener consumption and gut microbiome content and predicted gene function in a cross-sectional study of adults in the United States. Frankenfeld, CL., Sikaroodi, M., Lamb, E., et al.[2015]

In a study involving 16 obese individuals, rectal administration of buttermilk processed with medicinal plants led to significant reductions in body measurements and blood glucose levels after 15 days, indicating potential efficacy in weight management.

The treatment resulted in increased bacterial diversity in the gut microbiome on day 16, but this effect diminished by day 45, suggesting that repeated treatments may be necessary for sustained benefits.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Rectal administration of buttermilk processed with medicinal plants alters gut microbiome in obese individuals. Mane, S., Dixit, KK., Lathwal, N., et al.[2023]

Gut dysbiosis, or an imbalance in gut bacteria, is likely a precursor to the development of food allergies, suggesting that the timing of this imbalance is crucial for understanding allergy onset.

Research indicates that gut microbiota can influence food allergy susceptibility by affecting immune responses and intestinal health, and ongoing trials with probiotics and other interventions aim to translate these findings into effective treatments.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

The gut microbiome in food allergy. Zhao, W., Ho, HE., Bunyavanich, S.[2020]

In a 12-week study with 27 overweight/obese participants, fresh mango consumption improved gut microbiome diversity compared to low-fat cookies, indicating potential benefits for gut health.

Mango intake increased specific beneficial bacteria while slightly enhancing bowel movement frequency, suggesting that mango may positively influence gut health and warrant further investigation for chronic disease benefits.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

The effects of fresh mango consumption on gut health and microbiome - Randomized controlled trial. Asuncion, P., Liu, C., Castro, R., et al.[2023]

The indigestible fraction (IF) of both irradiated and non-irradiated mango-based bars positively influenced the growth of beneficial gut bacteria, such as Faecalibacterium and Bifidobacterium, during in vitro colonic fermentation.

Both types of mango bars enhanced carbohydrate metabolism pathways in the gut microbiota, suggesting potential benefits for preventing or treating metabolic dysbiosis, although further in vivo studies are needed to confirm these effects.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Changes in Intestinal Microbiota and Predicted Metabolic Pathways During Colonic Fermentation of Mango (Mangifera indica L.)-Based Bar Indigestible Fraction. Gutiérrez-Sarmiento, W., Sáyago-Ayerdi, SG., Goñi, I., et al.[2020]

In a study of 27 individuals with overweight and obesity consuming 280 g of mango pulp daily for 8 weeks, there was a significant 3.5% reduction in systolic blood pressure and a 10.5% reduction in 2-hour plasma glucose levels, indicating potential cardiometabolic benefits.

Mango consumption also led to enhanced gut microbiota diversity and changes in specific gut bacterial species, suggesting a link between mango intake and improved gut health, which may contribute to the observed health benefits.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Changes in systolic blood pressure, postprandial glucose, and gut microbial composition following mango consumption in individuals with overweight and obesity. Keathley, J., Kearney, M., Garneau, V., et al.[2022]

Mango polyphenols, particularly polymeric gallotannins, are influenced by intestinal microbiota, which helps convert them into absorbable metabolites that can promote gut health.

These polyphenols have been shown to have prebiotic effects, potentially reducing intestinal inflammation and enhancing intestinal integrity, contributing to overall digestive health.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Mango (Mangifera indica L.) Polyphenols: Anti-Inflammatory Intestinal Microbial Health Benefits, and Associated Mechanisms of Actions. Kim, H., Castellon-Chicas, MJ., Arbizu, S., et al.[2021]

References

1. Switzerland pubmed.ncbi.nlm.nih.gov

Microbiome Research as an Effective Driver of Success Stories in Agrifood Systems - A Selection of Case Studies. [2022]

2. Germany pubmed.ncbi.nlm.nih.gov

Body Mass Index as a Determinant of Systemic Exposure to Gallotannin Metabolites during 6-Week Consumption of Mango (Mangifera indica L.) and Modulation of Intestinal Microbiota in Lean and Obese Individuals. [2019]

3. United States pubmed.ncbi.nlm.nih.gov

High-intensity sweetener consumption and gut microbiome content and predicted gene function in a cross-sectional study of adults in the United States. [2015]

4. Switzerland pubmed.ncbi.nlm.nih.gov

Rectal administration of buttermilk processed with medicinal plants alters gut microbiome in obese individuals. [2023]

5. United States pubmed.ncbi.nlm.nih.gov

The gut microbiome in food allergy. [2020]

6. United States pubmed.ncbi.nlm.nih.gov

The effects of fresh mango consumption on gut health and microbiome - Randomized controlled trial. [2023]

7. Switzerland pubmed.ncbi.nlm.nih.gov

Changes in Intestinal Microbiota and Predicted Metabolic Pathways During Colonic Fermentation of Mango (Mangifera indica L.)-Based Bar Indigestible Fraction. [2020]

8. Canada pubmed.ncbi.nlm.nih.gov

Changes in systolic blood pressure, postprandial glucose, and gut microbial composition following mango consumption in individuals with overweight and obesity. [2022]

9. Switzerland pubmed.ncbi.nlm.nih.gov

Mango (Mangifera indica L.) Polyphenols: Anti-Inflammatory Intestinal Microbial Health Benefits, and Associated Mechanisms of Actions. [2021]