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Procedure

Laser Peripheral Iridotomy for Glaucoma

N/A

Recruiting

Led By Catherine Birt, MD, FRCSC

Research Sponsored by Sunnybrook Health Sciences Centre

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

clinical evidence of bilateral occludable angles (PACS) defined as: Peripheral anterior synechia (PAS) absent and trabecular meshwork not visible in ≥6 clock hours under non-indentation gonioscopy, Along with, absence of PAC or PACG, in both eyes.

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 3 months from baseline visit

Awards & highlights

Study Summary

This trial will compare the side effects and pain levels of those who have a clear indication for bilateral laser peripheral iridotomy (LPI) in the right or left eye.

Who is the study for?

This trial is for people with a condition where the eye's drainage angle is too narrow, risking glaucoma. They must have normal macular and optic nerve scans and no history of severe eye pressure or past surgeries. Both eyes should be at risk but not yet have full-blown glaucoma.Check my eligibility

What is being tested?

The study tests if there's a difference in visual disturbances or pain when making a small hole (LPI) with a laser in different parts of the iris to prevent glaucoma. Patients are randomly chosen to get LPI either above or on the side of their iris.See study design

What are the potential side effects?

Possible side effects include discomfort during the procedure, light flashes, blurry vision right after treatment, minor bleeding inside the eye, and increased eye pressure.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

My eye exam shows I have narrow angles in both eyes but no glaucoma.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 3 months from baseline visit

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~3 months from baseline visit

This trial's timeline: 3 weeks for screening, Varies for treatment, and 3 months from baseline visit for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Dysphotopsias noted from baseline visit before procedure till 3 months after procedure

Secondary outcome measures

Pain during the baseline visit procedure and recollection of pain till 3 months after procedure

Trial Design

2Treatment groups

Active Control

Group I: Superior LPI placementActive Control1 Intervention

Each participant will be randomized to receive an LPI placement superiorly in one eye.

Group II: Temporal LPI placementActive Control1 Intervention

Each participant will be randomized to receive an LPI placement temporally in one eye.

0 / 1Eligibility criteria met

Find a Location

Who is running the clinical trial?

Sunnybrook Health Sciences CentreLead Sponsor

656 Previous Clinical Trials

1,551,108 Total Patients Enrolled

Catherine Birt, MD, FRCSCPrincipal InvestigatorSunnybrook

1 Previous Clinical Trials

59 Total Patients Enrolled

Media Library

Yag Laser peripheral Iridotomy (Procedure) Clinical Trial Eligibility Overview. Trial Name: NCT04741919 — N/A

Angle-Closure Glaucoma Research Study Groups: Superior LPI placement, Temporal LPI placement

Angle-Closure Glaucoma Clinical Trial 2023: Yag Laser peripheral Iridotomy Highlights & Side Effects. Trial Name: NCT04741919 — N/A

Yag Laser peripheral Iridotomy (Procedure) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04741919 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the current enrollment size of this experiment?

"Affirmative. According to clinicaltrials.gov, this research study is actively enrolling participants and was initially posted on November 25th 2020. The project requires 200 volunteers from one healthcare site for completion."

Answered by AI

Is recruitment still open for this experiment?

"Per clinicaltrials.gov, this medical trial commenced on November 25th 2020 and is still recruiting patients. The study was last updated in May of 2022."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Superior vs Temporal Laser Peripheral Iridotomy in Primary Angle Closure Suspects (PACS)

Dr. Catherine Birt 2020. "Superior vs Temporal Laser Peripheral Iridotomy in Primary Angle Closure Suspects (PACS)". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04741919.