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Exercise Impact on Muscle Health in Aging
N/A
Recruiting
Led By Damien M Callahan, Ph.D.
Research Sponsored by University of Oregon
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Adults between the ages 18-35 or 65-80 years
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up one week after the participant undergoes the biopsies.
Awards & highlights
Study Summary
This trial looks at how age affects muscle size and strength, and how proteins in muscle may change with age.
Who is the study for?
This trial is for healthy adults who feel they are aging well, aged 18-35 or 65-80, willing to undergo muscle biopsies and exercise tests. They must speak English fluently. It's not suitable for those with severe joint issues, mental health risks like dementia, untreated endocrine diseases, allergies to lidocaine, serious uncontrolled hypertension, blood clotting disorders, major organ disease, diabetes, recent steroid use or cancer treatments (except certain skin cancers), significant weight loss recently, smoking within a year or current substance abuse.Check my eligibility
What is being tested?
The study focuses on how proteins in skeletal muscles change due to fatiguing exercises in the context of aging. The goal is to understand the link between these protein changes and muscle atrophy that comes with getting older.See study design
What are the potential side effects?
Since this trial involves exercise and muscle biopsies as interventions rather than drugs or medical procedures there may be some discomfort from the biopsy procedure such as pain at the site of incision and bruising.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I am either 18-35 or 65-80 years old.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ one week after the participant undergoes the biopsies.
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~one week after the participant undergoes the biopsies.
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Phosphorylation of myosin binding protein c (MyBP-C)
Secondary outcome measures
Muscle fiber Force
Muscle fiber Power
Muscle fiber Tension
+1 moreTrial Design
1Treatment groups
Experimental Treatment
Group I: FatigueExperimental Treatment1 Intervention
Volunteers will perform one-legged knee extension exercise until fatigue while seated on an ergometer. Volunteers will then undergo bilateral skeletal muscle biopsies of the vastus lateralis muscle in their thigh.
Find a Location
Who is running the clinical trial?
University of OregonLead Sponsor
80 Previous Clinical Trials
46,882 Total Patients Enrolled
Wu Tsai Human Performance AllianceUNKNOWN
National Institutes of Health (NIH)NIH
2,701 Previous Clinical Trials
7,506,826 Total Patients Enrolled
17 Trials studying Aging
3,859 Patients Enrolled for Aging
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- I have an untreated hormone-related condition.You have a problem with drinking alcohol or using drugs, or you drink more than the recommended amount.I have lost more than 5kg unexpectedly in the last year.I have been treated for cancer, excluding successful Mohs Surgery for skin cancer.I have a serious heart, liver, kidney, or lung condition.I have diabetes, whether I need insulin or not.You are currently a smoker or quit smoking within the past year.I have severe knee problems or have had a joint replacement.You have been diagnosed with a neuromuscular disorder.You have used anabolic steroids in the last six months.I have a known blood clotting disorder.You are allergic to lidocaine.My blood pressure is high and not well-managed (>140/90 mmHg).I am either 18-35 or 65-80 years old.I consider myself healthy.
Research Study Groups:
This trial has the following groups:- Group 1: Fatigue
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Does my individual profile meet the requirements for this medical experiment?
"The eligibility criteria for this trial necessitates that the participants have sarcopenia and are between 18 to 80 years of age. As such, there is room for 24 volunteers in total."
Answered by AI
Does the research include minors among its participants?
"This trial has an age bracket of 18 to 80 for potential participants. For those below the former and above the latter, there are 67 clinical trials specifically designed with youth in mind and 658 studies catered towards seniors."
Answered by AI
How many individuals are participating in this research endeavor?
"Affirmative. Clinicaltrials.gov attests to the fact that this trial began recruiting on November 6, 2017 and is still actively searching for 24 participants from one location. The data was last updated June 26th 2023."
Answered by AI
Are there vacancies in the research trial for volunteers?
"Affirmative. Clinicaltrials.gov confirms that this medical study, which was initially made available on November 6th 2017, is actively recruiting participants. 24 individuals must be recruited from 1 clinic location."
Answered by AI
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