Magnesium Sulfate for Bronchiolitis
What You Need to Know Before You Apply
What is the purpose of this trial?
The purpose of this study is to more rigorously evaluate the response to a single bolus of magnesium sulfate in a population of patients with moderate to severe bronchiolitis. The primary outcome will be to evaluate the effect of this therapy on clinical respiratory status. Secondary outcomes of interest will include the incidence of adverse effects and safety profile of magnesium bolus use in this population.
Will I have to stop taking my current medications?
The trial information does not specify whether participants need to stop taking their current medications.
Is magnesium sulfate safe for use in humans?
Magnesium sulfate has been studied for safety in various conditions, including asthma and bronchiolitis, and is generally considered safe when used appropriately. It has been used both intravenously and as an inhaled treatment, with studies indicating it can be safely administered outside of critical care settings.12345
How does the drug Magnesium Sulfate differ from other treatments for bronchiolitis?
Magnesium Sulfate is unique because it is often used for its muscle relaxant properties, which can help open up the airways in the lungs, potentially providing relief for bronchiolitis. Unlike other treatments that may focus on reducing inflammation or infection, Magnesium Sulfate works by relaxing the muscles around the airways, which can help improve breathing.678910
What data supports the effectiveness of the drug Magnesium Sulfate for treating bronchiolitis?
Research shows that both nebulized and intravenous magnesium sulfate can help improve breathing in children with bronchiolitis by reducing respiratory distress and the need for additional oxygen support. It has also been effective in quickly improving airflow in severe asthma cases, suggesting its potential benefit in similar respiratory conditions like bronchiolitis.1241112
Who Is on the Research Team?
John W Berkenbosch, MD
Principal Investigator
University of Louisville
Are You a Good Fit for This Trial?
This trial is for infants under 12 months old with moderate to severe bronchiolitis, admitted to the pediatric intensive care unit within the last 24 hours. Parents must consent for their child's participation. Infants with cyanotic heart disease, chronic lung disease, or unrepaired congenital heart disease cannot participate.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive a bolus of 50mg/kg Magnesium Sulfate or placebo over twenty minutes
Monitoring
Participants are monitored for vital signs and MPIS for six hours post-treatment
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Magnesium Sulfate
Magnesium Sulfate is already approved in United States, European Union, Canada for the following indications:
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Louisville
Lead Sponsor