Saline Flushing for Nephrostomy

Overseen By Yan Epelboym, MD, MPH

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: Brigham and Women's Hospital

Disqualifiers: Infection, Anaphylaxis, Pregnancy, Coagulopathy, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 2

Duration: 12 weeks

20 Participants Needed

Trial Summary

What is the purpose of this trial?

We are performing this research to study if routine flushing is necessary to prevent obstructions of a nephrostomy tube. This study will evaluate patients that have nephrostomy tube or will have nephrostomy tubes placed as part of their standard clinical care. If you agree to participate in this stuy, you will undergo randomized assignment to either continue to routinely flush your nephrostomy tube with normal saline or not to routinely flush your nephrostomy tube with normal saline. You will be in the study for approximately 3 months if you decide to stay for the whole study.

Eligibility Criteria

This trial is for patients who currently have or will soon have a nephrostomy tube placed as part of their standard care. The study aims to determine if routine saline flushing prevents tube obstructions.

Exclusion Criteria

I have a permanent blood clotting disorder.

History of anaphylaxis to iodinated contrast

Pregnant or intent to become pregnant during the study

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants are randomized to either routine flushing of nephrostomy tubes or no flushing for 12 weeks

12 weeks

1 visit (in-person) for nephrostomy tube placement or exchange

Follow-up

Participants are monitored for nephrostomy tube obstruction or dislodgement at routine exchange or earlier if complications arise

12 weeks

1 visit (in-person) at routine exchange or earlier if needed

Treatment Details

Interventions

• Routine Saline Flushing

Trial Overview The study randomly assigns participants to one of two groups: those who will flush their nephrostomy tubes with normal saline routinely, and those who won't flush at all. This process continues for about three months.

Participant Groups

Group I: No Flushing of Nephrostomy Experimental Treatment 1 Intervention

Subjects allocated to the study intervention group will not flush their nephrostomy tube during the duration of the research study

Group II: Routine Flushing of Nephrostomy Active Control 1 Intervention

Subjects in the routine flushing group will continue to flush their nephrostomy tubes once per day with 10mL of normal saline

Who Is Running the Clinical Trial?

Brigham and Women's Hospital

Lead Sponsor

Trials

1,694

Recruited

14,790,000+