Lean Beef for Heart Health and Gut Microbiome

Overseen By Jaapna Dhillon

Age: 18 - 65

Sex: Any

Trial Phase: Academic

Sponsor: University of Missouri-Columbia

Must not be taking: Antibiotics, Metabolism drugs

Disqualifiers: Diabetes, Hypertension, Gastrointestinal disease, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 3

Duration: 6 weeks

90 Participants Needed

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores how eating lean beef affects heart health and the gut microbiome. Participants will try different diets, including lean (93%) grain-fed beef, lean (93%) grass-fed beef, or plant-based meat, to determine if any of these options improve health markers related to heart and digestion. Individuals between 18 and 45 with a stable weight who are willing to adhere to a set diet may be suitable for this study. As an unphased trial, this study provides a unique opportunity to contribute to understanding the impact of diet on health.

Will I have to stop taking my current medications?

The trial does not specify if you need to stop taking your current medications, but you cannot participate if you have recently started medications that affect metabolism or appetite, or if you are on drug therapy for certain heart conditions.

Is there any evidence suggesting that this trial's treatments are likely to be safe?

Research has shown that most people can eat lean beef, whether grass-fed or grain-fed, without any problems. Including lean red meat in the diet may improve some heart health risk factors. For instance, one study found that eating lean red meat could benefit gut and heart health.

Grass-fed beef might have less fat and fewer calories than other types of beef, which can be helpful. However, both grass-fed and grain-fed beef contain saturated fat, which can impact cholesterol levels. Strong evidence does not support the idea that grass-fed beef is healthier than grain-fed beef.

In general, lean beef is safe to eat as part of a balanced diet. Major reports of negative effects from eating lean beef are lacking. For specific health concerns, consulting a healthcare professional before changing the diet is advisable. ^{1 2 3 4 5}

Why are researchers excited about this trial's treatments?

Researchers are excited about evaluating lean beef and plant-based meat for heart health and gut microbiome because they explore dietary impacts on these areas in ways that typical treatments, like cholesterol-lowering drugs or probiotics, do not. Lean beef, both grain-fed and grass-fed, is being studied for its potential benefits on heart health and gut flora, focusing on how different feeding practices might influence these effects. Meanwhile, plant-based meat offers a macronutrient-matched alternative that could provide similar benefits without animal products, potentially appealing to those looking to reduce meat consumption. This trial could uncover new, accessible dietary strategies for improving heart and gut health that differ from traditional medication or supplements.

What evidence suggests that this trial's treatments could be effective for heart health and gut microbiome?

This trial will compare the effects of different types of meat on heart health and the gut microbiome. Research has shown that lean grass-fed beef, one of the treatments in this trial, might be healthier than grain-fed beef due to its lower levels of unhealthy fats and higher levels of beneficial fats, which support heart health. Studies have found that grass-fed beef offers a healthier fat composition that can help reduce the risk of heart disease. Lean grain-fed beef, another treatment option in this trial, also supports heart health when included in a balanced diet. It has been linked to a greater variety of beneficial gut bacteria, which is important for gut health. Consuming either type of lean beef as part of a healthy diet does not appear to harm heart or gut health. Additionally, this trial will include a plant-based meat option to compare its effects on heart and gut health. ^{1 3 4 6 7}

Who Is on the Research Team?

Jaapna Dhillon, PhD

Principal Investigator

University of Missouri-Columbia

Are You a Good Fit for This Trial?

This trial is for adults aged 18-45 with a BMI of 18-35 who are non-smokers, have stable weight and diet, and will follow the study plan. It's not for those using drugs, with taste/smell issues, heart diseases, uncontrolled high blood pressure, food allergies relevant to the study foods, gut problems or recent antibiotic use.

Inclusion Criteria

BMI: 18-35 kg/m2

Willingness to consume study foods

Willing to comply with study protocol

Exclusion Criteria

Illicit drug use

I have problems with my taste or smell.

I have diabetes.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants are randomized to consume either lean grain-fed beef, lean grass-fed beef, or plant-based meat for 6 weeks. Outcomes assessed include metabolic, inflammatory, and gut microbiome markers.

6 weeks

3 visits (in-person) at baseline, week 3, and week 6

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

• Lean (93%) Grain-Fed Beef
• Lean (93%) Grass-Fed Beef
• Plant-Based Meat

Trial Overview

The study examines how eating lean grass-fed beef or grain-fed beef compares to plant-based meat in affecting heart health and gut bacteria. Participants will consume assigned foods as part of their regular diet.

How Is the Trial Designed?

Group I: Lean (≥90%) Grass-Fed Beef Experimental Treatment 1 Intervention

The quantity of beef will be adjusted or normalized based on their individual energy requirements. The specified amount will be 4 oz. per day or 28 ounces per week for participants with an energy requirement of 2000 kcal. Participants will consume meals for six weeks.

Group II: Lean (≥90%) Grain-Fed Beef Experimental Treatment 1 Intervention

The quantity of beef will be adjusted or normalized based on their individual energy requirements. The specified amount will be 4 oz. per day or 28 ounces per week for participants with an energy requirement of 2000 kcal. Participants will consume meals for six weeks.

Group III: Plant-Based Meat Active Control 1 Intervention

Plant-based meat (beyond meat product) would be macronutrient matched to the same quantities of meat prescribed for a given energy level. Participants will consume meals for six weeks.

Who Is Running the Clinical Trial?

University of Missouri-Columbia

Lead Sponsor

Trials

387

Recruited

629,000+

Published Research Related to This Trial

In a study involving 45 young Chinese volunteers, those with lower BMI showed greater sensitivity in their gut metabolites to changes in diet, indicating that body weight may influence how the gut microbiota responds to meat consumption.

Switching from a beef-based diet to a chicken-based diet resulted in reduced inflammation-related blood markers, particularly in individuals with higher BMIs, suggesting that a chicken-based diet may be safer and less inflammatory for those with higher body weight.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Body weight index indicates the responses of the fecal microbiota, metabolome and proteome to beef/chicken-based diet alterations in Chinese volunteers. Zhao, D., Shan, K., Xie, Y., et al.[2022]

Plant-based meat substitutes are generally lower in kilojoules and saturated fat but higher in carbohydrates and sugars compared to equivalent meat products, indicating a potential for healthier options.

Despite the growth in plant-based products, many are high in sodium and lack essential nutrients like vitamin B12, iron, and zinc, emphasizing the need for better nutritional guidelines in their development.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Plant-Based Meat Substitutes in the Flexitarian Age: An Audit of Products on Supermarket Shelves. Curtain, F., Grafenauer, S.[2020]

Plant-based meat (PBM) products generally have a better nutrient profile than equivalent meat products, showing lower energy density, total fat, saturated fat, and higher fiber content based on a survey of 207 PBM and 226 meat products in the UK.

Despite their advantages, many PBM products still contain high levels of salt, with nearly 75% not meeting the UK's salt targets, indicating a need for improvement in their nutritional quality.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Nutritional Quality of Plant-Based Meat Products Available in the UK: A Cross-Sectional Survey. Alessandrini, R., Brown, MK., Pombo-Rodrigues, S., et al.[2022]

Meat is a rich source of essential nutrients that are hard to obtain from other foods, but industrially processed meats may contain preservatives like salts that could negatively impact health.

Current evidence does not clearly link saturated fat from meat to cardiovascular disease or diabetes, indicating a need for more high-quality research to better understand the health effects of meat consumption.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Meat and Human Health-Current Knowledge and Research Gaps. Geiker, NRW., Bertram, HC., Mejborn, H., et al.[2021]

A systematic review of 15 studies found that short-term beef consumption (1-4 weeks) had little to no significant effect on gut microbiota profiles in humans, suggesting that the impact of beef on gut health may be minimal at typical consumption levels.

Most existing research focused on high beef intake (240-380 g/d) and did not address recommended dietary amounts, indicating a significant gap in understanding how moderate beef consumption interacts with gut microbiota and overall health.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Systematic Review of Beef Protein Effects on Gut Microbiota: Implications for Health. Albracht-Schulte, K., Islam, T., Johnson, P., et al.[2023]

Plant-predominant diets can offer health and environmental benefits, and guidance is needed for consumers transitioning away from animal products, as many currently rely heavily on animal protein.

Plant-based meat alternatives (PBMAs) made from legumes could help facilitate this transition by mimicking the taste and texture of meat, while also being fortified with essential nutrients, although their health benefits compared to whole legumes still need further investigation.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Perspective: Plant-Based Meat Alternatives Can Help Facilitate and Maintain a Lower Animal to Plant Protein Intake Ratio. Messina, M., Duncan, AM., Glenn, AJ., et al.[2023]

In a study involving 23 men, adding high-fat ground beef (HFB) to their diet improved vascular function, specifically enhancing flow-mediated dilation (FMD) and lowering blood pressure without negatively affecting overall vascular health.

Both low-fat and high-fat ground beef did not harm vascular function, suggesting that red meat can be included in a diet without adverse effects, and the benefits of HFB may be linked to reductions in LDL cholesterol levels.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Assessment of Vascular Function in Response to High-Fat and Low-Fat Ground Beef Consumption in Men. Lytle, JR., Stanelle, ST., Martin, SE., et al.[2023]

Plant-based meat analogues (PBMAs) generally offer better nutritional quality compared to meat, with higher fiber content (15% vs 0%) and lower saturated fat (4% vs 15%) per 100g, making them healthier options.

PBMAs also tend to have higher iron content than meat, although the overall nutrition quality varies among different types of PBMAs, such as mince, bite/fillet, and nugget analogues, which were identified as the healthiest categories.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Nutritional assessment of plant-based meat analogues on the Swedish market. Bryngelsson, S., Moshtaghian, H., Bianchi, M., et al.[2022]

A systematic review of 85 studies, including 13 randomized controlled trials, found that meat intake can significantly alter gut microbiota composition, with higher meat consumption generally reducing certain beneficial bacteria like Anerostipes and Faecalibacterium while increasing others like Roseburia.

The research highlights inconsistencies in how different types of meat affect gut bacteria, indicating a need for more targeted studies to better understand the specific impacts of various meat subtypes on gut health.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Meat Consumption and Gut Microbiota: a Scoping Review of Literature and Systematic Review of Randomized Controlled Trials in Adults. Wang, Y., Uffelman, CN., Bergia, RE., et al.[2023]

Mixing fat from grain-fed beef or pork with grass-fed beef did not significantly increase microbial counts in ground meat, indicating safety in terms of microbial quality.

Consumer preference tests showed that adding fat from grain-fed steers to grass-fed beef improved the taste, suggesting it could be a viable way to enhance the palatability of grass-fed beef products.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Microbiological and Sensory Characteristics of Patty Formulations Containing Beef From Grass-Fed Steers and Fat Beef or Pork Trim. Chen, ME., Davidson, PM., Riemann, MJ.[2023]

Grass-fed beef contains significantly less total fat and saturated fatty acids compared to grain-fed beef, which may lead to a more favorable lipid profile and potential health benefits.

Grass-fed beef is richer in beneficial long-chain omega-3 polyunsaturated fatty acids (PUFAs) and trans-vaccenic acid, which could help reduce the risk of diseases like cancer and cardiovascular disease, while grain-fed beef has higher levels of monounsaturated fatty acids that also support heart health.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Fatty Acid Composition of Grain- and Grass-Fed Beef and Their Nutritional Value and Health Implication. Nogoy, KMC., Sun, B., Shin, S., et al.[2022]

Citations

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Healthy Dietary Patterns with and without Meat Improved ...

This study provides novel insights into the effects of including lean, unprocessed beef in a HDP on cardiometabolic disease risk factors because ...

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Lean red meat in balanced diet supports gut and heart health, study reveals · Balanced diets with lean red meat support gut and heart health.

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Heart-Healthy Eating With a Little Beef Still Beats Average ...

A controlled-feeding trial finds gut microbiota diversity increased after Mediterranean-style diets, with minimal to moderate amounts of beef ...

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withpower.com/trial/phase-diet-intervention-4-2024-1bd2b

Lean Beef for Heart Health and Gut Microbiome

Trial Overview The study examines how eating lean grass-fed beef or grain-fed beef compares to plant-based meat in affecting heart health and gut bacteria.

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sciencedirect.com

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Industry study sponsorship and conflicts of interest on the ...

All independent studies reported either unfavorable (73.3%) or neutral (26.7%) cardiovascular outcomes when consuming unprocessed red meat. Conversely, all ...

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New study highlights role of lean red meat in gut and heart ...

A recent study 1 from Purdue University scientists reveals following a consistent dietary pattern that features lean red meat can contribute to gut microbiota ...

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Fatty Acid Composition of Grain- and Grass-Fed Beef ...

Health claims have reported that grass-fed beef showed 62% lower fat content, 65% lower SFA, and greater concentrations of omega-3 fatty acids and conjugated ...