Interpersonal Psychotherapy - Adolescent Skills Training for Depression

Recruiting · Any Age · All Sexes · Philadelphia, PA

This study is evaluating whether a school-based program may help prevent depression in adolescents.

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About the trial for Depression

Eligible Conditions
Depressive Symptomatology · Depression

Treatment Groups

This trial involves 2 different treatments. Interpersonal Psychotherapy - Adolescent Skills Training is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Main TreatmentA portion of participants receive this new treatment to see if it outperforms the control.
Interpersonal Psychotherapy - Adolescent Skills Training
Control TreatmentAnother portion of participants receive the standard treatment to act as a baseline.
Services as usual


This trial is for patients born any sex of any age. There are 5 eligibility criteria to participate in this trial as listed below.

Inclusion & Exclusion Checklist
Mark “yes” if the following statements are true for you:
should be obtained when conducting research with minors Whenever someone is conducting research with minors, they should get both parental/guardian permission and the child's assent/consent. show original
The person has at least 16 on the CES-D scale and two symptoms that are on the threshold or subthreshold level for the K-SADS-PL scale. show original
in the Study The study analyzed the associations between adolescent and parent Participants in the study show original
Many adolescents in 9th or 10th grade are around the ages of 14 to 17. show original
The adolescent must be able to speak English; the parents must be able to speak either English or Spanish. show original
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Odds of Eligibility
Be sure to apply to 2-3 other trials, as you have a low likelihood of qualifying for this one.Apply To This Trial
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Approximate Timelines

Please note that timelines for treatment and screening will vary by patient
Screening: ~3 weeks
Treatment: varies
Reporting: Baseline, 2 month, 3 month, 9 month, 15 month
Screening: ~3 weeks
Treatment: Varies
Reporting: Baseline, 2 month, 3 month, 9 month, 15 month
This trial has approximate timelines as follows: 3 weeks for initial screening, variable treatment timelines, and reporting: Baseline, 2 month, 3 month, 9 month, 15 month.
View detailed reporting requirements
Trial Expert
Connect with the researchersHop on a 15 minute call & ask questions about:
- What options you have available- The pros & cons of this trial
- Whether you're likely to qualify- What the enrollment process looks like

Measurement Requirements

This trial is evaluating whether Interpersonal Psychotherapy - Adolescent Skills Training will improve 5 primary outcomes, 10 secondary outcomes, and 4 other outcomes in patients with Depression. Measurement will happen over the course of Weekly during IPT-AST.

Logs will track youth participation in IPT-AST and clinician attendance to IPT-AST consultation as one indicator of feasibility (implementation)
Fidelity to the intervention
The IPT-AST Fidelity Checklist will be completed by counselors and consultant to rate fidelity to IPT-AST intervention; adherence in each session is rated as a percent adherent; quality of session is also rated as percent; higher scores indicate greater adherence and quality (implementation)
Patterns in qualitative data
Qualitative interviews will be conducted with IPT-AST stakeholders to gather information on implementation of IPT-AST; this is a qualitative interview which will be coded for key themes
Onset of depression diagnoses
The onset of diagnoses/change in depression diagnoses during the study period from eligibility to the 15 month assessment will be assessed by the Schedule for Affective Disorders and Schizophrenia for School-Age Children (K-SADS-PL)
Change in school attendance
Impact of the intervention on school attendance will be examined by accessing school records and looking at change in attendance from baseline through 15 months.
Number of disciplinary incidents
Impact of the intervention on school disciplinary incidents will be examined by accessing school records and looking at number of new disciplinary incidents from baseline to the 15 month assessment
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Patient Q & A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is depression?

Symptoms of depression can last for quite some time. It can affect those of all ages, and in all contexts. If not properly treated, depression can cause serious disruption in daily functioning.

Anonymous Patient Answer

What are common treatments for depression?

There are some clear differences between the treatments used by Canadian doctors and patients: first-line treatments were more commonly used by Canadian patients. More effective treatments are more used by Canadian doctors. In the case of antidepressants, one third of patients were prescribed more efficacious agents, and one third were prescribed antidepressants that had not been proven for their efficacy. Although psychiatrists do report receiving and providing a variety of treatments, and patients do report feeling better after receiving treatments, the data also shows that not all patients are properly treated and that there are no standardized protocols for how they receive the treatment. Patients should start with the least efficacious treatments they can afford.

Anonymous Patient Answer

How many people get depression a year in the United States?

The lifetime prevalence of major depressive episode within the U.S. population exceeds 2% (2.0%). This rate is similar to estimates of lifetime prevalence of major depression among all cultures, and is higher than many previous estimates.

Anonymous Patient Answer

What causes depression?

Depression should not be oversimplified to be explained by a simple chemical imbalance in the brain. Instead, depression is likely to be more complicated with a multiplicity of contributing factors.

Anonymous Patient Answer

What are the signs of depression?

Symptoms of depression are present in up to half of those with migraine. Mood symptoms should be screened for in those with migraine. Treatment of the migraine is not required to treat depression.

Anonymous Patient Answer

Can depression be cured?

There is no evidence from this large national, randomised study that a single intervention (interferon or antidepressant medication) is effective in all aspects of depression as a whole. The majority will relapse at some point.

Anonymous Patient Answer

What is the primary cause of depression?

The first cause of depression is the death of a loved one, most commonly a parent, or a romantic partner, with a rate of around 50%. The second cause is the loss of a loved friend. About 15% of the population gets depression every year, and this varies over time and from place to place. The third major cause is financial problems, such as unemployment, insufficient income, or an unfavourable relationship with a spouse or partner. Around 5% of people suffer from depression or a recurrence of depression once a year or more often, and about 6% suffer from moderate or serious depression every year, or more often. The fourth cause of depression is a loss of a job, with a rate of around 3%.

Anonymous Patient Answer

Who should consider clinical trials for depression?

Patient advocacy groups and patients' organizations often report that trials' investigators focus on inclusion criteria based on symptom profiles of the patients they enroll. The evidence obtained from these trials is most likely to benefit the most patients in clinics where patients are very ill with severe depression, but also benefit the most patients in practices where the majority of patients are not severely ill but are nonetheless depressed. There is therefore important potential for improving access to clinical trials in psychiatry by increasing participation by disadvantaged patients whose symptoms are more representative of patients the investigators wish to study in clinical trials.

Anonymous Patient Answer

How does interpersonal psychotherapy - adolescent skills training work?

It is possible that interpersonal psychotherapy can improve psychological outcomes in depressed adolescents with interpersonal problems compared to control groups. It is also possible that group skills training may help alleviate some of the interpersonal and emotional difficulties faced by adolescents.

Anonymous Patient Answer

What is the latest research for depression?

A recent review of antidepressant agents concluded that 5-HT antagonists and serotonin-norepinephrine reuptake inhibitors have greater efficacy and fewer side effects than SSRIs and SNRIs in the treatment of depression. At this time, the evidence supports the use of 5-HT antagonists and SNRIs in the treatment of depression in the elderly. Evidence from trials with serotonin and norepinephrine reuptake inhibitors (SNRIs) suggests that the efficacy of antidepressant agents may vary with age and gender. Evidence from trials with SSRIs and SNRIs suggests that the efficacy of antidepressant agents may vary with baseline depression severity, with the strongest antidepressant efficacy occurring in patients with moderate or severe depression.

Anonymous Patient Answer

Is interpersonal psychotherapy - adolescent skills training safe for people?

Interpersonal psychotherapy is feasible for adults and adolescents with similar needs and characteristics. Given their strong commitment and personal integrity, individuals of this generation may lend themselves most to the development of personal contact sessions using a psychodynamic model of care.

Anonymous Patient Answer

Does interpersonal psychotherapy - adolescent skills training improve quality of life for those with depression?

This is a pilot research study that will determine whether enhancing the core interpersonal skills learned in a group setting with adolescent skills training has an impact on the degree to which participants experience improvements in quality of life. Preliminary data suggest that increased interpersonal skills in group treatment may lead to improvements in social and interpersonal functioning.

Anonymous Patient Answer
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