Daytime Bright Light for Delirium

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Delirium+2 More
Daytime Bright Light - Device
Eligibility
18+
All Sexes
What conditions do you have?
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Study Summary

This trial will study if daytime bright light exposure can help reduce delirium symptoms.

Eligible Conditions
  • Delirium
  • Circadian Rhythm Disorders

Treatment Effectiveness

Study Objectives

2 Primary · 10 Secondary · Reporting Duration: Study Day 1-30 (to study day 5 or MICU discharge whichever is longer, patients will be censored at hospital discharge).

Study Day 1
Feasibility, Patient Acceptance
Day 1
Days of Delirium
Day 5
Circadian Alignment
Circadian Alignment, Secondary Measures, Body surface temperature gradient
Heart rate
Circadian Alignment, Secondary Measures, urinary 6-sulfatoxymelatonin.
Sleep Efficiency
Total Sleep
Day 5
Feasibility, Intervention Fidelity
Feasibility, Intervention Sustainability
Feasibility, Patient Tolerance Symptoms
Feasibility, Patient Tolerance Time

Trial Safety

Trial Design

2 Treatment Groups

Usual Light
1 of 2
Bright Light
1 of 2
Active Control
Experimental Treatment

120 Total Participants · 2 Treatment Groups

Primary Treatment: Daytime Bright Light · No Placebo Group · N/A

Bright Light
Device
Experimental Group · 1 Intervention: Daytime Bright Light · Intervention Types: Device
Usual Light
Device
ActiveComparator Group · 1 Intervention: Usual Light · Intervention Types: Device

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: study day 1-30 (to study day 5 or micu discharge whichever is longer, patients will be censored at hospital discharge).

Who is running the clinical trial?

Yale UniversityLead Sponsor
1,666 Previous Clinical Trials
21,074,670 Total Patients Enrolled
5 Trials studying Delirium
2,205 Patients Enrolled for Delirium
Melissa Knauert, MD, PhDPrincipal InvestigatorYale University
2 Previous Clinical Trials
100 Total Patients Enrolled

Eligibility Criteria

Age 18+ · All Participants · 3 Total Inclusion Criteria

Mark “yes” if the following statements are true for you:
You are admitted to the hospital within 30 hours of enrollment.
You are expected to say in the MICU ≥24 hours after enrollment.

About The Reviewer

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 5th, 2021

Last Reviewed: October 3rd, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.