Photon for Breast Cancer

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Breast Cancer+1 More
Proton - Radiation
Eligibility
18+
All Sexes
What conditions do you have?
Select

Study Summary

This trial is testing whether proton therapy or photon therapy is better for treating breast cancer. It will follow patients for side effects, quality of life, and cancer control.

Eligible Conditions
  • Breast Cancer

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

1 Primary · 5 Secondary · Reporting Duration: 15 years

10 years
Effectiveness of proton therapy vs. photon therapy
15 years
Long Term Survival
5 years
Disease Control
Fatigue
Quality of Life
Radiation Dose and Quality of Life and Cardiac Toxicity

Trial Safety

Trial Design

2 Treatment Groups

Photon
1 of 2
Proton
1 of 2

Active Control

1278 Total Participants · 2 Treatment Groups

Primary Treatment: Photon · No Placebo Group · N/A

Photon
Radiation
ActiveComparator Group · 1 Intervention: Photon · Intervention Types: Radiation
Proton
Radiation
ActiveComparator Group · 1 Intervention: Proton · Intervention Types: Radiation

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: 15 years

Who is running the clinical trial?

Abramson Cancer Center of the University of PennsylvaniaLead Sponsor
347 Previous Clinical Trials
83,554 Total Patients Enrolled
40 Trials studying Breast Cancer
34,031 Patients Enrolled for Breast Cancer
Patient-Centered Outcomes Research InstituteOTHER
492 Previous Clinical Trials
29,826,423 Total Patients Enrolled
7 Trials studying Breast Cancer
1,496,932 Patients Enrolled for Breast Cancer
Justin Bekelman, MDPrincipal InvestigatorAbramson Cancer Center of the University of Pennsylvania
2 Previous Clinical Trials
1,193 Total Patients Enrolled
Oren Cahlon, MDStudy ChairMemorial Sloan Kettering Cancer Center
Shannon MacDonald, MDStudy ChairMassachusetts General Hospital
2 Previous Clinical Trials
65 Total Patients Enrolled

Eligibility Criteria

Age 18+ · All Participants · 10 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
The patient must have a relevant history and physical examination within 90 days prior to registration.
The individual is asymptomatic or has symptoms but is still capable of caring for themselves within the last 90 days.
People with invasive breast cancer who have had surgery to remove their breasts, either through mastectomy or lumpectomy, are included in this study.
The patient requires radiation therapy to the chest wall and lymph nodes, including treatment to the internal mammary nodes.
If a patient's insurance will not cover a specific treatment in this study, the patient is responsible for paying for that treatment
Patients who have undergone lumpectomy are allowed to have any type of mastectomy or reconstruction
There are no breast size limitations for patients who have undergone lumpectomy.
Patients with left- or right-sided breast cancer clinical or pathologic stage I, II, III, or loco-regionally recurrent at time of diagnosis are eligible for the study
Patients with bilateral breast cancer will be stratified into two groups: those with cancer on the left side and those with cancer on the right side.

About The Reviewer

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 5th, 2021

Last Reviewed: November 24th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.