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fMRI for Brain Cancer

N/A

Waitlist Available

Led By Andrei Holodny, MD

Research Sponsored by Memorial Sloan Kettering Cancer Center

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Patients must be able to perform the language paradigms on cue while inside the scanner

Patients between the ages of 18 and 80 years

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 2 years

Awards & highlights

Study Summary

This trial will test whether adding an imaging technique called breath-holding functional magnetic resonance imaging (BH fMRI) to the standard approach improves accuracy.

Who is the study for?

This trial is for adults aged 18-80 with brain tumors near areas responsible for speech or movement, who can follow language tasks during an MRI scan. It's not suitable for those with claustrophobia, anxiety preventing MRI exams, pacemakers (unless MRI safe), pregnant/nursing women, and individuals unable to perform required tasks due to physical or cognitive limitations.Check my eligibility

What is being tested?

The study tests the accuracy of breath-holding fMRI compared to standard imaging in locating brain functions affected by tumors. Researchers aim to determine if this additional imaging technique provides better results than the current standard alone.See study design

What are the potential side effects?

There are no direct side effects from participating in this trial as it involves non-invasive imaging techniques. However, participants may experience discomfort from lying still inside the scanner and performing specific language paradigms.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I can follow language tasks as instructed during a scan.

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I am between 18 and 80 years old.

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I have or might have a brain tumor such as glioma, meningioma, or cancer that has spread to my brain.

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I am between 18 and 80 years old.

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My tumor is located in a specific part of my brain related to speech or movement.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 2 years

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~2 years

This trial's timeline: 3 weeks for screening, Varies for treatment, and 2 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Number of patients that have false negative results

Trial Design

1Treatment groups

Experimental Treatment

Group I: Functional Magnetic Resonance Imaging (fMRI)Experimental Treatment1 Intervention

The interventions for this study are non-invasive. For patients, routine pre-operative MRI that includes task based fMRI and perfusion data acquisition will be performed on a 3T scanner. Patients who participate in this study, will have approximately 5 minutes added to their scan time for the below described breath holding fMRI (BH fMRI) paradigm, which will be done for research purposes. For healthy volunteers, participation will involve having a high resolution anatomical MRI done with the same paradigms which patients will have, listed below. the total scanner time will be approximately 25 minutes, and the scan will not be billed to the healthy volunteer.

0 / 5Eligibility criteria met

Find a Location

Who is running the clinical trial?

Memorial Sloan Kettering Cancer CenterLead Sponsor

1,934 Previous Clinical Trials

588,777 Total Patients Enrolled

Weill Medical College of Cornell UniversityOTHER

1,054 Previous Clinical Trials

1,316,519 Total Patients Enrolled

Andrei Holodny, MDPrincipal InvestigatorMemorial Sloan Kettering Cancer Center

3 Previous Clinical Trials

79 Total Patients Enrolled

Media Library

Brain Tumor Research Study Groups: Functional Magnetic Resonance Imaging (fMRI)

fMRI Paradigms 2023 Treatment Timeline for Medical Study. Trial Name: NCT03604302 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does this research endeavor admit individuals seventy years old or older?

"This research project is open to adults between the ages of 18 and 80; however, there are distinct studies for those below 18 (82) and above 65 years old (351)."

Answered by AI

Are there any available vacancies to participate in this research?

"Records on clinicaltrials.gov indicate that this experiment is not registering participants at present, despite its initial posting being dated August 1st 2018 and the last amendment occurring July 7th 2022. Thankfully, there are 408 other trials actively looking for volunteers currently."

Answered by AI

Who are the ideal candidates for enrollment in this investigation?

"This clinical trial is looking to enrol 33 individuals, aged 18-80, with neoplasms in the brain. To be eligible for participation they must meet certain criteria such as being able to complete language paradigms while inside a scanner and have a negative pregnancy test (for women of childbearing potential). Furthermore, participants should either have been diagnosed or suspected of having primary glial neoplasm, meningioma and metastasis according to postoperative histology or imaging respectively. Lastly volunteers need to demonstrate good health."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Evaluation of Preoperative Functional Magnetic Resonance Imaging (fMRI) in Patients With Brain Tumors

2018. "Evaluation of Preoperative Functional Magnetic Resonance Imaging (fMRI) in Patients With Brain Tumors". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03604302.

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