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Behavioral Intervention
Aerobic Exercise for Aging and Alzheimer's (AEROBIC Trial)
N/A
Recruiting
Research Sponsored by University of Kansas Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Post-menopausal
Diagnosis of either Nondemented (CDR 0) or Probable AD (CDR 0.5 or 1 only)
Timeline
Screening 3 weeks
Treatment Varies
Follow Up resting vs acute exercise bout: ~1 month
Awards & highlights
AEROBIC Trial Summary
This trial will examine how exercise affects brain glucose metabolism in aging and Alzheimer's Disease, as well as how it affects cognition and lactate metabolism.
Who is the study for?
This trial is for post-menopausal individuals aged 60 or older, with stable medication use. It's open to those without dementia (CDR 0) or with early Alzheimer's Disease (CDR 0.5 or 1). People can't join if they have type 1 diabetes, recent heart disease, significant chronic diseases, MRI incompatibility, other neurological disorders affecting cognition, severe depression, certain cognitive impairments due to B12/thyroid issues, or are on psychoactive drugs.Check my eligibility
What is being tested?
The study focuses on how a single session of aerobic exercise affects brain glucose and lactate metabolism in aging adults and those with Alzheimer’s Disease. It will also explore the relationship between exercise intensity and cognitive function.See study design
What are the potential side effects?
Since this trial involves acute aerobic exercise as an intervention rather than medication, side effects may include typical responses to physical activity such as increased heart rate, shortness of breath during exertion, muscle soreness after exercise and fatigue.
AEROBIC Trial Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I have gone through menopause.
Select...
I am diagnosed with early-stage Alzheimer's or have no dementia.
Select...
I am 60 years old or older.
AEROBIC Trial Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ resting vs acute exercise bout: ~1 month
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~resting vs acute exercise bout: ~1 month
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Positron-Emission Tomography
Secondary outcome measures
Brain-derived neurotrophic factor (BDNF) Change
Lactate Area Under the Curve
AEROBIC Trial Design
2Treatment groups
Experimental Treatment
Group I: Moderate Intensity Aerobic ExerciseExperimental Treatment1 Intervention
45-55% of heart rat reserve (HHR) Low range = ((Max HR from Visit 1) - Resting HR ) * 0.45 + Resting HR High range = ((Max HR from Visit 1) - Resting HR) * 0.55 + Resting HR
Group II: High Intensity Aerobic ExerciseExperimental Treatment1 Intervention
65-75% of heart rat reserve (HHR) Low range = ((Max HR from Visit 1) - Resting HR ) * 0.65 + Resting HR High range = ((Max HR from Visit 1) - Resting HR) * 0.75 + Resting HR
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Aerobic Exercise
2013
Completed Early Phase 1
~1310
Find a Location
Who is running the clinical trial?
University of Kansas Medical CenterLead Sponsor
462 Previous Clinical Trials
169,147 Total Patients Enrolled
4 Trials studying Healthy Aging
425 Patients Enrolled for Healthy Aging
National Institute on Aging (NIA)NIH
1,671 Previous Clinical Trials
28,017,003 Total Patients Enrolled
13 Trials studying Healthy Aging
1,494 Patients Enrolled for Healthy Aging
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- My medication doses have been stable for over a month.I have gone through menopause.I have a chronic condition like heart disease, thyroid issues, cancer, HIV, or AIDS.My medication doses have been stable for over a month.I am diagnosed with early-stage Alzheimer's or have no dementia.I do not have severe depression, vitamin B12, syphilis, thyroid issues, or use psychoactive drugs that could affect my thinking. I also do not have major hearing or vision problems.I do not have any neurological disorders like Parkinson's or a history of stroke.I have not had a heart attack or heart disease in the last 2 years.You cannot have or finish an MRI scan.I am unable to give consent by myself.I have been diagnosed with Type 1 Diabetes.I am 60 years old or older.
Research Study Groups:
This trial has the following groups:- Group 1: Moderate Intensity Aerobic Exercise
- Group 2: High Intensity Aerobic Exercise
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Healthy Aging Patient Testimony for trial: Trial Name: NCT04299308 — N/A
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Are there currently any vacancies available for the clinical trial?
"As evidenced on clinicaltrials.gov, the research team is actively seeking participants for this trial initially posted 8/28/2020 and ammenden 11/1/2022."
Answered by AI
How many individuals are taking part in this experiment?
"Confirmative. According to the clinicaltrials.gov, this medical study was listed on August 28th 2020 and has been actively seeking patients since then. The trial is looking for 60 participants across a single site."
Answered by AI
Who else is applying?
What state do they live in?
Missouri
Kansas
What site did they apply to?
Univeristy of Kansas Medical Center
What portion of applicants met pre-screening criteria?
Did not meet criteria
Met criteria
How many prior treatments have patients received?
1
0
What questions have other patients asked about this trial?
When will this start? is their any payment? When will this start? Where will the activity be held?
PatientReceived 1 prior treatment
I’d like to know time commitment. Number of visits. Compensation?
PatientReceived no prior treatments
Why did patients apply to this trial?
Interested in healthy aging.. I want to stay healthy in mind body and soul.
PatientReceived 1 prior treatment
Am interested in how exercise will help me to continue to be healthy. I am interested in the study, treatment, and prevention of dementia and Alzheimer’s.
PatientReceived 2+ prior treatments
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