Peer Support for Alcoholic Liver Disease

(THRIVES Trial)

ME
PC
Overseen ByPo-Hung Chen, MD, PhD
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: Johns Hopkins University
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

Liver transplant (LT) recipients with a history of alcohol-related liver disease (ALD) may encounter various psychosocial and medical challenges during post-LT recovery, even beyond the initial post-transplant period. Effective and sustainable interventions will be crucial for improving patient outcomes. This clinical trial will examine the impact of peer support specialists (PSS) on the recovery experience of individuals who received LT for ALD. The trial seeks to answer two main questions:

* Are LT recipients who work with PSS less likely to resume alcohol use or tend to drink less overall?

* Do LT recipients who work with PSS engage more with recommended medical care and have better overall survival?

Who Is on the Research Team?

PC

Po-Hung Chen, MD, PhD

Principal Investigator

Johns Hopkins University

Are You a Good Fit for This Trial?

This trial is for individuals who have had a liver transplant due to alcohol-related liver disease. It aims to help them with recovery by providing peer support. Participants should not be currently involved in any other similar intervention studies.

Inclusion Criteria

English speakers
Has 1 to 3 years of continuous alcohol abstinence at the time of trial entry
I had a liver transplant due to liver disease from alcohol.

Exclusion Criteria

I received a liver transplant and did not have alcohol-related liver disease.
I am unable to understand or sign the consent form.
Active participation in a separate intervention trial for alcohol use disorder

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Peer Support Intervention

Participants receive support from Peer Support Specialists (PSS) who have lived experiences with ALD/LT. PSS provide brief counseling, active listening, and meet with participants at regular intervals.

1 year

Follow-up

Participants are monitored for alcohol consumption, engagement in medical care, and overall survival.

1 year

What Are the Treatments Tested in This Trial?

Interventions

  • Peer Support

Trial Overview

The study is testing whether having a Peer Support Specialist (PSS) can reduce the chances of patients returning to alcohol use and improve their engagement with medical care post-liver transplant.

How Is the Trial Designed?

1

Treatment groups

Experimental Treatment

Group I: Peer Support Specialist (PSS)Experimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Johns Hopkins University

Lead Sponsor

Trials
2,366
Recruited
15,160,000+

National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Collaborator

Trials
865
Recruited
1,091,000+