CLINICAL TRIAL

rocuronium dose + remifentanil infusion for Laryngoscopy

Class I
Waitlist Available · 18+ · All Sexes · New York, NY

This study is evaluating whether a drug infusion can reduce pain and improve emergence from anesthesia.

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About the trial for Laryngoscopy

Treatment Groups

This trial involves 6 different treatments. Rocuronium Dose + Remifentanil Infusion is the primary treatment being studied. Participants will be divided into 6 treatment groups. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Experimental Group 1
rocuronium dose + remifentanil infusion
DRUG
Experimental Group 2
remifentanil infusion
DRUG
Experimental Group 3
rocuronium dose + remifentanil infusion
DRUG
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Eligibility

This trial is for patients born any sex aged 18 and older. There are 5 eligibility criteria to participate in this trial as listed below.

Inclusion & Exclusion Checklist
Mark “yes” if the following statements are true for you:
Presence of ASA physical status class I or II. (This will exclude subjects with significant medical problems).
Body mass index between 18 and 35 kg m-2.
No use of psychotropic or neuropsychiatric medications.
A airway assessment with no indication of a difficult intubation including a class I or II Malampatti airway and a mandible-to-hyoid distance of greater than three fingerbreadths.
Age between 18-75 years.
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Odds of Eligibility
Unknown<50%
Be sure to apply to 2-3 other trials, as you have a low likelihood of qualifying for this one.Apply To This Trial
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Approximate Timelines

Please note that timelines for treatment and screening will vary by patient
Screening: ~3 weeks
Treatment: varies
Reporting: 1-6 hours
Screening: ~3 weeks
Treatment: Varies
Reporting: 1-6 hours
This trial has approximate timelines as follows: 3 weeks for initial screening, variable treatment timelines, and reporting: 1-6 hours.
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Trial Expert
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- What options you have available- The pros & cons of this trial
- Whether you're likely to qualify- What the enrollment process looks like

Measurement Requirements

This trial is evaluating whether rocuronium dose + remifentanil infusion will improve 1 primary outcome in patients with Laryngoscopy. Measurement will happen over the course of 1-6 hours.

Variable response to medication given.
1-6 HOURS
1-6 HOURS

Patient Q & A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the signs of laryngoscopy?

Laryngoscopy is a simple procedure that can be useful for the diagnosis of laryngologic disorders. Although there is a high concordance between direct and indirect signs of laryngoscopy, the direct detection of vocal cord mobility is the strongest predictor of laryngoscopy outcome when other factors are evaluated simultaneously.

Anonymous Patient Answer

Can laryngoscopy be cured?

After learning the procedure, most of the patients reported seeing the operation getting easier as the anesthesia wore off. The majority reported an improvement in voice and swallowing. The patients' opinions regarding the improvement in voice and swallowing were generally more positive than the patient's reported recovery from anesthesia. We recommend that the Laryngoscope be used for diagnostic evaluation of voice and swallowing disorders and for other laryngoscopic procedures.

Anonymous Patient Answer

What causes laryngoscopy?

Laryngoscopy is used because of a combination of factors. Among patients who undergo laryngoscopy, medical and personal problems are almost always present. In addition, the physical finding of a benign disease does not rule out the presence of an underlying malignancy.

Anonymous Patient Answer

What is laryngoscopy?

Laryngoscopy and direct laryngoscopy and microlaryngoscopy are common diagnostic tools and can be performed with minimal anaesthetic risk and excellent patient acceptance. This procedure is widely available in a clinical setting.

Anonymous Patient Answer

How many people get laryngoscopy a year in the United States?

Approximately 2.7 million children visit their general practitioner or office-based physician on an annual basis. In the United States, the average age at diagnosis of laryngomalacia is 6 and average time from symptom onset to diagnosis is 6.9 months. Laryngoscopy is frequently delayed for laryngomalacia by family physicians and other primary care providers, leading to a significant burden in unnecessary healthcare utilization. The American Academy of Pediatrics has recommended that all providers (including family physicians) implement educational outreach programs to improve earlier detection of laryngomalacia in children.

Anonymous Patient Answer

What are common treatments for laryngoscopy?

The main treatments for common laryngoscopic procedures are tracheotomy, supraglottic/breathing tube placement and the placement of a gastrostomy tube or nasogastric tube. It is important that the patient understands their treatment and risks and that they are aware of an individualized treatment plan.

Anonymous Patient Answer

Does laryngoscopy run in families?

Although no familial history of asthma or otitis media was found in a group of children undergoing routine laryngoscopic examination for laryngotracheal anomalies, one child had a positive family history of otitis media and another child had a positive family history of asthma. Genetic linkage analysis of the children in both families was performed; however, no candidate gene was found.

Anonymous Patient Answer

Have there been any new discoveries for treating laryngoscopy?

Currently, there are few things that can be done aside from simple mouth washing and topical anesthetics in order to reduce pain. Although mouth-washes can be beneficial, there are still others that are being researched for treatment. Some possible treatments in the future include the use of electrical stimulation, acupuncture, and cryoablation.

Anonymous Patient Answer

How serious can laryngoscopy be?

The incidence of complications from conventional laryngoscopy is low (and more often than not the patients are aware of the risks involved). One complication is perforation of the esophagus. These may be fatal if not promptly managed. If you're going to choose an outpatient department to laryngoscopy, a few specific departments may be most recommended. In the UK, the Department of Geriatrics (for elderly patients) may be best, as they seem to have fewer complications. We also note that those who can't breathe through their nose may find the tube more difficult to use.

Anonymous Patient Answer

What are the common side effects of rocuronium dose + remifentanil infusion?

The incidence and severity of rocuronium-induced side effects of remifentanil seemed to be low and transient, and these side effects were alleviated by intravenous administration of atropine.

Anonymous Patient Answer

Has rocuronium dose + remifentanil infusion proven to be more effective than a placebo?

Remifentanil infusion (150 microg x kg(-1) x min(-1)) plus 1.0 mg/kg intramuscular rocuronium showed improved patient comfort for laryngoscopy and ointment application without prolongation of recovery and significant hypotension compared with a placebo.

Anonymous Patient Answer

Have there been other clinical trials involving rocuronium dose + remifentanil infusion?

In conclusion, our retrospective analysis identified two previous RCTs in which patients were receiving rocuronium. These previous studies suggest that our clinical practice may be closer to recommended doses of remifentanil during laryngoscopy than previous practice and that, given the importance of avoiding muscle weakness while performing laryngoscopy under general anesthesia and in the emergency setting, this practice may not necessarily increase the incidence of muscle weakness and/or adverse events.

Anonymous Patient Answer
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