Ketorolac for Pain Management
(KETOROLAC-ICU Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
Opiates are commonly used to control pain in critically ill patients in the ICU. However, increased rates of opiate use in hospital may lead to increased prescription-based opiate dependence after leaving the ICU. This may contribute to the ongoing opiate epidemic across the world. Other medications that can reduce pain, like non-steroidal anti-inflammatory drugs (NSAIDs), are being studied in critically ill patients. These drugs block the enzyme, cyclooxygenases (COX), which causes inflammation in the body. Blocking these enzymes can decrease pain, fever, and inflammation. Traditionally, NSAIDs are not commonly used in critically ill patients due to the perceived risk of gastrointestinal (GI) bleeding and acute kidney injury (AKI). However, many critically ill patients are already receiving medications and treatments to prevent GI bleeding and AKI and are closely monitored so these medications may be useful in reducing pain for these patients.The purpose of this study is to see whether NSAIDs can be used safely in critically ill patients to reduce the dose of opiates required for pain control. This is a pilot study or a feasibility study, which is not expected to answer the question definitively. Its main purpose is to determine if NSAIDs could reduce the use of opiates in critically ill patients while in the ICU. The data collected in this study may be used in a larger study in the future.
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but you cannot participate if you are currently using certain medications like ACE inhibitors, ARBs, or NSAIDs for other reasons. It's best to discuss your specific medications with the trial team.
Is ketorolac generally safe for pain management in humans?
Ketorolac is generally safe for pain management, but it can cause side effects like stomach bleeding, kidney problems, and allergic reactions, especially in high doses or long-term use. It's important to follow dosage guidelines and avoid use in people with certain conditions like asthma or a history of stomach issues.12345
How is the drug ketorolac unique for pain management?
Ketorolac is unique because it provides strong pain relief similar to opioids but without affecting the central nervous system, making it a safer option with fewer regulations. It works by blocking the production of prostaglandins, which are chemicals in the body that cause pain and inflammation.678910
What data supports the effectiveness of the drug Ketorolac for pain management?
Research shows that Ketorolac is effective in managing moderate to severe pain after minor or intermediate surgeries, helping patients recover faster with fewer side effects. It also works well when combined with opioids, reducing the need for higher doses of opioids, which can be beneficial in managing pain after major surgeries.1112131415
Who Is on the Research Team?
Vincent I Lau, MD MSc
Principal Investigator
University of Alberta
Are You a Good Fit for This Trial?
This trial is for critically ill ICU patients who need pain management. It's exploring if lower doses of Ketorolac, an NSAID, can reduce the need for opiates. Patients with risks of GI bleeding or kidney injury are typically excluded but may be monitored closely in this study.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive either ketorolac or placebo along with standard care in the ICU
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Ketorolac
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Alberta
Lead Sponsor