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Trametinib for Epithelioid Hemangioendothelioma
Study Summary
This trial studies how well trametinib works in treating patients with metastatic, locally advanced, or unresectable epithelioid hemangioendothelioma.
- Epithelioid Hemangioendothelioma
Timeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Side effects data
From 2021 Phase 2 trial • 206 Patients • NCT02034110Trial Design
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Who is running the clinical trial?
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- You have had another type of cancer in the past.You have a device called an intra-cardiac defibrillator implanted in your heart.You cannot take any herbal supplements during the study, including popular ones like St. John's wort, ginkgo biloba, or ginseng.You have a history of or are currently at risk for a vision problem called retinal vein occlusion (RVO).Your cancer has either gotten worse according to a specific measurement method, or you are experiencing significant pain that needs to be managed with strong pain medications.You are expected to live for at least 6 more months.You have cancer that has spread to your brain or spinal cord and is causing symptoms.You cannot be receiving any other cancer treatments while participating in this study, except for megestrol (Megace) if it is being used to increase your appetite.You have a history of serious heart rhythm problems that are not currently under control, except if you have had atrial fibrillation for more than 30 days and it is being managed well.You have experienced a heart attack, unstable angina, had a coronary angioplasty or stenting within the last 6 months.You have cancer that has spread to your heart.You have already received treatment with a medication called a MEK inhibitor before.You can participate in the study whether you have been treated for epithelioid hemangioendothelioma (EHE) before or not. The number of previous treatments you have had does not matter.You have had a lung disease in the past that required extra oxygen or treatment with strong medications.You have experienced allergic reactions or adverse effects to medications similar to trametinib or to the substances used to make it.You have a history or signs of heart problems, such as issues with your heart or blood vessels.You have high blood pressure that cannot be controlled with medication.
- Group 1: Treatment (trametinib)
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Can you provide information on any prior trials that have utilized Trametinib?
"Trametinib was initial trialed at the University of Chicago Medical Centre in 2012, and since then 247 studies have been completed. Currently, 92 trials are actively recruiting participants; with a large concentration of these occurring within Omaha, Nebraska."
Might Trametinib pose a risk to human health?
"Trametinib's safety has been partially supported by data in Phase 2 trials, giving it a score of 2 on our internal scale. However, there is currently no evidence supporting its efficacy."
How many healthcare facilities have implemented this research experiment?
"Within the United States, patients are being recruited for this trial at 36 distinct sites. This includes University of Nebraska Medical Center in Omaha, University of Kansas Clinical Research Center in Fairway, and Montefiore Medical Center - Moses Campus in Bronx among other locations."
How many participants have enrolled in this clinical investigation?
"This trial is no longer open for recruitment. According to the timeline posted on clinicaltrials.gov, it was first listed in April 19th 2017 and last updated on October 19th 2022. At present time, there are 12 trials searching for patients with hemangioendothelioma and 92 studies utilizing Trametinib actively recruiting around the world."
Is this research actively seeking new participants?
"Unfortunately, according to clinicaltrials.gov records, this medical study is not currently seeking participants; the post was initially published on April 19th 2017 and last updated on October 19th 2022. However, there are presently 104 other trials that require enrolment of volunteers."
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