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Procedure

Nerve Block + Physiotherapy for Complex Regional Pain Syndrome

N/A

Waitlist Available

Research Sponsored by Tracy Cupido

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 2 years

Awards & highlights

Study Summary

This trial will assess a novel treatment protocol for Complex Regional Pain Syndrome (CRPS), a debilitating condition affecting 1 of 5 Canadians, to determine its efficacy and reduce healthcare cost.

Who is the study for?

This trial is for adults over 18 with Complex Regional Pain Syndrome (CRPS) in the upper extremity who can consent to treatment. It's not suitable for those allergic to local anesthetics or chlorhexidine, have an infection at the injection site, had regional anesthesia for CRPS within 6 months, cannot tolerate anesthesia or physiotherapy, have another pain condition affecting the same limb, or cannot consent.Check my eligibility

What is being tested?

The study is testing if a single-shot axillary brachial plexus block combined with physiotherapy is more effective than just physiotherapy alone in treating CRPS. The goal is to see if this new approach improves pain and function better than current treatments.See study design

What are the potential side effects?

Potential side effects may include reactions at the injection site such as pain or infection, allergic reactions to the anesthetic used during nerve block procedures, and typical risks associated with physiotherapy like muscle soreness.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 2 years

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~2 years

This trial's timeline: 3 weeks for screening, Varies for treatment, and 2 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Feasibility Assessment

Secondary outcome measures

Cost

Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: Axillary Brachial Plexus Block plus PhysiotherapyExperimental Treatment1 Intervention

Participants who are randomized to the experimental group (EXP arm) will receive a single-shot axillary-approach brachial plexus block with 1.5mg/kg (up to 50mg total) bupivacaine 0.25% at the Kingston Health Sciences Centre Chronic Pain Clinic (KHSC-CPC). Prior to treatment, a blinded third party will perform a baseline physical exam. Under the brachial plexus block, the physiotherapist will provide standard of care, including manual therapy. The patient will then complete a 6-week physiotherapy program, including GMI. Following the 6 week program, a blind observer will repeat the physical exam.

Group II: Physiotherapy aloneActive Control1 Intervention

Participants who are randomized to not receive a block (CON arm) will also have a baseline physical exam performed by a blinded third party. Following baseline data collection, the physiotherapist will provide standard of care, including manual therapy. They will then complete a 6-week home exercise program, including GMI. Following the 6 week program, a blinded observer will repeat the physical exam.

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Tracy CupidoLead Sponsor

Queen's UniversityLead Sponsor

365 Previous Clinical Trials

120,357 Total Patients Enrolled

Media Library

Brachial Plexus Block (Procedure) Clinical Trial Eligibility Overview. Trial Name: NCT05589259 — N/A

Complex Regional Pain Syndrome Research Study Groups: Axillary Brachial Plexus Block plus Physiotherapy, Physiotherapy alone

Complex Regional Pain Syndrome Clinical Trial 2023: Brachial Plexus Block Highlights & Side Effects. Trial Name: NCT05589259 — N/A

Brachial Plexus Block (Procedure) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05589259 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are individuals older than 55 years eligible to be a part of the research?

"This clinical trial has a minimum age of 18 and a maximum age of 110, as specified by the eligibility criteria."

Answered by AI

Is the protocol for this study currently accepting participants?

"This research endeavour, which was initially launched on September 1st 2023 and last modified August 31st 2023, is not currently looking for participants. However, there are 1428 other medical studies actively enrolling patients right now."

Answered by AI

What characteristics are necessary to qualify for this research project?

"This research aims to recruit 60 individuals between the ages of 18 and 110 who have been diagnosed with complex regional pain syndrome. In order for them to be eligible, they must meet these further criteria: over 18 years old, match the Budapest description of CRPS in their upper limbs, and give consenting agreement for treatment."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Feasibility Study of Combined Peripheral Nerve Block and Physiotherapy for CRPS

Tracy Cupido 2025. "Feasibility Study of Combined Peripheral Nerve Block and Physiotherapy for CRPS". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05589259.

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