elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide or other medically-appropriate FDA-approved antiretroviral therapy for Infections
This study is evaluating whether starting antiretroviral therapy (ART) early in those recently or acutely infected with HIV-1 affects the amount of HIV-1 in blood and how well the body fights the HIV-1 infection.
See full descriptionAbout the trial for Infections
Treatment Groups
This trial involves 5 different treatments. Elvitegravir/cobicistat/emtricitabine/tenofovir Alafenamide Or Other Medically-appropriate FDA-approved Antiretroviral Therapy is the primary treatment being studied. Participants will be divided into 5 treatment groups. There is no placebo group. The treatments being tested are in Phase 2 and have already been tested with other people.
Eligibility
This trial is for patients born any sex aged 18 and older. There are 10 eligibility criteria to participate in this trial as listed below.
Approximate Timelines
Measurement Requirements
This trial is evaluating whether elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide or other medically-appropriate FDA-approved antiretroviral therapy will improve 2 primary outcomes and 6 secondary outcomes in patients with Infections. Measurement will happen over the course of At week 0.
Patient Q & A Section
What are the signs of infections?
There are many possible signs of infections. Specific areas of the body are more likely to be infected with a particular organism. The most common sign of an infection is pain.
How many people get infections a year in the United States?
In 2015, the rate of infections among adults was 13 per 1,000 person years; among children and adolescents, it was 5 per 1,000 person years. While infection is the second most common cause of death among all infectious diseases, it is the fourth most common cause of death among infectious disease outbreaks.
What is infections?
Some infections, for example pneumonia, myocarditis, meningitis and sepsis, can be related with many neurological complications. In patients with central nervous system disease, the infections are the most common causes of hospitalizations or deaths.
What are common treatments for infections?
What treatments are used for infections? A complete list is listed below. In some cases, the list was incomplete. As an example, the list of common treatments for infections excludes some anticoagulants, such as warfarin.\n- "Aerobic bacterial (Gram-positive)\n- "Gram-positive bacteriophage (Bacteriophage)\n- "Anaerobic bacterial (Gram-positive) (L. fermentans)\n- "Anaerobic bacterial (L. acidophilus)\n- Anaerobic bacterial (L.
What causes infections?
The types of infections, their severity and probability of developing, are different for infections in adults compared to infants. Different types of infection have their own causes, and are also associated with different risk factors.\n
Can infections be cured?
A few infections, including HIV and syphilis, can be successfully eradicated or overcome with the use of drugs and, in some cases, other health interventions. However, in a globalized world, many other diseases and infections are becoming increasingly problematic because of emerging drug resistance and a limited number of available medications and health resources. These problems can be resolved by eliminating the underlying infection or disease, but the eradication of a persistent viral or other bacterial infection or disease will be much more difficult. Thus, the goals of global public health can be achieved either by treating existing infections or diseases, or by reducing the incidence of new infections by improving public health practices, education, and improved facilities for care, delivery, and diagnosis.
What is the primary cause of infections?
As our study shows, the main cause of upper infectious episodes in a German university hospital is still not completely known. Despite the fact that patient infection prophylaxis is performed routinely since the early 1980s, we could not identify the respective risk groups for specific microorganisms. Patients with chronic illnesses, such as cystic fibrosis, and patients with previous surgeries (e.g., [biliary duct, bone graft]?) are more prone to acquire infections. Results from a recent clinical trial warrant the implementation of an individual patient risk stratification for infections in medical and surgical intensive care units. The prevention of secondary infections in these patients would be of particular interest because they are responsible for a high turnover rate of surgical intensive care units.
Is elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide or other medically-appropriate fda-approved antiretroviral therapy safe for people?
The use of elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide, a once-daily regimen approved by the fda for antiretroviral therapy, in a population with significant comorbidities, was reported to be well tolerated, with no appreciable risk of neuropathies, nephrolithiasis, or hyperlipidemia compared with other antiretroviral regimens that are commonly used in clinical practice.
How does elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide or other medically-appropriate fda-approved antiretroviral therapy work?
The initial results indicate that a "tenofovir-elvitegravir-cobicistat" regimen is associated with good response. However, caution is warranted in its use, as there is still a need to confirm non-nucleoside protease inhibitor resistance profiles.
What is elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide or other medically-appropriate fda-approved antiretroviral therapy?
Elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide seems an effective regimen for treatment-naive HIV-infected patients in terms of viral suppression and the development of resistance in the absence of ARTs. Furthermore, the most frequent adverse events observed in this analysis were expected.
What are the common side effects of elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide or other medically-appropriate fda-approved antiretroviral therapy?
Treatment with FDC-based antiretroviral regimens for the treatment of HIV-1 infection is well tolerated. In clinical trials, the most common side effects of FDC-based therapy were diarrhea, nausea, headache, and abdominal pain. FDC-based treatment may minimize or eliminate the need for antimanic agents and could reduce the use of antihistamines. There have been no reports in the medical literature of serious adverse effects, and the possibility of drug interactions is not expected.
What does elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide or other medically-appropriate fda-approved antiretroviral therapy usually treat?
There is a need for improved treatment options that optimize suppression of HIV replication to prevent opportunistic infections and improve survival in the setting of advanced HIV disease or HIV/ART drug resistance.