This trial is testing different doses of estrogen to see which is most effective in reducing the risk of heart disease in women who have had their ovaries removed before age 46.
- Cardiovascular Risk Reduction
2 Primary · 4 Secondary · Reporting Duration: Baseline, 6 months, and 12 months
3 Treatment Groups
Timed Control Group
1 of 3
Standard replacement therapy regimen
1 of 3
Titrated replacement therapy regimen
1 of 3
60 Total Participants · 3 Treatment Groups
Primary Treatment: Standard replacement therapy regimen · No Placebo Group · Phase 2
Who is running the clinical trial?
Age 21 - 45 · Female Participants · 4 Total Inclusion CriteriaMark “Yes” if the following statements are true for you:
Frequently Asked Questions
What overarching goals is this clinical trial attempting to achieve?
"The primary evaluation of this clinical trial, which occurs at Baseline, 6 months, and 12 months is to assess Change in Endothelial function. Additional objectives include gauging Change in Arterial tonometry (Arterial stiffness via high-fidelity pressure waveforms), assessing the index of baroreflex sensitivity (Colder pressor test immersing hand up to wrist in ice water) and measuring whole body and regional fat/fat-free mass (via Dual energy x-ray absorptiometry scans)." - Anonymous Online Contributor
How many participants are being invited to join this experiment?
"Affirmative. Information hosted on clinicaltrials.gov confirms that this medical research, which was initially posted on March 15th 2019, is actively recruiting individuals for participation. Sixty volunteers need to be enlisted from 1 trial location." - Anonymous Online Contributor
Are there any openings for participants in this research study at present?
"Indeed, clinicaltrials.gov reveals that this research is actively seeking participants as of October 17th 2022. Initially published on March 15th 2019, the trial requires 60 volunteers from a single medical facility." - Anonymous Online Contributor
Is the age eligibility for this trial limited to those under 30?
"To be included in this research, individuals must range between 21 and 45 years old. There are 32 studies for those under 18 and 389 trials catered towards seniors above 65." - Anonymous Online Contributor
Does the FDA currently recognize a Standard replacement therapy regimen?
"Taking into account the lack of prior clinical data demonstrating efficacy, Standard replacement therapy regimen has been assigned a rating of 2 on our safety scale." - Anonymous Online Contributor
For which clinical indications is the Standard replacement therapy regimen usually prescribed?
"Replacement therapy is the go-to course of action for those with amenorrhea, as well as individuals experiencing hypoestrogenism, vasomotor symptoms related to menopause and breast ailments." - Anonymous Online Contributor
Who has the potential to qualify for this medical research?
"Participants between the ages of 21 and 45 who are looking to reduce their cardiovascular risk can expect to be recruited for this trial. Approximately 60 people will be chosen in total." - Anonymous Online Contributor