Perflutren lipid microsphere for Kidney Neoplasms

Phase-Based Progress Estimates
1
Effectiveness
2
Safety
University of North Carolina at Chapel Hill, Chapel Hill, NC
Kidney Neoplasms+2 More
Perflutren lipid microsphere - Drug
Eligibility
18+
All Sexes
What conditions do you have?
Select

Study Summary

This study is evaluating whether contrast-enhanced ultrasound can detect abnormal features of kidney lesions in patients with suspected kidney cancer with the same accuracy as conventional ultrasound and contrast-enhanced magnetic resonance imaging

See full description

Eligible Conditions

  • Kidney Neoplasms
  • Renal Cancers

Treatment Effectiveness

Study Objectives

This trial is evaluating whether Perflutren lipid microsphere will improve 1 primary outcome and 2 secondary outcomes in patients with Kidney Neoplasms. Measurement will happen over the course of (Baseline).

(Baseline)
Comparing diagnostic accuracy of F-R infusion imaging technique to low MI bolus imaging technique
Predicting kidney mass diagnosis using 3D CEUS generated metrics
Predicting kidney mass stage using 3D CEUS-generated metrics

Trial Safety

Safety Progress

2 of 3
This is further along than 68% of similar trials

Trial Design

1 Treatment Group

Perflutren Lipid Microsphere or Lumason
1 of 1
Experimental Treatment

This trial requires 25 total participants across 1 different treatment group

This trial involves a single treatment. Perflutren Lipid Microsphere is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase 2 and have already been tested with other people.

Perflutren Lipid Microsphere or LumasonPatients with suspected kidney cancer and planned surgery will be imaged using contrast-enhanced ultrasound with either perflutren or Lumason.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Sulfur hexafluoride
FDA approved
Perflutren
FDA approved

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: (baseline)
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly (baseline) for reporting.

Closest Location

University of North Carolina at Chapel Hill - Chapel Hill, NC

Eligibility Criteria

This trial is for patients born any sex aged 18 and older. There are 4 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
A suspected diagnosis of kidney cancer with a solid or partially solid lesion and planned surgical nephrectomy within 3 months before surgery
Able to provide informed consent
Willing to comply with protocol requirements
At least 18 years of age

Patient Q&A Section

What are the signs of kidney neoplasms?

"All patients will have an increased risk of developing cancer in their kidney. Nephrectomy is a procedure that may be an option to help keep a kidney neoplasm from growing. Another option is a watch-and-wait policy as long as a person does not have a life-threatening or debilitating symptom. Kidney transplantation may be an option for those who will not tolerate a watch-and-wait policy. The signs of kidney neoplasms in children do not differ dramatically from the signs in adults." - Anonymous Online Contributor

Unverified Answer

Can kidney neoplasms be cured?

"The cure of a renal tumor is a possibility if the tumor is surgically treated after neoadjuvant chemotherapy. However, cure rates are low and relapse may occur even if the main tumor is removed. Therefore, cure of kidney tumors is not recommended in the present clinical situation." - Anonymous Online Contributor

Unverified Answer

What are common treatments for kidney neoplasms?

"These cases are most commonly treated by radical nephrectomy or nephron sparing surgery. The patient will undergo periodic scans for the detection of recurrent disease." - Anonymous Online Contributor

Unverified Answer

How many people get kidney neoplasms a year in the United States?

"There are more than 120,000 new cases of kidney cancer each year in the United States. Most tumors occur by the age of 55 and only 5% of them are diagnosed within the 5-year interval after the detection of a kidney mass." - Anonymous Online Contributor

Unverified Answer

What is kidney neoplasms?

"The most common and well-known kidney neoplasm is renal cell cancer, which is one of the most lethal forms of cancer. An estimated 30,000 new cases of kidney cancer will be diagnosed in the USA in 2011, accounting for 1.4% of all newly diagnosed cancers. It is a disease of the older patient population with an annual prevalence of 8.8/100,000." - Anonymous Online Contributor

Unverified Answer

What causes kidney neoplasms?

"Individuals infected with parasites and those exposed to pesticides or solvents have a greater risk of kidney neoplasms. The link between infections and kidney neoplasms seems to be related to the immunodeficiency of the infected person and inflammation of the kidney tissue." - Anonymous Online Contributor

Unverified Answer

Does perflutren lipid microsphere improve quality of life for those with kidney neoplasms?

"This meta-analysis is the first meta-analysis to evaluate PUF versus PL MPS in the treatment of kidney cancer. PUF-LV did not demonstrate differences in efficacy in terms of QOL outcomes relative to PL MPS. Future studies should systematically evaluate the role of PL MPS in improving patient QOL." - Anonymous Online Contributor

Unverified Answer

How does perflutren lipid microsphere work?

"Findings from a recent study from clinical trials suggest that LDL-bound perflubron is highly specific for tumour imaging, and could potentially be used as a diagnostic parameter in patients with early-stage carcinomas or borderline lesions." - Anonymous Online Contributor

Unverified Answer

Has perflutren lipid microsphere proven to be more effective than a placebo?

"In a recent study, findings of this study do not support the hypothesis that treatment with PFM compares to placebo in patients with advanced carcinoma of the pleural cavity." - Anonymous Online Contributor

Unverified Answer

What are the chances of developing kidney neoplasms?

"According to the results of this study, the odds of having kidney neoplasms are low, with no particular risk factors associated with the disease development." - Anonymous Online Contributor

Unverified Answer

What is the survival rate for kidney neoplasms?

"About half of kidney tumors are RCCs and more than half of the remaining tumors are renal cell carcinomas that are metastatic at time of diagnosis (i.e., they disseminated from the kidney). The prognosis of RCC is generally worse when it is not localized or diagnosed at an early stage. The prognosis in tumors of the other type, metastatic at the time of diagnosis, is significantly worse regardless of the nature of treatment, such as surgery." - Anonymous Online Contributor

Unverified Answer

How serious can kidney neoplasms be?

"Although kidney neoplasms rarely lead to death before diagnosis, they may cause severe pain and compromise physical and mental well-being after diagnosis. Kidney neoplasms cause significant suffering for the patients before diagnosis. Furthermore, a high prevalence of renal tumors in patients with a previous history of kidney neoplasms suggests that neoplasms may be underdiagnosed." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
See if you qualify for this trial
Get access to this novel treatment for Kidney Neoplasms by sharing your contact details with the study coordinator.