5-hydroxytryptophan for Allergic Asthma

Phase-Based Progress Estimates
Indiana University, Indianapolis, INAllergic Asthma5-Hydroxytryptophan - Drug
8 - 18
All Sexes
What conditions do you have?

Study Summary

This trial is to study the effects of 5HTP on breathing and anxiety symptoms related to asthma. Subjects will be randomly assigned to take 5HTP or a placebo, then will switch at the halfway point. There are 5 study visits over 12 weeks.

Eligible Conditions
  • Allergic Asthma

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

1 Primary · 2 Secondary · Reporting Duration: 77 days

77 days
Blood will be obtained to assess Eosinophil Count
Pulmonary Function Testing will be performed to assess for a change in Forced Expiratory Volume at one second (FEV1)

Trial Safety

Safety Progress

2 of 3
This is further along than 68% of similar trials

Trial Design

2 Treatment Groups

1 of 2
1 of 2

Active Control

Non-Treatment Group

20 Total Participants · 2 Treatment Groups

Primary Treatment: 5-hydroxytryptophan · Has Placebo Group · Phase 2

PlaceboComparator Group · 1 Intervention: Placebo · Intervention Types: Drug
ActiveComparator Group · 1 Intervention: 5-Hydroxytryptophan · Intervention Types: Drug

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: 77 days

Who is running the clinical trial?

Indiana UniversityLead Sponsor
893 Previous Clinical Trials
766,687 Total Patients Enrolled
Kirsten Kloepfer, MDPrincipal InvestigatorIndiana University
1 Previous Clinical Trials
180 Total Patients Enrolled

Eligibility Criteria

Age 8 - 18 · All Participants · 7 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
You have asthma that is not severe according to the American Thoracic Society guidelines.
Based on your answers to a depression or anxiety questionnaire, your score is above a certain number that indicates possible depression or anxiety.

Frequently Asked Questions

Is the study open to senior citizens as participants?

"This clinical trial requires prospective participants to be between the ages of 8 and 17. There are 112 trials specifically aimed at youths below 18 years old, as well as 198 for those above 65." - Anonymous Online Contributor

Unverified Answer

Might I have the opportunity to join this research endeavor?

"This trial requires that applicants have a diagnosis of asthma, are aged between 8 and 17 years old, and out of the 20 total participants being recruited." - Anonymous Online Contributor

Unverified Answer

Has the Federal Drug Administration sanctioned 5-hydroxytryptophan for clinical use?

"There exists some evidence for 5-hydroxytryptophan's safety, so it was rated a 2 on our scale. Unfortunately there is no efficacy data at this stage of the clinical trial." - Anonymous Online Contributor

Unverified Answer

Are there any opportunities to join this clinical exploration?

"This clinical trial, which was initially posted on September 12th 2019, is currently in the process of finding participants. The details have been recently updated as of January 20th 2022 according to information found through clinicaltrials.gov." - Anonymous Online Contributor

Unverified Answer

How many participants have been recruited to this trial?

"Affirmative. Clinicaltrials.gov discloses that this research initiative, which was initially announced on September 12th 2019, is still recruiting participants. Around 20 subjects need to be enrolled from a single medical site." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.