54 Participants Needed

Platelet Rich Plasma vs Corticosteroids for Hip Osteoarthritis

MG
Overseen ByMartin Gesheff, DHSc
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)
Prior Safety DataThis treatment has passed at least one previous human trial

Trial Summary

Will I have to stop taking my current medications?

The trial information does not specify if you need to stop taking your current medications. However, if you are taking opioids or have had recent injections in the hip, you may not be eligible to participate.

What data supports the effectiveness of the treatment for hip osteoarthritis?

Research shows that platelet-rich plasma (PRP) injections can lead to long-term pain reduction and improved function in patients with hip osteoarthritis, with benefits lasting up to 12 months. Corticosteroids are known to provide immediate pain relief and improve mobility, although their long-term effectiveness is limited.12345

Is platelet-rich plasma (PRP) safe for treating osteoarthritis?

Platelet-rich plasma (PRP) is generally considered safe for treating osteoarthritis, with fewer side effects compared to corticosteroids, as it uses the patient's own blood.26789

How does the treatment of platelet-rich plasma and corticosteroids differ from other treatments for hip osteoarthritis?

Platelet-rich plasma (PRP) and corticosteroids are used as intra-articular injections (injections into the joint) for hip osteoarthritis, with corticosteroids providing short-term pain relief and PRP potentially offering more mid-term benefits. This treatment is unique because it combines the immediate effects of corticosteroids with the regenerative potential of PRP, unlike other treatments like hyaluronic acid, which primarily focuses on lubrication.110111213

What is the purpose of this trial?

Prospective, single-center that may go on to being multicenter, randomized trial comparing platelet rich plasma (PRP) versus corticosteroid injection for the treatment of symptoms of Hip osteoarthritis. The purpose of the study is to determine which therapy provides a greater reduction in patient reported outcome measures of pain and function.

Eligibility Criteria

This trial is for individuals with hip osteoarthritis who are experiencing pain and functional issues. Specific eligibility criteria details were not provided, so it's important to contact the study organizers for more information on who can participate.

Inclusion Criteria

I am between 21 and 80 years old.
I am recommended to get a hip injection for my hip arthritis symptoms.
Provision of signed and dated informed consent form
See 2 more

Exclusion Criteria

I haven't had injections in my hip in the last 3 months.
I have a skin infection over the area of interest.
Allergy to any potential ingredients or medications utilized in any of the two groups
See 6 more

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive either a 5 mL injection of corticosteroid or approximately 10 mL of autologous PRP for the treatment of hip osteoarthritis

6 weeks
3 visits (in-person)

Follow-up

Participants are monitored for safety and effectiveness after treatment, with assessments at baseline, six weeks, and three months

3 months
3 visits (in-person)

Treatment Details

Interventions

  • Corticosteroid
  • Platelet Rich Plasma
Trial Overview The trial is comparing two treatments: platelet rich plasma (PRP) injections versus corticosteroid injections in patients with hip osteoarthritis. It aims to see which treatment better reduces pain and improves function according to patient reports.
Participant Groups
2Treatment groups
Experimental Treatment
Active Control
Group I: Autologous Platelet Rich PlasmaExperimental Treatment1 Intervention
\~Injection of approximately 10 mL autologous PRP Magellan Autologous Concentration System, ISTO Biologics
Group II: CorticosteroidActive Control1 Intervention
5 milliliters (mL) injection of corticosteroid (1cc Kenalog, 4cc Xylocaine) Kenalog - 40 (triamcinolone acetonide injectable suspension, USP) Xylocaine - MPF (lidocaine HCl Injection, USP)

Find a Clinic Near You

Who Is Running the Clinical Trial?

LifeBridge Health

Lead Sponsor

Trials
32
Recruited
4,500+

Hip Society

Collaborator

Trials
1
Recruited
50+

Findings from Research

A systematic review of six studies involving 408 patients found that both platelet-rich plasma (PRP) and hyaluronic acid (HA) injections provide similar short-term clinical benefits for treating hip osteoarthritis, with no significant differences in pain and function scores after treatment.
The analysis included patients with a mean age of around 60 years and a follow-up period of approximately 12 months, indicating that both treatments are effective options for managing symptoms of hip OA.
Platelet-Rich Plasma Versus Hyaluronic Acid for Hip Osteoarthritis Yields Similarly Beneficial Short-Term Clinical Outcomes: A Systematic Review and Meta-analysis of Level I and II Randomized Controlled Trials.Belk, JW., Houck, DA., Littlefield, CP., et al.[2022]
A one-time injection of platelet-rich plasma (PRP) significantly reduced knee pain and improved daily living activities and quality of life in patients with osteoarthritis compared to corticosteroid injections, based on a study of 41 participants over 6 months.
PRP treatment showed better outcomes in pain relief and functional improvement (measured by the 20-Meter-Walk Test) than corticosteroids, although neither treatment affected the range of motion in the knee.
Effect of single injection of platelet-rich plasma in comparison with corticosteroid on knee osteoarthritis: a double-blind randomized clinical trial.Forogh, B., Mianehsaz, E., Shoaee, S., et al.[2022]
In a study of 40 patients with mild to moderate knee osteoarthritis, both platelet-rich plasma (PRP) and corticosteroid (CS) injections were found to be safe and effective for short-term pain relief and improved knee function, with no serious adverse effects reported.
However, PRP showed statistically significant improvements in pain and function compared to CS at the 15-week mark and continued to outperform CS at the 1-year follow-up, suggesting better long-term benefits of PRP for osteoarthritis treatment.
Intra-articular platelet-rich plasma vs corticosteroids in the treatment of moderate knee osteoarthritis: a single-center prospective randomized controlled study with a 1-year follow up.Elksniņš-Finogejevs, A., Vidal, L., Peredistijs, A.[2021]

References

Platelet-Rich Plasma Versus Hyaluronic Acid for Hip Osteoarthritis Yields Similarly Beneficial Short-Term Clinical Outcomes: A Systematic Review and Meta-analysis of Level I and II Randomized Controlled Trials. [2022]
Effect of single injection of platelet-rich plasma in comparison with corticosteroid on knee osteoarthritis: a double-blind randomized clinical trial. [2022]
Intra-articular platelet-rich plasma vs corticosteroids in the treatment of moderate knee osteoarthritis: a single-center prospective randomized controlled study with a 1-year follow up. [2021]
The use of ultrasound-guided platelet-rich plasma injections in the treatment of hip osteoarthritis: a systematic review of the literature. [2020]
Treatment of Early Hip Osteoarthritis: Ultrasound-Guided Platelet Rich Plasma versus Hyaluronic Acid Injections in a Randomized Clinical Trial. [2020]
Comparative Effect between Infiltration of Platelet-rich Plasma and the Use of Corticosteroids in the Treatment of Knee Osteoarthritis: A Prospective and Randomized Clinical Trial. [2020]
Effects of corticosteroids and platelet-rich plasma on synoviocytes in IL-1ß-induced inflammatory condition. [2022]
Does Platelet-rich Plasma Augmentation Following Hip Arthroscopy Improve Outcomes: A Systematic Review. [2020]
Efficacy of platelet-rich plasma and plasma for symptomatic treatment of knee osteoarthritis: a double-blinded placebo-controlled randomized clinical trial. [2022]
10.United Statespubmed.ncbi.nlm.nih.gov
Editorial Commentary: Intra-articular Injection for Osteoarthritis-Is It Hip or Not? [2020]
Intra-articular hyaluronic acid vs platelet-rich plasma in the treatment of hip osteoarthritis. [2022]
12.United Statespubmed.ncbi.nlm.nih.gov
Ultrasound-Guided Injection of Platelet-Rich Plasma and Hyaluronic Acid, Separately and in Combination, for Hip Osteoarthritis: A Randomized Controlled Study. [2018]
[Platelet rich plasma versus oral paracetamol for the treatment of early knee osteoarthritis. Preliminary study]. [2018]
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