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Radiation Therapy

Spinal Radiosurgery with MR-LINAC for Spinal Diseases

Phase 2
Recruiting
Led By Debra N. Yeboa, MD
Research Sponsored by M.D. Anderson Cancer Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Diagnosis of cancer documented
Maximum of 3 contiguous vertebral levels involved with metastasis in the spine to be irradiated allowed
Timeline
Screening 3 weeks
Treatment Varies
Follow Up through study completion; an average of 1 year
Awards & highlights

Study Summary

This trial will test if using MR-LINAC imaging with spinal radiation (SRSS) helps improve responses & quality of life.

Who is the study for?
This trial is for adults over 18 with spinal diseases due to cancer metastasis, affecting up to 3 spine levels. They must be able to undergo MRI with contrast and not have conditions like lymphoma or multiple myeloma that respond well to standard radiation. Pregnant individuals can't participate.Check my eligibility
What is being tested?
The study tests if advanced imaging (MRI) combined with a Linear Accelerator (MR-LINAC) during Spinal Stereotactic Radiosurgery (SRSS) improves treatment response and quality of life compared to traditional methods.See study design
What are the potential side effects?
Potential side effects may include skin reactions, fatigue, inflammation around the spine, changes in bowel or bladder habits, and rarely nerve damage which could affect muscle strength and sensation.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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My cancer diagnosis is officially recorded.
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My spine cancer has spread to no more than 3 connected vertebrae.
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My muscle strength in the limb affected by my spinal condition is good.
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I am 18 years old or older.
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I can care for myself but may not be able to do active work.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~through study completion; an average of 1 year
This trial's timeline: 3 weeks for screening, Varies for treatment, and through study completion; an average of 1 year for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
M. D. Anderson Symptom Inventory - Spine Tumor (MDASI-SP) questionnaires

Trial Design

2Treatment groups
Experimental Treatment
Group I: Group 2 (Imaging-only Cohort)Experimental Treatment2 Interventions
Participants in Group 2 will receive spine radiosurgery using a standard radiation therapy machine and have the opportunity to get imaging on the MR LINAC.
Group II: Group 1 (Therapeutic Cohort)Experimental Treatment3 Interventions
Participants in Group 1 will receive spine radiosurgery on the MR LINAC machine, along with imaging scans using the same machine.

Find a Location

Who is running the clinical trial?

M.D. Anderson Cancer CenterLead Sponsor
2,962 Previous Clinical Trials
1,803,325 Total Patients Enrolled
2 Trials studying Spinal Diseases
52 Patients Enrolled for Spinal Diseases
Debra N. Yeboa, MDPrincipal InvestigatorM.D. Anderson Cancer Center

Media Library

MR-LINAC (Radiation Therapy) Clinical Trial Eligibility Overview. Trial Name: NCT05709782 — Phase 2
Spinal Diseases Research Study Groups: Group 1 (Therapeutic Cohort), Group 2 (Imaging-only Cohort)
Spinal Diseases Clinical Trial 2023: MR-LINAC Highlights & Side Effects. Trial Name: NCT05709782 — Phase 2
MR-LINAC (Radiation Therapy) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05709782 — Phase 2

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

To what extent are individuals in Group 1 (Therapeutic Cohort) at risk?

"The safety of Group 1 (Therapeutic Cohort) was assessed at a 2 on our scale, as this is Phase 2 trial with data indicating its security but not yet validating its efficacy."

Answered by AI

Are new participants being welcomed into this experiment?

"As documented on clinicaltrials.gov, this medical study is not currently recruiting participants; the original posting was made back in June 30th 2023 and last modified January 24th 2021. Despite that, there are 38 alternative trials actively searching for volunteers at present."

Answered by AI
~22 spots leftby Mar 2025