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Light Therapy for Depression

N/A
Recruiting
Led By Adriane M Soehner, PhD
Research Sponsored by University of Pittsburgh
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be younger than 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up collected during the blue and red light exposures during the mri scan at the lab visit
Awards & highlights

Study Summary

This trial will study if blue light helps stabilize emotional brain function in depression and if it has a stronger effect in adolescents than young adults.

Who is the study for?
This trial is for adolescents and young adults with depression who can read and write in English, have no severe medical or neurological issues, are not pregnant or nursing, and haven't had substance/alcohol problems recently. Participants must be right-handed, not color-blind, off most psychotropic meds except stable SSRIs, and able to maintain a regular sleep schedule.Check my eligibility
What is being tested?
The study tests the effects of blue light versus red light on emotional brain function using MRI scans while participants respond to rewards and losses. It also includes pupillometry to measure light sensitivity, clinical interviews, surveys about mood and health habits like sleep which is tracked at home for a week.See study design
What are the potential side effects?
There may be minimal side effects from exposure to different lights; however specific risks aren't detailed here. The MRI scan could cause discomfort for those with claustrophobia or anxiety related to enclosed spaces.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~collected during the blue and red light exposures during the mri scan at the lab visit
This trial's timeline: 3 weeks for screening, Varies for treatment, and collected during the blue and red light exposures during the mri scan at the lab visit for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Amygdala activity (loss>neutral) during Blue vs Red light exposure
Amygdala cerebral blood flow during Blue vs Red light exposure
Ventral Striatum activity (punish>neutral) during Blue vs Red light exposure
+1 more
Secondary outcome measures
Amygdala-whole brain functional connectivity (loss>neutral) during Blue vs Red light exposure
Insula activity (loss>neutral) during Blue vs Red light exposure
Insula cerebral blood flow during Blue vs Red light exposure
+6 more

Trial Design

2Treatment groups
Experimental Treatment
Group I: Red Light then Blue LightExperimental Treatment2 Interventions
Red light (640 nm) then Blue light (480 nm)
Group II: Blue then Red LightExperimental Treatment2 Interventions
Blue light (480 nm) then Red light (640 nm)

Find a Location

Who is running the clinical trial?

National Institute of Mental Health (NIMH)NIH
2,786 Previous Clinical Trials
2,689,629 Total Patients Enrolled
666 Trials studying Depression
251,504 Patients Enrolled for Depression
University of PittsburghLead Sponsor
1,723 Previous Clinical Trials
16,343,076 Total Patients Enrolled
119 Trials studying Depression
34,015 Patients Enrolled for Depression
Adriane M Soehner, PhDPrincipal InvestigatorUniversity of Pittsburgh

Media Library

Blue Light Clinical Trial Eligibility Overview. Trial Name: NCT05712772 — N/A
Depression Research Study Groups: Blue then Red Light, Red Light then Blue Light
Depression Clinical Trial 2023: Blue Light Highlights & Side Effects. Trial Name: NCT05712772 — N/A
Blue Light 2023 Treatment Timeline for Medical Study. Trial Name: NCT05712772 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is this experiment open to adults over 25?

"This clinical investigation has a lower threshold of 12 years old and an upper boundary of 30 for potential participants."

Answered by AI

Does this research study still require participants?

"According to clinicaltrials.gov, this prescreened trial is not currently open for recruitment; it was first posted on March 15th 2023 and its activity status was last updated in January 25th of the same year. That being said, there are over twelve hundred other trials actively searching for participants at present."

Answered by AI

Do I meet the qualifications for participation in this experiment?

"This research is seeking 80 adolescents between 12 and 30 years old, who have been diagnosed with teen depression according to the DSM-5 criteria. Additionally, if a participant is younger than 18 their parent or legal guardian must be present for baseline assessment interviews."

Answered by AI

What results are anticipated from the completion of this trial?

"This trial aims to analyze and compare the Ventral Striatum cerebral blood flow during Blue vs Red light exposure, collected over the course of an MRI scan. Secondary objectives include assessing Insula cerebral blood flow via pseudo-continuous arterial spin labeling, in addition to evaluating Ventromedial prefrontal cortex cerebral blood flow and Amygdala-whole brain functional connectivity (loss>neutral) during a computerized fMRI behavioral task."

Answered by AI

Who else is applying?

What site did they apply to?
Western Psychiatric Hospital
What portion of applicants met pre-screening criteria?
Met criteria
How many prior treatments have patients received?
3+

Why did patients apply to this trial?

Recent research and studies
clinicaltrials.govStudy
Neuro-affective Response to Light in Depressed Adolescents and Young Adults
Adriane Soehner 2023. "Neuro-affective Response to Light in Depressed Adolescents and Young Adults". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05712772.
~18 spots leftby Jul 2024
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