TMS for Depression
(T5 Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
The goal of this clinical trial is to test a new brain stimulation treatment target for individuals with depression plus at least one additional psychiatric disorder. The main question is to understand the safety profile of a non-invasive form of brain stimulation called accelerated intermittent theta burst stimulation when it is targeting the posterior parietal cortex. Additional questions focus on whether this stimulation improves symptoms of depression and other psychiatric disorders as well as whether this stimulation changes brain function.
Will I have to stop taking my current medications?
Participants must have a stable psychiatric medication regimen or be medication-free for 4 weeks before starting the trial and must continue this regimen throughout the study until two weeks after treatment.
Is Transcranial Magnetic Stimulation (TMS) safe for humans?
How is the treatment rTMS for depression different from other treatments?
Repetitive transcranial magnetic stimulation (rTMS) is unique because it uses magnetic fields to stimulate nerve cells in the brain, which is different from medications that work chemically. It is a non-invasive procedure, meaning it doesn't require surgery or medication, and is often used when other treatments haven't worked.678910
What data supports the effectiveness of the treatment Transcranial Magnetic Stimulation (TMS) for depression?
Research shows that repetitive transcranial magnetic stimulation (rTMS) is generally well tolerated and more effective than a placebo treatment for depression, with some studies indicating improved outcomes over time. It has been found to be effective in both short-term and some long-term cases, especially in patients who have not responded to other treatments.710111213
Who Is on the Research Team?
Joseph J Taylor, MD, PhD
Principal Investigator
Brigham and Women's Hospital
Are You a Good Fit for This Trial?
This trial is for adults aged 18-65 with depression and another psychiatric disorder like anxiety, OCD, or PTSD. Participants must speak English well enough for consent and treatment, have a stable medication regimen or be medication-free for four weeks prior to the study, and show moderate to severe treatment resistance.Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive accelerated intermittent theta burst stimulation (iTBS) targeting the posterior parietal cortex, with 10 sessions per day for 5 consecutive days
Follow-up
Participants are monitored for safety and effectiveness after treatment, with assessments at multiple intervals
What Are the Treatments Tested in This Trial?
Interventions
- Transcranial Magnetic Stimulation
Transcranial Magnetic Stimulation is already approved in United States, Canada, European Union for the following indications:
Find a Clinic Near You
Who Is Running the Clinical Trial?
Brigham and Women's Hospital
Lead Sponsor