RTN-001 for High Blood Pressure
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial aims to determine if the drug RTN-001 can effectively lower high blood pressure (hypertension) in adults who have not controlled it with at least two different medications. The study will also monitor any side effects from RTN-001. Participants will take either the actual drug or a placebo (a look-alike pill with no active ingredients) daily for 12 weeks. Suitable candidates have high blood pressure that remains uncontrolled despite using at least two different types of blood pressure medications. As a Phase 2 trial, this research measures how well RTN-001 works in an initial, smaller group of people, offering participants a chance to contribute to important medical advancements.
Do I have to stop taking my current medications for the trial?
No, you do not have to stop taking your current medications. The trial requires participants to be on a stable regimen of at least two antihypertensive medications. However, you must pause the use of PDE5 inhibitors for erectile dysfunction during the study.
Is there any evidence suggesting that RTN-001 is likely to be safe for humans?
Research has shown that RTN-001 was well tolerated in earlier studies. Participants experienced significant drops in blood pressure without major side effects. These studies suggest that the treatment is generally safe for people with high blood pressure. So far, RTN-001 has been used alongside standard blood pressure medications and has shown good results. While this trial will provide more information, existing research supports its safety in humans.12345
Why do researchers think this study treatment might be promising?
RTN-001 is unique because it offers a fresh approach to managing high blood pressure by potentially targeting novel pathways in the body. Unlike standard treatments, which often include ACE inhibitors, beta-blockers, or diuretics, RTN-001 might work through a different mechanism, though specifics are still under exploration. Researchers are excited about this treatment because it could offer an alternative for patients who don't respond well to existing medications, and its oral tablet form ensures easy administration.
What evidence suggests that RTN-001 might be an effective treatment for high blood pressure?
Studies have shown that RTN-001, which participants in this trial may receive, can significantly lower blood pressure in people with hypertension. Previous patients reported that it was well tolerated, with few serious side effects. Research found that RTN-001 led to noticeable drops in blood pressure readings. This suggests that RTN-001 could be a promising treatment for those with difficult-to-control high blood pressure. The evidence supports RTN-001 as a potential option to help manage high blood pressure effectively.13456
Who Is on the Research Team?
William CMO, PhD
Principal Investigator
CMO
Are You a Good Fit for This Trial?
This trial is for adults aged 18-70 with uncontrolled high blood pressure despite taking at least two different types of blood pressure medications. Participants must be in good general health, not pregnant or able to become pregnant (or using reliable contraception), and have a BMI between 18 and 35.Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Run-in
Single-blind period to assess patient compliance and ability to undergo 24-hour ambulatory BP measurement
Treatment
Participants receive RTN-001 or placebo daily for 12 weeks with regular BP measurements and blood sampling
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- RTN-001
Find a Clinic Near You
Who Is Running the Clinical Trial?
Retension Pharmaceuticals. Inc.
Lead Sponsor