This study is a randomized, placebo-controlled double-blinded clinical trial of patients presenting with acetaminophen poisoning who are at increased risk of developing liver injury. With this trial the investigators are hoping to show the superiority of acetylcysteine (NAC) + fomepizole (4-MP) compared to treatment with acetylcysteine alone. The primary objective of this trial is to determine the effect of fomepizole on the severity of acute liver injury in patients with acetaminophen poisoning.
2 Primary · 10 Secondary · Reporting Duration: Fomepizole serum concentration will be measured at 2, 5, 12, 20, 32, 44, etc. hours after starting NAC (and every 12 hours afterwards) as long as patient is receiving medication (either NAC or NAC and 4-MP), two to three days on average.
40 Total Participants · 2 Treatment Groups
Primary Treatment: N-acetylcysteine (NAC) and Fomepizole (4-MP) (Study) · No Placebo Group · Phase 2
Age 18 - 99 · All Participants · 7 Total Inclusion CriteriaMark “Yes” if the following statements are true for you: