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SGLT2 Inhibitor

SGLT2 Inhibitor for Cystic Fibrosis-related Diabetes

Phase 2 & 3
Recruiting
Research Sponsored by Amir Moheet
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Adult subjects 18 years or older with CFRD and on insulin treatment
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up duration of anticipated participation for an individual participant's would be around 15 weeks.duration anticipated to complete all study procedures, including any long-term follow-up, and data analysis is 24 months.
Awards & highlights

Study Summary

This trial tests if a new diabetes drug is safe and tolerated in overweight/obese patients with chronic fatigue-related diabetes.

Who is the study for?
This trial is for overweight or obese adults (BMI >25) aged 18+ with Cystic Fibrosis-related Diabetes (CFRD) who are on insulin. Participants capable of pregnancy must use effective contraception. Excluded are those with recent severe lung issues, chronic kidney disease, organ transplants, non-English speakers, new CFTR therapy users within 12 weeks, Type 1 diabetes patients, and individuals with a history of certain infections or eating disorders.Check my eligibility
What is being tested?
The study tests the safety and effectiveness of Empagliflozin in CFRD patients compared to a placebo. It's designed as a double-blind crossover study—meaning participants will receive both the drug and placebo at different times without knowing which one they're taking—with a break period between treatments.See study design
What are the potential side effects?
Potential side effects from Empagliflozin may include urinary tract infections, dehydration leading to low blood pressure, ketoacidosis (a serious condition related to diabetes), genital yeast infections in women and men, increased cholesterol levels and allergic reactions.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am 18 or older with cystic fibrosis-related diabetes and on insulin.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~duration of anticipated participation for an individual participant's would be around 15 weeks.duration anticipated to complete all study procedures, including any long-term follow-up, and data analysis is 24 months.
This trial's timeline: 3 weeks for screening, Varies for treatment, and duration of anticipated participation for an individual participant's would be around 15 weeks.duration anticipated to complete all study procedures, including any long-term follow-up, and data analysis is 24 months. for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Feasibility, safety, tolerability

Trial Design

2Treatment groups
Active Control
Placebo Group
Group I: empagliflozinActive Control1 Intervention
randomized to study medication (empagliflozin) 10 mg taken by mouth daily for 4 weeks
Group II: placebo controlPlacebo Group1 Intervention
randomized to placebo control taken by mouth daily for 4 weeks

Find a Location

Who is running the clinical trial?

Amir MoheetLead Sponsor
1 Previous Clinical Trials
15 Total Patients Enrolled
1 Trials studying Cystic Fibrosis
15 Patients Enrolled for Cystic Fibrosis

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is this study in need of new participants?

"The clinicaltrials.gov website indicates that this trial, which was initially made accessible on December 30th 2023 and most recently modified on November 20th 2023, is not currently open to volunteers. Nevertheless, 1987 other medical trials are actively recruiting participants at the present moment."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
SGLT2 Inhibitor Therapy in Cystic Fibrosis-related Diabetes
Amir Moheet 2023. "SGLT2 Inhibitor Therapy in Cystic Fibrosis-related Diabetes". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT06149793.
All > Cystic Fibrosis > Paid Studies Minneapolis
~10 spots leftby Dec 2025
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