Monitoring Tools for Sepsis-Related Frailty
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial aims to explore how severe abdominal infections, known as sepsis, impact frailty, which includes weakness, slowness, and loss of muscle mass. Researchers seek to understand how these infections affect mobility and the ability to perform daily tasks. They use tools like imaging tests (such as computed tomography morphometrics), activity monitors, and mobility assessments to gather data. The trial is best suited for surgical ICU patients who have experienced sepsis, particularly those with abdominal infections. As an unphased trial, this study offers patients the chance to contribute to groundbreaking research that could enhance understanding and treatment of sepsis-related frailty.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. However, if you are on chemotherapy, radiotherapy, or immunosuppressive agents, you may not be eligible to participate.
What prior data suggests that these monitoring tools are safe for sepsis-related frailty?
Research has shown that the tools and methods used in this study are generally safe for people. For CT scans, studies have found them crucial for doctors to locate infection sites in patients with sepsis. Although CT scans are commonly used and well-tolerated, they do involve some radiation exposure.
Frailty measurements are also part of this study. These assessments help predict health risks in older adults with sepsis. Being non-invasive, they don't involve surgery or entering the body, making them safe.
Mobility monitors, such as wearable devices, track movement and activity. Studies show they can help detect health changes early. These devices are usually safe and easy to wear.
Lastly, the Modified Minnesota Leisure Time Activities questionnaire measures physical activity. This simple survey method poses no risk to participants.
Overall, the tools in this study are widely accepted and safe. They help doctors understand how severe infections affect health, especially in older people.12345Why are researchers excited about this trial?
Researchers are excited about these new monitoring tools for sepsis-related frailty because they offer a comprehensive approach that goes beyond traditional treatments. Unlike standard methods that primarily focus on managing infection, these tools incorporate frailty measurements, mobility monitors, and specialized activity tracking to better understand a patient's overall health status. By using computed tomography morphometrics, they can precisely measure body composition changes, providing insights into how sepsis impacts physical resilience. This holistic approach could lead to more personalized treatments, potentially improving recovery outcomes for patients with sepsis.
What evidence suggests that this trial's monitoring tools could be effective for sepsis-related frailty?
This trial will use various monitoring tools to understand sepsis-related frailty. Research has shown that frailty and muscle loss can worsen outcomes for people with sepsis. In this trial, CT scans will identify muscle loss, which links to slower recovery. Frailty measurements will predict negative outcomes, as frail patients often face more challenges in recovery. Mobility monitors will track movement to uncover difficulties in physical activity after sepsis, which is crucial for understanding recovery. Finally, the Modified Minnesota Leisure Time Activities questionnaire will assess physical activity levels, indicating overall health and recovery potential. Together, these tools aim to improve outcomes for sepsis patients.24678
Who Is on the Research Team?
Philip Efron, MD
Principal Investigator
University of Florida
Are You a Good Fit for This Trial?
This trial is for adults over 18 who are in the surgical or trauma ICU with a diagnosis of sepsis, severe sepsis, or septic shock. They must be part of the standard-care sepsis protocol and able to give consent themselves or through a legal representative.Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
In-Hospital Monitoring
Participants are monitored for frailty, comorbidity, and disability during their hospital stay after intra-abdominal sepsis
Post-Discharge Monitoring
Participants are monitored for changes in frailty, mobility, and sarcopenia at 3, 6, and 12 months post-discharge
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Computed tomography morphometrics
- Frailty Measurements
- Mobility Monitors
- Modified Minnesota Leisure Time Activities
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Florida
Lead Sponsor
National Institute on Aging (NIA)
Collaborator
National Institutes of Health (NIH)
Collaborator