Advil Dual Action for Pain
Trial Summary
Will I have to stop taking my current medications?
Yes, you will need to stop taking any medications, including over-the-counter drugs and herbal remedies, at least 2 weeks before the study starts, unless they are systemic contraceptives that you've been using consistently for at least 3 months.
What data supports the effectiveness of the drug Advil Dual Action Liquid Filled Capsules?
Research shows that ibuprofen, a component of Advil Dual Action, is effective in providing faster pain relief compared to some other pain medications, like celecoxib, especially in cases of dental pain. Additionally, liquid capsule formulations, like those used for diclofenac, are absorbed more quickly, which can lead to faster pain relief.12345
Is Advil Dual Action generally safe for humans?
How is Advil Dual Action different from other pain relief drugs?
Advil Dual Action Liquid Filled Capsules are unique because they combine two active ingredients, ibuprofen and acetaminophen, which work together to provide pain relief. This combination allows for effective pain management with potentially fewer side effects compared to using higher doses of a single ingredient.1251011
What is the purpose of this trial?
The primary purpose of this study is to demonstrate the bioequivalence of new formulation Advil Dual Action (ADA) liquid filled capsules (Test) compared to the currently marketed ADA Caplet (Reference) under fasted conditions and to assess the relative bioavailability of ADA liquid filled capsules (Test) under fed conditions compared to ADA liquid filled capsules (Reference) under fasted conditions.
Eligibility Criteria
Healthy adults aged 18-55, with a BMI of 18.5 to 30 kg/m^2, can join this pain medication study if they agree to use contraception and follow the study plan. Excluded are those with certain health conditions, drug/alcohol abuse history, recent participation in other studies or blood donations.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive a single oral dose of investigational products in a four-treatment, four-period, four-sequence crossover design with a washout period of 3 days between treatments.
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- Advil Dual Action Liquid Filled Capsules
Find a Clinic Near You
Who Is Running the Clinical Trial?
HALEON
Lead Sponsor