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FTT PET/CT Imaging for Breast Cancer

Phase 1
Waitlist Available
Led By Elizabeth McDonald, MD
Research Sponsored by Abramson Cancer Center of the University of Pennsylvania
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Known or suspected (BIRADS 5 on imaging) primary breast cancer
At least one breast lesion one breast lesion that is 1 cm or greater in size by standard imaging (e.g. mammography, ultrasound or breast MRI). Only one type of imaging is required to show a lesion of 1 cm or greater in order for the patient to be eligible to participate in this study. Patients that have a prior diagnosis of primary breast cancer in the opposite breast can be included.
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 2 years
Awards & highlights

Study Summary

This trial is testing whether FTT PET/CT can help predict how well a patient will respond to breast cancer surgery or neoadjuvant therapy.

Who is the study for?
This trial is for adults over 18 with suspected or confirmed breast cancer, showing a lesion of at least 1 cm on imaging. Participants must be willing to provide tissue samples and consent to research use. It's not suitable for those who can't tolerate imaging procedures, have conditions compromising safety/participation, or are pregnant/breastfeeding.Check my eligibility
What is being tested?
[18F]FluorThanatrace (FTT) PET/CT scans are being tested in up to 30 participants before surgery or therapy for breast cancer. The study may include a second scan after starting therapy to correlate FTT uptake with pathology and treatment response.See study design
What are the potential side effects?
While the description doesn't list specific side effects of [18F]FluorThanatrace, typical PET/CT scan risks include exposure to radiation, potential allergic reactions to tracers, discomfort from lying still during the procedure, and anxiety.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am diagnosed or highly suspected to have primary breast cancer.
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I have a breast lesion that is at least 1 cm large, confirmed by imaging.
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I am 18 years old or older.
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I agree to let my biopsy or surgery samples be used for research.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~2 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and 2 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Number of adverse events

Trial Design

1Treatment groups
Experimental Treatment
Group I: Single ArmExperimental Treatment1 Intervention

Find a Location

Who is running the clinical trial?

Abramson Cancer Center of the University of PennsylvaniaLead Sponsor
359 Previous Clinical Trials
105,105 Total Patients Enrolled
41 Trials studying Breast Cancer
35,343 Patients Enrolled for Breast Cancer
Abramson Cancer Center at Penn MedicineLead Sponsor
383 Previous Clinical Trials
144,861 Total Patients Enrolled
44 Trials studying Breast Cancer
60,859 Patients Enrolled for Breast Cancer
Elizabeth McDonald, MDPrincipal InvestigatorAbramson Cancer Center at Penn Medicine

Media Library

[18F]FluorThanatrace Clinical Trial Eligibility Overview. Trial Name: NCT03083288 — Phase 1
Breast Cancer Research Study Groups: Single Arm
Breast Cancer Clinical Trial 2023: [18F]FluorThanatrace Highlights & Side Effects. Trial Name: NCT03083288 — Phase 1
[18F]FluorThanatrace 2023 Treatment Timeline for Medical Study. Trial Name: NCT03083288 — Phase 1

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are any participants being accepted for this research endeavor currently?

"This investigation, which was initially listed on February 22nd 2017 and most recently updated May 12th 2022, is no longer seeking new participants. However, 2600 other trials are currently recruiting patients at this time."

Answered by AI

How deleterious is [18F]FluorThanatrace to human health?

"The safety of [18F]FluorThanatrace has been assessed as a 1 on our scale due to the limited information available from Phase 1 trials."

Answered by AI
~3 spots leftby Feb 2025