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Nitric Oxide Synthase Inhibitor

Phenylephrine for Vasovagal Syncope

Phase < 1
Waitlist Available
Led By Julian M. Stewart, M.D., Ph.D.
Research Sponsored by New York Medical College
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be younger than 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 1 year
Awards & highlights

Study Summary

This trial will study the effects of a simple molecule, nitric oxide, on people with vasovagal syncope (simple postural faint) or postural tachycardia syndrome (POTS).

Eligible Conditions
  • Vasovagal Syncope
  • Postural Orthostatic Tachycardia Syndrome

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~1 year
This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 year for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Heart rate and blood pressure in response to Lower Body Negative Pressure(LBNP)
Secondary outcome measures
Adrenergic neurotransmission as measured by Muscle Sympathetic Nerve Activity(MSNA), doppler ultrasound blood flow, venous Norepinephrine in response to Phenylephrine infusion

Trial Design

1Treatment groups
Experimental Treatment
Group I: Phenylephrine and L-Ng-monomethyl Arginine (L-NMMA)Experimental Treatment2 Interventions
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Phenylephrine
2014
Completed Phase 4
~2050

Find a Location

Who is running the clinical trial?

New York Medical CollegeLead Sponsor
69 Previous Clinical Trials
5,971 Total Patients Enrolled
1 Trials studying Vasovagal Syncope
30 Patients Enrolled for Vasovagal Syncope
Julian M. Stewart, M.D., Ph.D.Principal InvestigatorNew York Medical College
1 Previous Clinical Trials
51 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Mechanisms of Vasovagal Syncope
Julian Stewart 2013. "Mechanisms of Vasovagal Syncope". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT01791816.
~7 spots leftby Apr 2025
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