Backward Walking Training for Stroke Recovery
(BRAVE Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial aims to evaluate the effectiveness of backward walking training for stroke recovery. Researchers seek to determine whether 18 or 27 sessions better improve walking and balance post-stroke. They will also use MRI scans to study brain activity and understand how the training might alter brain function. Individuals who had a stroke 2–4 months ago and can walk with some assistance may qualify. As an unphased trial, this study provides a unique opportunity to contribute to innovative research that could enhance stroke rehabilitation techniques.
Do I have to stop taking my current medications for the trial?
The trial information does not specify whether you need to stop taking your current medications.
What prior data suggests that this backward walking training is safe for stroke recovery?
Research has shown that walking backward is safe and well-tolerated for people recovering from a stroke. One study found that this type of walking, when combined with other therapies, was both feasible and safe for stroke recovery. Participants in that study generally managed the training well, without major problems. While more research is needed, these findings suggest that backward walking can safely be included in stroke recovery.12345
Why are researchers excited about this trial?
Researchers are excited about backward walking training for stroke recovery because it offers a fresh approach to rehabilitation. Unlike traditional stroke recovery therapies, which often focus on forward movement and general physical therapy, backward walking targets specific neural pathways and muscle groups that are crucial for balance and coordination. The unique aspect of this method is its potential to improve gait and stability by challenging the brain and body in new ways, which could lead to more effective recovery outcomes. Additionally, the simplicity and low-cost nature of backward walking make it an accessible option for many patients, potentially enhancing adherence and long-term benefits.
What evidence suggests that backward walking training is effective for stroke recovery?
Research shows that practicing walking backward can significantly aid stroke recovery by improving walking and balance. Studies have found that this training increases walking speed more effectively than walking forward. A review of several studies found that walking backward is as effective, if not more so, for enhancing walking speed after a stroke. Another study found that participants who practiced walking backward showed noticeable improvements in balance and walking ability. In this trial, participants will be assigned to different groups to receive either 27 or 18 sessions of backward walking training. These findings suggest that backward walking training is a promising method to help stroke survivors regain mobility.26789
Who Is on the Research Team?
Dorian Kay Rose, PhD MS BS
Principal Investigator
North Florida/South Georgia Veterans Health System, Gainesville, FL
Are You a Good Fit for This Trial?
This trial is for post-stroke Veterans who are medically stable, had a unilateral stroke, and have balance and walking speed challenges. They must be 2-4 months post-stroke and able to walk at least 10 feet with minimal assistance. Excluded are those with other neurological conditions, severe heart disease, pain when walking, current physical therapy for mobility/gait, MRI contraindications like metal implants or claustrophobia, serious cardiac issues or severe joint problems.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Baseline Assessment
Baseline pre-intervention assessment including clinical gait and balance assessments and resting state Functional Connectivity MRI and functional MRI
Treatment
Participants receive backward walking training, either 18 sessions over 6 weeks or 27 sessions over 9 weeks
Post-Treatment Assessment
Assessment B to compare gait and balance measures and MRI brain measurements to baseline
Short-term Follow-up
Assessment C to evaluate short-term retention gains in gait and balance
Long-term Follow-up
Assessment D to evaluate long-term retention gains in gait and balance
What Are the Treatments Tested in This Trial?
Interventions
- Backward Walking Training
Find a Clinic Near You
Who Is Running the Clinical Trial?
VA Office of Research and Development
Lead Sponsor