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Behavioral Intervention

High-intensity interval treadmill training for Multiple Sclerosis

N/A

Recruiting

Research Sponsored by University of Illinois at Chicago

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Age ≥21 years

Multiple sclerosis diagnosis

Timeline

Screening 3 weeks

Treatment Varies

Follow Up immediately (within 1 week) before and after training

Awards & highlights

Study Summary

This trial aims to see if high-intensity walking exercise can help improve fatigue and walking problems in people with multiple sclerosis. This could potentially enhance their quality of life and reduce the economic burden associated with the

Who is the study for?

This trial is for people with Multiple Sclerosis who experience fatigue and walking difficulties. Specific eligibility criteria are not provided, but typically participants must meet certain health conditions to ensure safety and effectiveness of the treadmill training intervention.Check my eligibility

What is being tested?

The study investigates if high-intensity gait training on a treadmill can reduce fatigue and improve walking in individuals with Multiple Sclerosis. The goal is to see if this type of exercise could enhance their quality of life.See study design

What are the potential side effects?

While specific side effects are not listed, high-intensity treadmill training may cause muscle soreness, increased fatigue initially, or exacerbate symptoms in some individuals with Multiple Sclerosis.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am 21 years old or older.

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I have been diagnosed with multiple sclerosis.

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My treatment for my condition has not changed in the last 6 months.

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I often feel very tired.

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I can walk for 6 minutes, even with a cane or walker.

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I have difficulty walking due to my condition.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ immediately (within 1 week) before and after training

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~immediately (within 1 week) before and after training

This trial's timeline: 3 weeks for screening, Varies for treatment, and immediately (within 1 week) before and after training for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Corticomotor excitability

Symptomatic fatigue

Walking speed

Secondary outcome measures

Aerobic capacity

Fatigue impact

Verbal learning and memory

+2 more

Other outcome measures

Community ambulation

Interhemispheric inhibition

Spatial walking symmetry

+1 more

Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: High-intensity interval treadmill trainingExperimental Treatment1 Intervention

Walking with high intensity intervals interspersed.

Group II: Moderate-intensity continuous treadmill trainingActive Control1 Intervention

Continuous walking at a moderate intensity

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

treadmill training

2015

N/A

~50

0 / 6Eligibility criteria met

Find a Location

Who is running the clinical trial?

University of Illinois at ChicagoLead Sponsor

609 Previous Clinical Trials

1,559,289 Total Patients Enrolled

13 Trials studying Multiple Sclerosis

1,686 Patients Enrolled for Multiple Sclerosis

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there currently ongoing patient enrollments for this clinical trial?

"According to clinicaltrials.gov, this particular investigation is currently not in search of additional participants. Originally listed on March 1st, 2024, the trial's most recent update was on February 8th, 2024. Despite its closure for recruitment, it’s essential to note that there are a total of 547 alternative clinical trials actively welcoming new patients."

Answered by AI

What is the primary objective of conducting this clinical trial?

"The main focus of this study, to be evaluated immediately before and after the training period, is Corticomotor excitability. Secondary outcomes encompass Fatigue impact as measured by alterations in physical, cognitive, and psychosocial functioning using the Modified Fatigue Impact Scale (MFIS) with scores ranging from 0 to 84; increased values indicate a more pronounced fatigue impact. Furthermore, Walking endurance will be assessed through changes in distance covered during the 6-minute walk test (6mWT), where higher distances signify improved walking endurance. Lastly, Aerobic capacity will be determined via Cardiopulmonary exercise tests conducted on a motorized"

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Effects of High-intensity Gait Training on Fatigue, Gait, and Neuroplasticity in People With Multiple Sclerosis

Brice Cleland 2024. "Effects of High-intensity Gait Training on Fatigue, Gait, and Neuroplasticity in People With Multiple Sclerosis". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT06264336.

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