High-Intensity Gait Training for Multiple Sclerosis

Overseen By Brice T Cleland, PhD

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: University of Illinois at Chicago

Must not be taking: Seizure medications

Disqualifiers: Pregnancy, Cardiac arrhythmia, Diabetes, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Approved in 1 Jurisdiction This treatment is already approved in other countries

Compensation: Varies

Number of Visits: 2

Duration: 6 weeks

20 Participants Needed

What You Need to Know Before You Apply

What is the purpose of this trial?

Nearly 1 million individuals in the United States have multiple sclerosis, which causes fatigue and problems with walking. Fatigue and walking problems are poorly treated, but exercise training, particularly high-intensity walking exercise, may help. This provide insight into whether high-intensity walking exercise can improve fatigue and walking problems in people with multiple sclerosis, which could improve quality of life and reduce economic burden.

Are You a Good Fit for This Trial?

This trial is for people with Multiple Sclerosis who experience fatigue and walking difficulties. Specific eligibility criteria are not provided, but typically participants must meet certain health conditions to ensure safety and effectiveness of the treadmill training intervention.

Inclusion Criteria

I am 21 years old or older.

I have been diagnosed with multiple sclerosis.

My treatment for my condition has not changed in the last 6 months.

Exclusion Criteria

Prisoners

Significant cognitive or communication impairment (Mini-Mental State Examination (MMSE)<21), which could impede the understanding of the purpose of procedures of the study or prevent the patient from performing the ankle-tracking task

I have been diagnosed with severe osteoporosis.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants undergo either moderate-intensity continuous treadmill training or high-intensity interval treadmill training to improve fatigue and walking in people with MS

6 weeks

2 visits per week (in-person)

Follow-up

Participants are monitored for changes in corticomotor excitability, fatigue impact, walking speed, and other outcomes immediately before and after training

1 week

What Are the Treatments Tested in This Trial?

Interventions

• Treadmill Training

Trial Overview The study investigates if high-intensity gait training on a treadmill can reduce fatigue and improve walking in individuals with Multiple Sclerosis. The goal is to see if this type of exercise could enhance their quality of life.

How Is the Trial Designed?

Group I: High-intensity interval treadmill training Experimental Treatment 1 Intervention

Walking with high intensity intervals interspersed.

Group II: Moderate-intensity continuous treadmill training Active Control 1 Intervention

Continuous walking at a moderate intensity

Treadmill Training is already approved in China for the following indications:

Approved in China as Remote Ischemic Conditioning for:

• Acute moderate ischemic stroke

Who Is Running the Clinical Trial?

University of Illinois at Chicago

Lead Sponsor

Trials

653

Recruited

1,574,000+