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Prehospital Sepsis Protocol for Sepsis (IMPRESS Trial)

N/A

Recruiting

Led By Carmen C Polito, MD, MSc

Research Sponsored by Emory University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up during hospital stay (up to 20 days, on average)

Awards & highlights

IMPRESS Trial Summary

This trial will test if an emergency medical services (EMS) based sepsis screening and early warning protocol can improve the timing of sepsis care in the emergency department (ED).

Who is the study for?

This trial is for adults who have signs of sepsis, like a fast pulse rate over 90 bpm, low blood pressure under 110 mmHg, or rapid breathing over 20 breaths per minute. They must be transported by EMS to a participating hospital and meet other criteria such as being aged 40+, having a high temperature or low oxygen levels. Pregnant individuals and those with trauma, cardiac arrest, psychiatric emergencies or toxic ingestion are excluded.Check my eligibility

What is being tested?

The study tests the 'PRESS Intervention', which is an early warning protocol used by emergency services to identify and start treatment for sepsis before reaching the hospital. The goal is to see if this prehospital procedure can speed up care once patients arrive at the Emergency Department.See study design

What are the potential side effects?

Since this trial focuses on improving response times rather than testing new medications, it does not directly involve side effects from interventions. However, there may be risks associated with delayed or accelerated medical procedures.

IMPRESS Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ during hospital stay (up to 20 days, on average)

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~during hospital stay (up to 20 days, on average)

This trial's timeline: 3 weeks for screening, Varies for treatment, and during hospital stay (up to 20 days, on average) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Time to First Antibiotic Administration in the ED

Secondary outcome measures

Antibiotic Days of Therapy

EMS Documentation of Sepsis

Septicemia

+6 more

IMPRESS Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: PRESS InterventionExperimental Treatment1 Intervention

Study sites will participate in the intervention phase for 6 to 18 months, depending on the order of cluster randomization. Sites will switch from the baseline phase in approximately 6 month blocks, with all sites delivering the intervention for the final 6 months of the study.

Group II: Standard of CareActive Control1 Intervention

Study sites will participate in the standard of care phase to collect baseline data for 6 to 18 months, depending on the order of cluster randomization. All sites are in the baseline phase for the first 6 months then sites will switch one at a time, every 6 months, to the intervention phase of the study.

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Centers for Disease Control and PreventionFED

875 Previous Clinical Trials

22,476,402 Total Patients Enrolled

6 Trials studying Sepsis

62,293 Patients Enrolled for Sepsis

Emory UniversityLead Sponsor

1,638 Previous Clinical Trials

2,559,532 Total Patients Enrolled

13 Trials studying Sepsis

10,247 Patients Enrolled for Sepsis

Carmen C Polito, MD, MScPrincipal InvestigatorEmory University

Media Library

PRESS Intervention Clinical Trial Eligibility Overview. Trial Name: NCT05502107 — N/A

Sepsis Research Study Groups: PRESS Intervention, Standard of Care

Sepsis Clinical Trial 2023: PRESS Intervention Highlights & Side Effects. Trial Name: NCT05502107 — N/A

PRESS Intervention 2023 Treatment Timeline for Medical Study. Trial Name: NCT05502107 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does this research program accept new participants?

"The clinicaltrials.gov website indicates that this trial, which was posted on December 1st 2022 and last updated October 11th 2022, is not currently recruiting participants. Despite this, 169 other studies are actively looking for volunteers to take part in their research endeavors."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Impact of a Prehospital Sepsis Protocol on Timely Antibiotic Administration and Subsequent Adverse Events

Carmen Polito 2023. "Impact of a Prehospital Sepsis Protocol on Timely Antibiotic Administration and Subsequent Adverse Events". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05502107.

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