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Prehospital Sepsis Protocol for Sepsis (IMPRESS Trial)

Led By Carmen C Polito, MD, MSc
Research Sponsored by Emory University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Screening 3 weeks
Treatment Varies
Follow Up during hospital stay (up to 20 days, on average)
Awards & highlights

IMPRESS Trial Summary

This trial will test if an emergency medical services (EMS) based sepsis screening and early warning protocol can improve the timing of sepsis care in the emergency department (ED).

Who is the study for?
This trial is for adults who have signs of sepsis, like a fast pulse rate over 90 bpm, low blood pressure under 110 mmHg, or rapid breathing over 20 breaths per minute. They must be transported by EMS to a participating hospital and meet other criteria such as being aged 40+, having a high temperature or low oxygen levels. Pregnant individuals and those with trauma, cardiac arrest, psychiatric emergencies or toxic ingestion are excluded.Check my eligibility
What is being tested?
The study tests the 'PRESS Intervention', which is an early warning protocol used by emergency services to identify and start treatment for sepsis before reaching the hospital. The goal is to see if this prehospital procedure can speed up care once patients arrive at the Emergency Department.See study design
What are the potential side effects?
Since this trial focuses on improving response times rather than testing new medications, it does not directly involve side effects from interventions. However, there may be risks associated with delayed or accelerated medical procedures.

IMPRESS Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~during hospital stay (up to 20 days, on average)
This trial's timeline: 3 weeks for screening, Varies for treatment, and during hospital stay (up to 20 days, on average) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Time to First Antibiotic Administration in the ED
Secondary outcome measures
Antibiotic Days of Therapy
EMS Documentation of Sepsis
+6 more

IMPRESS Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: PRESS InterventionExperimental Treatment1 Intervention
Study sites will participate in the intervention phase for 6 to 18 months, depending on the order of cluster randomization. Sites will switch from the baseline phase in approximately 6 month blocks, with all sites delivering the intervention for the final 6 months of the study.
Group II: Standard of CareActive Control1 Intervention
Study sites will participate in the standard of care phase to collect baseline data for 6 to 18 months, depending on the order of cluster randomization. All sites are in the baseline phase for the first 6 months then sites will switch one at a time, every 6 months, to the intervention phase of the study.

Find a Location

Who is running the clinical trial?

Centers for Disease Control and PreventionFED
875 Previous Clinical Trials
22,476,402 Total Patients Enrolled
6 Trials studying Sepsis
62,293 Patients Enrolled for Sepsis
Emory UniversityLead Sponsor
1,636 Previous Clinical Trials
2,559,573 Total Patients Enrolled
13 Trials studying Sepsis
10,247 Patients Enrolled for Sepsis
Carmen C Polito, MD, MScPrincipal InvestigatorEmory University

Media Library

PRESS Intervention Clinical Trial Eligibility Overview. Trial Name: NCT05502107 — N/A
Sepsis Research Study Groups: PRESS Intervention, Standard of Care
Sepsis Clinical Trial 2023: PRESS Intervention Highlights & Side Effects. Trial Name: NCT05502107 — N/A
PRESS Intervention 2023 Treatment Timeline for Medical Study. Trial Name: NCT05502107 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does this research program accept new participants?

"The clinicaltrials.gov website indicates that this trial, which was posted on December 1st 2022 and last updated October 11th 2022, is not currently recruiting participants. Despite this, 169 other studies are actively looking for volunteers to take part in their research endeavors."

Answered by AI
~412 spots leftby Dec 2024