Prehospital Sepsis Protocol for Sepsis
(IMPRESS Trial)
Trial Summary
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications.
What data supports the effectiveness of the PRESS Intervention treatment for sepsis?
The PRESS Intervention treatment aims to improve early recognition of sepsis by emergency medical services (EMS), which is crucial for better outcomes. Studies show that using specific protocols and screening tools in prehospital settings can enhance the identification of sepsis, potentially leading to timely and effective treatment.12345
Is the PRESS Intervention for sepsis safe for humans?
How does the Prehospital Sepsis Protocol treatment differ from other sepsis treatments?
The Prehospital Sepsis Protocol is unique because it focuses on early recognition and management of sepsis by emergency medical services (EMS) before reaching the hospital. It involves a screening tool that uses specific criteria and measurements, like end-tidal carbon dioxide, to identify sepsis early, which is different from traditional hospital-based treatments that start after diagnosis.13101112
What is the purpose of this trial?
The primary purpose of this study is to evaluate the impact of an Emergency Medical Services (EMS) based sepsis screening and early warning protocol on the timing of early sepsis care in the Emergency Department (ED).
Research Team
Carmen C Polito, MD, MSc
Principal Investigator
Emory University
Jonathan E Sevransky, MD, MHS
Principal Investigator
Emory University
Eligibility Criteria
This trial is for adults who have signs of sepsis, like a fast pulse rate over 90 bpm, low blood pressure under 110 mmHg, or rapid breathing over 20 breaths per minute. They must be transported by EMS to a participating hospital and meet other criteria such as being aged 40+, having a high temperature or low oxygen levels. Pregnant individuals and those with trauma, cardiac arrest, psychiatric emergencies or toxic ingestion are excluded.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Baseline Phase
Study sites participate in the standard of care phase to collect baseline data
Intervention Phase
Implementation of the PRESS protocol with sepsis screening and early warning protocol
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- PRESS Intervention
Find a Clinic Near You
Who Is Running the Clinical Trial?
Emory University
Lead Sponsor
Centers for Disease Control and Prevention
Collaborator