Zyclara

Molluscum Contagiosum, Condylomata Acuminata, Carcinoma, Basal Cell + 3 more

Treatment

8 FDA approvals

0 Active Studies for Zyclara

What is Zyclara

Imiquimod

The Generic name of this drug

Treatment Summary

Imiquimod is a medication used to treat genital and anal warts. It works by activating an immune response in the body which helps control the production of warts. Imiquimod does not actually treat the virus that causes warts, but it can help reduce their appearance. This medicine can also be used to treat actinic keratoses, a skin condition on the face and scalp, and certain types of skin cancer.

Aldara

is the brand name

Zyclara Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Aldara

Imiquimod

1997

27

Approved as Treatment by the FDA

Imiquimod, also known as Aldara, is approved by the FDA for 8 uses like Face and Actinic Keratoses of the scalp .

Face

Actinic Keratoses of the scalp

Actinic Keratoses of the face

Superficial Basal Cell Carcinoma

Condylomata Acuminata

Scalp structure

Carcinoma, Basal Cell

Condylomata Acuminata

Effectiveness

How Zyclara Affects Patients

Imiquimod is a medicine that helps to control the growth of warts on the skin of the genital and anal areas. This medication does not get rid of warts, and new warts may appear during treatment. It works by stimulating the body's own immune system to fight the virus that causes warts. Imiquimod is not used for warts inside the vagina, penis, or rectum. It can also be used to treat actinic keratoses, a skin condition of the face and scalp, and certain types of skin cancer called superficial basal cell carcinoma. This medicine is especially useful for treating areas of

How Zyclara works in the body

Imiquimod works by stimulating the body's immune system to fight disease. It does not directly target viruses, but it triggers the release of cytokines and interferons, which are molecules that help the body fight off infections. In treating basal cell carcinoma, it works by activating toll-like receptor-7, altering the immune response and causing diseased cells to die off. It also increases the movement of lymphocytes, dendritic cells, and macrophages into the tumor.

When to interrupt dosage

The quantity of Zyclara is contingent upon the identified disorder, including Communicable Diseases, Face and Superficial Basal Cell Carcinoma. The measure of dosage is contingent upon the approach of administration (e.g. Cream - Topical or Topical) as specified in the table below.

Condition

Dosage

Administration

Face

, 0.05 mg/mg, 0.125 mg/mg, 3.75 %, 5.0 %, 2.5 %, 0.0375 mg/mg, 0.0025 mg/mg, 0.025 mg/mg

, Topical, Cream - Topical, Cream, Cream - Cutaneous, Cutaneous, Gel - Topical, Gel

Condylomata Acuminata

, 0.05 mg/mg, 0.125 mg/mg, 3.75 %, 5.0 %, 2.5 %, 0.0375 mg/mg, 0.0025 mg/mg, 0.025 mg/mg

, Topical, Cream - Topical, Cream, Cream - Cutaneous, Cutaneous, Gel - Topical, Gel

Carcinoma, Basal Cell

, 0.05 mg/mg, 0.125 mg/mg, 3.75 %, 5.0 %, 2.5 %, 0.0375 mg/mg, 0.0025 mg/mg, 0.025 mg/mg

, Topical, Cream - Topical, Cream, Cream - Cutaneous, Cutaneous, Gel - Topical, Gel

Communicable Diseases

, 0.05 mg/mg, 0.125 mg/mg, 3.75 %, 5.0 %, 2.5 %, 0.0375 mg/mg, 0.0025 mg/mg, 0.025 mg/mg

, Topical, Cream - Topical, Cream, Cream - Cutaneous, Cutaneous, Gel - Topical, Gel

Molluscum Contagiosum

, 0.05 mg/mg, 0.125 mg/mg, 3.75 %, 5.0 %, 2.5 %, 0.0375 mg/mg, 0.0025 mg/mg, 0.025 mg/mg

, Topical, Cream - Topical, Cream, Cream - Cutaneous, Cutaneous, Gel - Topical, Gel

Scalp structure

, 0.05 mg/mg, 0.125 mg/mg, 3.75 %, 5.0 %, 2.5 %, 0.0375 mg/mg, 0.0025 mg/mg, 0.025 mg/mg

, Topical, Cream - Topical, Cream, Cream - Cutaneous, Cutaneous, Gel - Topical, Gel

Warnings

Zyclara has a single contraindication, thus it should not be employed when afflicted with any of the conditions outlined in the below table.

Zyclara Contraindications

Condition

Risk Level

Notes

Pulse Frequency

Do Not Combine

There are 6 known major drug interactions with Zyclara.

Common Zyclara Drug Interactions

Drug Name

Risk Level

Description

Allogeneic processed thymus tissue

Minor

The therapeutic efficacy of Allogeneic processed thymus tissue can be decreased when used in combination with Imiquimod.

Inebilizumab

Minor

The risk or severity of infection can be increased when Imiquimod is combined with Inebilizumab.

Vibrio cholerae CVD 103-HgR strain live antigen

Minor

The therapeutic efficacy of Vibrio cholerae CVD 103-HgR strain live antigen can be decreased when used in combination with Imiquimod.

Haloperidol

Moderate

The serum concentration of Haloperidol can be increased when it is combined with Imiquimod.

Magnesium

Moderate

The serum concentration of Magnesium can be decreased when it is combined with Imiquimod.

Zyclara Toxicity & Overdose Risk

Overdosing on ibuprofen can cause flu-like symptoms like fever, exhaustion, headache, nausea, diarrhea, and muscle pain.

image of a doctor in a lab doing drug, clinical research

Zyclara Novel Uses: Which Conditions Have a Clinical Trial Featuring Zyclara?

Nine active studies are presently evaluating the potential of Zyclara to ameliorate Molluscum Contagiosum, Facial and Condylomata Acuminata.

Condition

Clinical Trials

Trial Phases

Condylomata Acuminata

0 Actively Recruiting

Carcinoma, Basal Cell

0 Actively Recruiting

Scalp structure

0 Actively Recruiting

Molluscum Contagiosum

1 Actively Recruiting

Phase 3

Communicable Diseases

0 Actively Recruiting

Face

0 Actively Recruiting

Zyclara Reviews: What are patients saying about Zyclara?

5

Patient Review

2/24/2016

Zyclara for Roughened Red Patches of Skin due to Sun Exposure

Though it's not fun to use, this medication is very effective at getting rid of actinic keratosis. It gets rid of the surface AK, but if you've been exposed to the sun for a long time like I have, the AK places are more than one layer deep.

4.7

Patient Review

8/20/2015

Zyclara for Superficial Basal Cell Carcinoma of the Skin

I just completed the 6-week course (2 weeks on, 2 weeks off, 2 weeks on). I'm not sure yet if it's been effective, but I did experience some side effects like fever blisters, skin break down, fatigue, lightheadedness and nausea. The second round of treatment produced greater side effects than the first two weeks.

4.3

Patient Review

1/30/2015

Zyclara for Superficial Basal Cell Carcinoma of the Skin

In the past, I've found this medication to be effective in reducing the redness and swelling of actinic keratoses. However, I'm still dealing with a large "Christmas light" on my face after completing the treatment regimen. I'm not sure if this is normal or if I have a bigger problem.

4

Patient Review

8/22/2014

Zyclara for Roughened Red Patches of Skin due to Sun Exposure

I applied the creme for 14 days as directed but saw no changes whatsoever.

4

Patient Review

6/20/2015

Zyclara for Roughened Red Patches of Skin due to Sun Exposure

I developed several fever blisters after using this treatment for two weeks as directed. I'm not sure if it's worth it.

4

Patient Review

6/11/2016

Zyclara for Superficial Basal Cell Carcinoma of the Skin

I'm on day 8 of the treatment. I was advised by my doctor to use it for two weeks, then take a break for two weeks, and then start up again for another two weeks. So far, I haven't seen the great results that I was hoping for. My face is red and sore, with lots of scabs forming. It's also itchy, hot, and tender. Additionally, I've been feeling tired and achy all over my body.

3.7

Patient Review

9/3/2014

Zyclara for Roughened Red Patches of Skin due to Sun Exposure

I'm on day 13 of using Zyclara and my face looks terrible. I have fever blisters all over my mouth, which is incredibly painful. I don't know if I can make it through another day but the treatment is very effective.

3.7

Patient Review

9/1/2015

Zyclara for Roughened Red Patches of Skin due to Sun Exposure

I used Zyclara a few months ago to target red and dry areas of my scalp. The results were good with few side effects. I have now been instructed by my dermatologist, at Mt. Sinai, NYC, to cover my entire scalp, forehead and sides of my face. I am on day 6 and many areas are reacting to the medication. I have muscle aches in my arms and lower back. Pretty high fever, which I started treating with Acetaminophen with good results.

3.3

Patient Review

9/16/2020

Zyclara for Superficial Basal Cell Carcinoma of the Skin

Although it was effective, this treatment left my face with some permanent scarring. It was also quite painful to use, and made my skin look like it had been burned.

3

Patient Review

2/15/2018

Zyclara for Roughened Red Patches of Skin due to Sun Exposure

I unfortunately experienced some hearing loss and an increase in tinnitus while taking this medication.

2.3

Patient Review

7/21/2014

Zyclara for Roughened Red Patches of Skin due to Sun Exposure

1.3

Patient Review

2/9/2015

Zyclara for Superficial Basal Cell Carcinoma of the Skin

I'm a 41 year old woman who's had two surgeries on my face. My dermatologist suggested this treatment, and though I was worried about looking worse before getting better, I decided to give it a try. I'm glad I did! Sure, there were some side effects like headaches and feeling chilly, but anything that can help me avoid surgery is worth it in my book.

Patient Q&A Section about zyclara

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How much does Zyclara cost?

"The price of Zyclara topical cream 3.75% varies depending on the pharmacy, but is typically around $1,307 for a supply of 7.5 grams. This price is for cash paying customers only and does not include insurance plans."

Answered by AI

How long does it take for Zyclara to work?

"The effects of Zyclara can take 5-7 days to start appearing, and usually stop around day 10. However, stopping the medication can result in the intensification of symptoms for several days afterwards, as it is difficult to immediately stop the medication's effects. Zyclara can also cause flu-like symptoms because it stimulates an immune response."

Answered by AI

How long do you use Zyclara?

"Adults and children 12 years of age and older can use Zyclara® by applying a thin film to the wart once a day at bedtime. The maximum amount of time it can be used is 8 weeks or until the wart is gone. Children younger than 12 years of age need a doctor to determine the amount they should use."

Answered by AI

What is Zyclara cream used for?

"Zyclara is a cream that is used to treat actinic keratoses and external genital or perianal warts. It comes in two strengths, 2.5% or 3.75%. Zyclara Cream works by stimulating the immune system to fight the infections. It is for people 12 years of age and older."

Answered by AI