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What is Zyclara
ImiquimodThe Generic name of this drug
Treatment SummaryImiquimod is a medication used to treat genital and anal warts. It works by activating an immune response in the body which helps control the production of warts. Imiquimod does not actually treat the virus that causes warts, but it can help reduce their appearance. This medicine can also be used to treat actinic keratoses, a skin condition on the face and scalp, and certain types of skin cancer.
Aldarais the brand name
Zyclara Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Aldara
Imiquimod
1997
27
Approved as Treatment by the FDA
Imiquimod, also known as Aldara, is approved by the FDA for 4 uses like Superficial Basal Cell Carcinoma and Condylomata Acuminata .Superficial Basal Cell Carcinoma
Condylomata Acuminata
Face
Scalp structure
Effectiveness
How Zyclara Affects PatientsImiquimod is a medicine that helps to control the growth of warts on the skin of the genital and anal areas. This medication does not get rid of warts, and new warts may appear during treatment. It works by stimulating the body's own immune system to fight the virus that causes warts. Imiquimod is not used for warts inside the vagina, penis, or rectum. It can also be used to treat actinic keratoses, a skin condition of the face and scalp, and certain types of skin cancer called superficial basal cell carcinoma. This medicine is especially useful for treating areas of
How Zyclara works in the bodyImiquimod works by stimulating the body's immune system to fight disease. It does not directly target viruses, but it triggers the release of cytokines and interferons, which are molecules that help the body fight off infections. In treating basal cell carcinoma, it works by activating toll-like receptor-7, altering the immune response and causing diseased cells to die off. It also increases the movement of lymphocytes, dendritic cells, and macrophages into the tumor.
When to interrupt dosage
The quantity of Zyclara is contingent upon the identified disorder, including Communicable Diseases, Face and Superficial Basal Cell Carcinoma. The measure of dosage is contingent upon the approach of administration (e.g. Cream - Topical or Topical) as specified in the table below.Condition
Dosage
Administration
Face
, 0.05 mg/mg, 0.125 mg/mg, 3.75 %, 5.0 %, 2.5 %, 0.0375 mg/mg, 0.0025 mg/mg, 0.025 mg/mg
, Cream, Topical, Cream - Topical, Gel - Topical, Gel, Cutaneous, Cream - Cutaneous
Condylomata Acuminata
, 0.05 mg/mg, 0.125 mg/mg, 3.75 %, 5.0 %, 2.5 %, 0.0375 mg/mg, 0.0025 mg/mg, 0.025 mg/mg
, Cream, Topical, Cream - Topical, Gel - Topical, Gel, Cutaneous, Cream - Cutaneous
Molluscum Contagiosum
, 0.05 mg/mg, 0.125 mg/mg, 3.75 %, 5.0 %, 2.5 %, 0.0375 mg/mg, 0.0025 mg/mg, 0.025 mg/mg
, Cream, Topical, Cream - Topical, Gel - Topical, Gel, Cutaneous, Cream - Cutaneous
Communicable Diseases
, 0.05 mg/mg, 0.125 mg/mg, 3.75 %, 5.0 %, 2.5 %, 0.0375 mg/mg, 0.0025 mg/mg, 0.025 mg/mg
, Cream, Topical, Cream - Topical, Gel - Topical, Gel, Cutaneous, Cream - Cutaneous
Scalp structure
, 0.05 mg/mg, 0.125 mg/mg, 3.75 %, 5.0 %, 2.5 %, 0.0375 mg/mg, 0.0025 mg/mg, 0.025 mg/mg
, Cream, Topical, Cream - Topical, Gel - Topical, Gel, Cutaneous, Cream - Cutaneous
Superficial Basal Cell Carcinoma
, 0.05 mg/mg, 0.125 mg/mg, 3.75 %, 5.0 %, 2.5 %, 0.0375 mg/mg, 0.0025 mg/mg, 0.025 mg/mg
, Cream, Topical, Cream - Topical, Gel - Topical, Gel, Cutaneous, Cream - Cutaneous
Warnings
Zyclara has a single contraindication, thus it should not be employed when afflicted with any of the conditions outlined in the below table.Zyclara ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Common Zyclara Drug Interactions
Drug Name
Risk Level
Description
Allogeneic processed thymus tissue
Minor
The therapeutic efficacy of Allogeneic processed thymus tissue can be decreased when used in combination with Imiquimod.
Inebilizumab
Minor
The risk or severity of infection can be increased when Imiquimod is combined with Inebilizumab.
Vibrio cholerae CVD 103-HgR strain live antigen
Minor
The therapeutic efficacy of Vibrio cholerae CVD 103-HgR strain live antigen can be decreased when used in combination with Imiquimod.
Haloperidol
Moderate
The serum concentration of Haloperidol can be increased when it is combined with Imiquimod.
Magnesium
Moderate
The serum concentration of Magnesium can be decreased when it is combined with Imiquimod.
Zyclara Toxicity & Overdose RiskOverdosing on ibuprofen can cause flu-like symptoms like fever, exhaustion, headache, nausea, diarrhea, and muscle pain.
Zyclara Novel Uses: Which Conditions Have a Clinical Trial Featuring Zyclara?
Nine active studies are presently evaluating the potential of Zyclara to ameliorate Molluscum Contagiosum, Facial and Condylomata Acuminata.Condition
Clinical Trials
Trial Phases
Scalp structure
0 Actively Recruiting
Molluscum Contagiosum
2 Actively Recruiting
Not Applicable, Phase 3
Face
0 Actively Recruiting
Condylomata Acuminata
1 Actively Recruiting
Phase 1, Phase 2
Superficial Basal Cell Carcinoma
4 Actively Recruiting
Phase 3, Phase 2, Not Applicable
Communicable Diseases
1 Actively Recruiting
Phase 3
Zyclara Reviews: What are patients saying about Zyclara?
5Patient Review
2/24/2016 Though it's not fun to use, this medication is very effective at getting rid of actinic keratosis. It gets rid of the surface AK, but if you've been exposed to the sun for a long time like I have, the AK places are more than one layer deep.
4.7Patient Review
8/20/2015 I just completed the 6-week course (2 weeks on, 2 weeks off, 2 weeks on). I'm not sure yet if it's been effective, but I did experience some side effects like fever blisters, skin break down, fatigue, lightheadedness and nausea. The second round of treatment produced greater side effects than the first two weeks.
4.3Patient Review
1/30/2015 In the past, I've found this medication to be effective in reducing the redness and swelling of actinic keratoses. However, I'm still dealing with a large "Christmas light" on my face after completing the treatment regimen. I'm not sure if this is normal or if I have a bigger problem.
4Patient Review
8/22/2014 I applied the creme for 14 days as directed but saw no changes whatsoever.
4Patient Review
6/20/2015 I developed several fever blisters after using this treatment for two weeks as directed. I'm not sure if it's worth it.
4Patient Review
6/11/2016 I'm on day 8 of the treatment. I was advised by my doctor to use it for two weeks, then take a break for two weeks, and then start up again for another two weeks. So far, I haven't seen the great results that I was hoping for. My face is red and sore, with lots of scabs forming. It's also itchy, hot, and tender. Additionally, I've been feeling tired and achy all over my body.
3.7Patient Review
9/3/2014 I'm on day 13 of using Zyclara and my face looks terrible. I have fever blisters all over my mouth, which is incredibly painful. I don't know if I can make it through another day but the treatment is very effective.
3.7Patient Review
9/1/2015 I used Zyclara a few months ago to target red and dry areas of my scalp. The results were good with few side effects. I have now been instructed by my dermatologist, at Mt. Sinai, NYC, to cover my entire scalp, forehead and sides of my face. I am on day 6 and many areas are reacting to the medication. I have muscle aches in my arms and lower back. Pretty high fever, which I started treating with Acetaminophen with good results.
3.3Patient Review
9/16/2020 Although it was effective, this treatment left my face with some permanent scarring. It was also quite painful to use, and made my skin look like it had been burned.
3Patient Review
2/15/2018 I unfortunately experienced some hearing loss and an increase in tinnitus while taking this medication.
2.3Patient Review
7/21/20141.3Patient Review
2/9/2015 I'm a 41 year old woman who's had two surgeries on my face. My dermatologist suggested this treatment, and though I was worried about looking worse before getting better, I decided to give it a try. I'm glad I did! Sure, there were some side effects like headaches and feeling chilly, but anything that can help me avoid surgery is worth it in my book.
Patient Q&A Section about zyclara
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.How much does Zyclara cost?
"The price of Zyclara topical cream 3.75% varies depending on the pharmacy, but is typically around $1,307 for a supply of 7.5 grams. This price is for cash paying customers only and does not include insurance plans."
Answered by AI
How long does it take for Zyclara to work?
"The effects of Zyclara can take 5-7 days to start appearing, and usually stop around day 10. However, stopping the medication can result in the intensification of symptoms for several days afterwards, as it is difficult to immediately stop the medication's effects. Zyclara can also cause flu-like symptoms because it stimulates an immune response."
Answered by AI
How long do you use Zyclara?
"Adults and children 12 years of age and older can use Zyclara® by applying a thin film to the wart once a day at bedtime. The maximum amount of time it can be used is 8 weeks or until the wart is gone. Children younger than 12 years of age need a doctor to determine the amount they should use."
Answered by AI
What is Zyclara cream used for?
"Zyclara is a cream that is used to treat actinic keratoses and external genital or perianal warts. It comes in two strengths, 2.5% or 3.75%. Zyclara Cream works by stimulating the immune system to fight the infections. It is for people 12 years of age and older."
Answered by AI